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Insomnia

insomnia, insomnia cookies
Insomnia, also known as sleeplessness, is a sleep disorder where people have trouble sleeping1 They may have difficulty falling asleep, or staying asleep as long as desired97 Insomnia is typically followed by daytime sleepiness, low energy, irritability, and a depressed mood It may result in an increased risk of motor vehicle collisions, as well as problems focusing and learning Insomnia can be short term, lasting for days or weeks, or long term, lasting more than a month1

Insomnia can occur independently or as a result of another problem2 Conditions that can result in insomnia include psychological stress, chronic pain, heart failure, hyperthyroidism, heartburn, restless leg syndrome, menopause, certain medications, and drugs such as caffeine, nicotine, and alcohol23 Other risk factors include working night shifts and sleep apnea7 Diagnosis is based on sleep habits and an examination to look for underlying causes A sleep study may be done to look for underlying sleep disorders10 Screening may be done with two questions: "do you experience difficulty sleeping" and "do you have difficulty falling or staying asleep"7

Sleep hygiene and lifestyle changes are typically the first treatment for insomnia64 Sleep hygiene includes a consistent bedtime, exposure to sunlight, a quiet and dark room, and regular exercise6 Cognitive behavioral therapy may be added to this511 While sleeping pills may help, they are associated with injuries, dementia, and addiction45 Medications are not recommended for more than four or five weeks5 The effectiveness and safety of alternative medicine is unclear45

Between 10% and 30% of adults have insomnia at any given point in time and up to half of people have insomnia in a given year738 About 6% of people have insomnia that is not due to another problem and lasts for more than a month7 People over the age of 65 are affected more often than younger people6 Females are more often affected than males3 Descriptions of insomnia occur at least as far back as ancient Greece12

Contents

  • 1 Classification
    • 11 DSM-5 criteria
    • 12 Types
    • 13 Patterns
    • 14 Poor sleep quality
    • 15 Subjectivity
  • 2 Causes
    • 21 Substance-induced
      • 211 Alcohol-induced
      • 212 Benzodiazepine-induced
      • 213 Opioid-induced
    • 22 Risk factors
  • 3 Mechanism
  • 4 Diagnosis
  • 5 Prevention
  • 6 Treatment
    • 61 Non-medication based
      • 611 Sleep hygiene
      • 612 Cognitive behavioral therapy
      • 613 Internet interventions
    • 62 Medications
      • 621 Antihistamines
      • 622 Melatonin
      • 623 Antidepressants
      • 624 Benzodiazepines
      • 625 Benzodiazepine-like medications
      • 626 Antipsychotics
    • 63 Alternative medicine
  • 7 Prognosis
  • 8 Epidemiology
  • 9 Society and culture
  • 10 References
  • 11 External links

Classificationedit

DSM-5 criteriaedit

The DSM-5 criteria for insomnia include the following:13

Predominant complaint of dissatisfaction with sleep quantity or quality, associated with one or more of the following symptoms:

  • Difficulty initiating sleep In children, this may manifest as difficulty initiating sleep without caregiver intervention
  • Difficulty maintaining sleep, characterized by frequent awakenings or problems returning to sleep after awakenings In children, this may manifest as difficulty returning to sleep without caregiver intervention
  • Early-morning awakening with inability to return to sleep

In addition,

  • The sleep disturbance causes clinically significant distress or impairment in social, occupational, educational, academic, behavioral, or other important areas of functioning
  • The sleep difficulty occurs at least 3 nights per week
  • The sleep difficulty is present for at least 3 months
  • The sleep difficulty occurs despite adequate opportunity for sleep
  • The insomnia is not better explained by and does not occur exclusively during the course of another sleep-wake disorder eg, narcolepsy, a breathing-related sleep disorder, a circadian rhythm sleep-wake disorder, a parasomnia
  • The insomnia is not attributable to the physiological effects of a substance eg, a drug of abuse, a medication
  • Coexisting mental disorders and medical conditions do not adequately explain the predominant complaint of insomnia

Typesedit

Insomnia can be classified as transient, acute, or chronic

  1. Transient insomnia lasts for less than a week It can be caused by another disorder, by changes in the sleep environment, by the timing of sleep, severe depression, or by stress Its consequences – sleepiness and impaired psychomotor performance – are similar to those of sleep deprivation14
  2. Acute insomnia is the inability to consistently sleep well for a period of less than a month Insomnia is present when there is difficulty initiating or maintaining sleep or when the sleep that is obtained is non-refreshing or of poor quality These problems occur despite adequate opportunity and circumstances for sleep and they must result in problems with daytime function15 Acute insomnia is also known as short term insomnia or stress related insomnia16
  3. Chronic insomnia lasts for longer than a month It can be caused by another disorder, or it can be a primary disorder People with high levels of stress hormones or shifts in the levels of cytokines are more likely than others to have chronic insomnia17 Its effects can vary according to its causes They might include muscular weariness, hallucinations, and/or mental fatigue Chronic insomnia can cause double vision14

Patternsedit

Symptoms of insomnia:18

  • difficulty falling asleep, including difficulty finding a comfortable sleeping position
  • waking during the night and being unable to return to sleep
  • feeling unrefreshed upon waking
  • daytime sleepiness, irritability or anxiety

Sleep-onset insomnia is difficulty falling asleep at the beginning of the night, often a symptom of anxiety disorders Delayed sleep phase disorder can be misdiagnosed as insomnia, as sleep onset is delayed to much later than normal while awakening spills over into daylight hours19

It is common for patients who have difficulty falling asleep to also have nocturnal awakenings with difficulty returning to sleep Two-thirds of these patients wake up in the middle of the night, with more than half having trouble falling back to sleep after a middle-of-the-night awakening20

Early morning awakening is an awakening occurring earlier more than 30 minutes than desired with an inability to go back to sleep, and before total sleep time reaches 65 hours Early morning awakening is often a characteristic of depression21

Poor sleep qualityedit

Poor sleep quality can occur as a result of, for example, restless legs, sleep apnea or major depression Poor sleep quality is caused by the individual not reaching stage 3 or delta sleep which has restorative properties22

Major depression leads to alterations in the function of the hypothalamic-pituitary-adrenal axis, causing excessive release of cortisol which can lead to poor sleep quality

Nocturnal polyuria, excessive nighttime urination, can be very disturbing to sleep23

Subjectivityedit

Main article: Sleep state misperception

Some cases of insomnia are not really insomnia in the traditional sense People experiencing sleep state misperception often sleep for normal durations, yet overestimate the time taken to fall and remain asleep24

Causesedit

Potential complications of insomnia25

Symptoms of insomnia can be caused by or be associated with:

  • Use of psychoactive drugs such as stimulants, including certain medications, herbs, caffeine, nicotine, cocaine, amphetamines, methylphenidate, aripiprazole, MDMA, modafinil, or excessive alcohol intake26
  • Use of or withdrawal from alcohol and other sedatives, such as anti-anxiety and sleep drugs like benzodiazepines26
  • Use of or withdrawal from pain-relievers such as opioids26
  • Previous thoracic surgery
  • Heart disease27
  • Deviated nasal septum and nocturnal breathing disorders28
  • Restless legs syndrome, which can cause sleep onset insomnia due to the discomforting sensations felt and the need to move the legs or other body parts to relieve these sensations29
  • Periodic limb movement disorder PLMD, which occurs during sleep and can cause arousals of which the sleeper is unaware30
  • Pain,31 an injury or condition that causes pain can preclude an individual from finding a comfortable position in which to fall asleep, and can in addition cause awakening
  • Hormone shifts such as those that precede menstruation and those during menopause32
  • Life events such as fear, stress, anxiety, emotional or mental tension, work problems, financial stress, birth of a child and bereavement29
  • Gastrointestinal issues such as heartburn or constipation33
  • Mental disorders such as bipolar disorder, clinical depression, generalized anxiety disorder, post traumatic stress disorder, schizophrenia, obsessive compulsive disorder, dementia,34 and ADHD35
  • Disturbances of the circadian rhythm, such as shift work and jet lag, can cause an inability to sleep at some times of the day and excessive sleepiness at other times of the day Chronic circadian rhythm disorders are characterized by similar symptoms26
  • Certain neurological disorders, brain lesions, or a history of traumatic brain injury36
  • Medical conditions such as hyperthyroidism and rheumatoid arthritis37
  • Abuse of over-the counter or prescription sleep aids sedative or depressant drugs can produce rebound insomnia26
  • Poor sleep hygiene, eg, noise or over-consumption of caffeine26
  • A rare genetic condition can cause a prion-based, permanent and eventually fatal form of insomnia called fatal familial insomnia38
  • Physical exercise Exercise-induced insomnia is common in athletes in the form of prolonged sleep onset latency39

Sleep studies using polysomnography have suggested that people who have sleep disruption have elevated nighttime levels of circulating cortisol and adrenocorticotropic hormone They also have an elevated metabolic rate, which does not occur in people who do not have insomnia but whose sleep is intentionally disrupted during a sleep study Studies of brain metabolism using positron emission tomography PET scans indicate that people with insomnia have higher metabolic rates by night and by day The question remains whether these changes are the causes or consequences of long-term insomnia37

Substance-inducededit

Alcohol-inducededit

Main article: Alcohol use and sleep

Alcohol is often used as a form of self-treatment of insomnia to induce sleep However, alcohol use to induce sleep can be a cause of insomnia Long-term use of alcohol is associated with a decrease in NREM stage 3 and 4 sleep as well as suppression of REM sleep and REM sleep fragmentation Frequent moving between sleep stages occurs, with awakenings due to headaches, the need to urinate, dehydration, and excessive sweating Glutamine rebound also plays a role as when someone is drinking; alcohol inhibits glutamine, one of the body's natural stimulants When the person stops drinking, the body tries to make up for lost time by producing more glutamine than it needs The increase in glutamine levels stimulates the brain while the drinker is trying to sleep, keeping him/her from reaching the deepest levels of sleep40 Stopping chronic alcohol use can also lead to severe insomnia with vivid dreams During withdrawal REM sleep is typically exaggerated as part of a rebound effect41

Benzodiazepine-inducededit

Like alcohol, benzodiazepines, such as alprazolam, clonazepam, lorazepam and diazepam, are commonly used to treat insomnia in the short-term both prescribed and self-medicated, but worsen sleep in the long-term While benzodiazepines can put people to sleep ie, inhibit NREM stage 1 and 2 sleep, while asleep, the drugs disrupt sleep architecture: decreasing sleep time, delaying time to REM sleep, and decreasing deep slow-wave sleep the most restorative part of sleep for both energy and mood424344

Opioid-inducededit

Opioid medications such as hydrocodone, oxycodone, and morphine are used for insomnia that is associated with pain due to their analgesic properties and hypnotic effects Opioids can fragment sleep and decrease REM and stage 2 sleep By producing analgesia and sedation, opioids may be appropriate in carefully selected patients with pain-associated insomnia31 However, dependence on opioids can lead to long-term sleep disturbances45

Risk factorsedit

Insomnia affects people of all age groups but people in the following groups have a higher chance of acquiring insomniacitation needed

  • Individuals older than 60
  • History of mental health disorder including depression, etc
  • Emotional stress
  • Working late night shifts
  • Traveling through different time zones9

Mechanismedit

Two main models exists as to the mechanism of insomnia, the cognitive and physiological The cognitive model suggests rumination and hyperarousal prevent sleep and lead to an episode of insomnia The physiological model is based upon three major findings in people with insomnia; firstly, increased urinary cortisol and catecholamines have been found suggesting increased activity of the HPA axis and arousal; second increased global cerebral glucose utilization during wakefulness and NREM sleep in people with insomnia; and lastly increased full body metabolism and heart rate in those with insomnia All these findings taken together suggest a dysregulation of the arousal system, cognitive system and HPA axis all contributing to insomnia4647 However, it is unknown if the hyperarousal is a result of, or cause of insomnia Altered levels of the inhibitory neurotransmitter GABA have been found, but the results have been inconsistent, and the implications of altered levels of such a ubiquitous neurotransmitter are unknown Studies on whether insomnia is driven by circadian control over sleep or a wake dependent process have shown inconsistent results, but some literature suggests a dysregulation of the circadian rhythm based on core temperature48 Increased beta activity and decreased delta wave activity has been observed on electroencephalograms; however, the implication of this is unknown49

Around half of post-menopausal women experience sleep disturbances, and generally sleep disturbance is about twice as common in women as men; this appears to be due in part, but not completely, to changes in hormone levels, especially in and post-menopause3250

Changes in sex hormones in both men and women as they age may account in part for increased prevalence of sleep disorders in older people51

Diagnosisedit

In medicine, insomnia is widely measured using the Athens insomnia scale52 It is measured using eight different parameters related to sleep, finally represented as an overall scale which assesses an individual's sleep pattern

A qualified sleep specialist should be consulted for the diagnosis of any sleep disorder so the appropriate measures can be taken Past medical history and a physical examination need to be done to eliminate other conditions that could be the cause of insomnia After all other conditions are ruled out a comprehensive sleep history should be taken The sleep history should include sleep habits, medications prescription and non-prescription, alcohol consumption, nicotine and caffeine intake, co-morbid illnesses, and sleep environment53 A sleep diary can be used to keep track of the individual's sleep patterns The diary should include time to bed, total sleep time, time to sleep onset, number of awakenings, use of medications, time of awakening and subjective feelings in the morning53 The sleep diary can be replaced or validated by the use of out-patient actigraphy for a week or more, using a non-invasive device that measures movement54

Workers who complain of insomnia should not routinely have polysomnography to screen for sleep disorders55 This test may be indicated for patients with symptoms in addition to insomnia, including sleep apnea, obesity, a thick neck diameter, or high-risk fullness of the flesh in the oropharynx55 Usually, the test is not needed to make a diagnosis, and insomnia especially for working people can often be treated by changing a job schedule to make time for sufficient sleep and by improving sleep hygiene55

Some patients may need to do an overnight sleep study to determine if insomnia is present Such a study will commonly involve assessment tools including a polysomnogram and the multiple sleep latency test Specialists in sleep medicine are qualified to diagnose disorders within the, according to the ICSD, 81 major sleep disorder diagnostic categories56 Patients with some disorders, including delayed sleep phase disorder, are often mis-diagnosed with primary insomnia; when a person has trouble getting to sleep and awakening at desired times, but has a normal sleep pattern once asleep, a circadian rhythm disorder is a likely cause

In many cases, insomnia is co-morbid with another disease, side-effects from medications, or a psychological problem Approximately half of all diagnosed insomnia is related to psychiatric disorders57 In depression in many cases "insomnia should be regarded as a co-morbid condition, rather than as a secondary one;" insomnia typically predates psychiatric symptoms57 "In fact, it is possible that insomnia represents a significant risk for the development of a subsequent psychiatric disorder"7 Insomnia occur in between 60% and 80% of people with depression58 This may partly be due to treatment used for depression58

Determination of causation is not necessary for a diagnosis57

Preventionedit

Going to sleep and waking up at the same time every day can create a steady pattern which may help to prevent or treat insomnia9 Avoidance of vigorous exercise and any caffeinated drinks a few hours before going to sleep is recommended, while exercise earlier in the day is beneficial The bedroom should be cool and dark, and the bed should only be used for sleep and sex These are some of the points included in what doctors call "sleep hygiene"

Treatmentedit

It is important to identify or rule out medical and psychological causes before deciding on the treatment for insomnia59 Cognitive behavioral therapy CBT has been found to be as effective as medications for the short-term treatment of chronic insomnia The beneficial effects, in contrast to those produced by medications, may last well beyond the stopping of therapy60 Medications have been used mainly to reduce symptoms in insomnia of short duration; their role in the management of chronic insomnia remains unclear3 Several different types of medications are also effective for treating insomnia However, many doctors do not recommend relying on prescription sleeping pills for long-term use It is also important to identify and treat other medical conditions that may be contributing to insomnia, such as depression, breathing problems, and chronic pain61

Non-medication basededit

Non-medication based strategies have comparable efficacy to hypnotic medication for insomnia and they may have longer lasting effects Hypnotic medication is only recommended for short-term use because dependence with rebound withdrawal effects upon discontinuation or tolerance can develop62

Non medication based strategies provide long lasting improvements to insomnia and are recommended as a first line and long-term strategy of management The strategies include attention to sleep hygiene, stimulus control, behavioral interventions, sleep-restriction therapy, paradoxical intention, patient education and relaxation therapy63 Some examples are keeping a journal, restricting the time spent awake in bed, practicing relaxation techniques, and maintaining a regular sleep schedule and a wake-up time61 Behavioral therapy can assist a patient in developing new sleep behaviors to improve sleep quality and consolidation Behavioral therapy may include, learning healthy sleep habits to promote sleep relaxation, undergoing light therapy to help with worry-reduction strategies and regulating the circadian clock61

Music may improve insomnia in adults64 EEG biofeedback has demonstrated effectiveness in the treatment of insomnia with improvements in duration as well as quality of sleep65 Self-help therapy defined as a psychological therapy that can be worked through on one's own may improve sleep quality for adults with insomnia to a small or moderate degree66

Stimulus control therapy is a treatment for patients who have conditioned themselves to associate the bed, or sleep in general, with a negative response As stimulus control therapy involves taking steps to control the sleep environment, it is sometimes referred interchangeably with the concept of sleep hygiene Examples of such environmental modifications include using the bed for sleep or sex only, not for activities such as reading or watching television; waking up at the same time every morning, including on weekends; going to bed only when sleepy and when there is a high likelihood that sleep will occur; leaving the bed and beginning an activity in another location if sleep does not result in a reasonably brief period of time after getting into bed commonly ~20 min; reducing the subjective effort and energy expended trying to fall asleep; avoiding exposure to bright light during nighttime hours, and eliminating daytime naps67

A component of stimulus control therapy is sleep restriction, a technique that aims to match the time spent in bed with actual time spent asleep This technique involves maintaining a strict sleep-wake schedule, sleeping only at certain times of the day and for specific amounts of time to induce mild sleep deprivation Complete treatment usually lasts up to 3 weeks and involves making oneself sleep for only a minimum amount of time that they are actually capable of on average, and then, if capable ie when sleep efficiency improves, slowly increasing this amount ~15 min by going to bed earlier as the body attempts to reset its internal sleep clock Bright light therapy, which is often used to help early morning wakers reset their natural sleep cycle, can also be used with sleep restriction therapy to reinforce a new wake schedule Although applying this technique with consistency is difficult, it can have a positive effect on insomnia in motivated patients

Paradoxical intention is a cognitive reframing technique where the insomniac, instead of attempting to fall asleep at night, makes every effort to stay awake ie essentially stops trying to fall asleep One theory that may explain the effectiveness of this method is that by not voluntarily making oneself go to sleep, it relieves the performance anxiety that arises from the need or requirement to fall asleep, which is meant to be a passive act This technique has been shown to reduce sleep effort and performance anxiety and also lower subjective assessment of sleep-onset latency and overestimation of the sleep deficit a quality found in many insomniacs68

Sleep hygieneedit

Sleep hygiene is a common term for all of the behaviors which relate to the promotion of good sleep These behaviors are used as the basis of sleep interventions and are the primary focus of sleep education programs69 Behaviors include the use of caffeine, nicotine, and alcohol consumption, maximizing the regularity and efficiency of sleep episodes, minimizing medication usage and daytime napping, the promotion of regular exercise, and the facilitation of a positive sleep environment69 Exercise can be helpful when establishing a routine for sleep but should not be done close to the time that you are planning on going to sleep The creation of a positive sleep environment may also be helpful in reducing the symptoms of insomnia In order to create a positive sleep environment one should remove objects that can cause worry or distressful thoughts from viewcitation needed

Cognitive behavioral therapyedit

Main article: Cognitive behavioural therapy for insomnia

There is some evidence that cognitive behavioural therapy for insomnia is superior in the long-term to benzodiazepines and the nonbenzodiazepines in the treatment and management of insomnia70 In this therapy, patients are taught improved sleep habits and relieved of counter-productive assumptions about sleep Common misconceptions and expectations that can be modified include: 1 unrealistic sleep expectations eg, I need to have 8 hours of sleep each night, 2 misconceptions about insomnia causes eg, I have a chemical imbalance causing my insomnia, 3 amplifying the consequences of insomnia eg, I cannot do anything after a bad night's sleep, and 4 performance anxiety after trying for so long to have a good night's sleep by controlling the sleep process Numerous studies have reported positive outcomes of combining cognitive behavioral therapy for insomnia treatment with treatments such as stimulus control and the relaxation therapies Hypnotic medications are equally effective in the short-term treatment of insomnia but their effects wear off over time due to tolerance The effects of CBT-I have sustained and lasting effects on treating insomnia long after therapy has been discontinued7172 The addition of hypnotic medications with CBT-I adds no benefit in insomnia The long lasting benefits of a course of CBT-I shows superiority over pharmacological hypnotic drugs Even in the short term when compared to short-term hypnotic medication such as zolpidem Ambien, CBT-I still shows significant superiority Thus CBT-I is recommended as a first line treatment for insomnia73 Metacognition is also a recent trend in approach to behaviour therapy of insomnia74

Internet interventionsedit

Despite the therapeutic effectiveness and proven success of CBT, treatment availability is significantly limited by a lack of trained clinicians, poor geographical distribution of knowledgeable professionals, and expense75 One way to potentially overcome these barriers is to use the Internet to deliver treatment, making this effective intervention more accessible and less costly The Internet has already become a critical source of health-care and medical information76 Although the vast majority of health websites provide general information,7677 there is growing research literature on the development and evaluation of Internet interventions7879

These online programs are typically behaviorally-based treatments that have been operationalized and transformed for delivery via the Internet They are usually highly structured; automated or human supported; based on effective face-to-face treatment; personalized to the user; interactive; enhanced by graphics, animations, audio, and possibly video; and tailored to provide follow-up and feedback79

There is good evidence for the use computer based CBT for insomnia80

Medicationsedit

Many people with insomnia use sleeping tablets and other sedatives In some places medications are prescribed in over 95% of cases81 They; however, are a second line treatment82

The percentage of adults using a prescription sleep aid increases with age During 2005–2010, about 4% of US adults aged 20 and over reported that they took prescription sleep aids in the past 30 days Rates of use were lowest among the youngest age group those aged 20–39 at about 2%, increased to 6% among those aged 50–59, and reached 7% among those aged 80 and over More adult women 50% reported using prescription sleep aids than adult men 31% Non-Hispanic white adults reported higher use of sleep aids 47% than non-Hispanic black 25% and Mexican-American 20% adults No difference was shown between non-Hispanic black adults and Mexican-American adults in use of prescription sleep aids83

Antihistaminesedit

As an alternative to taking prescription drugs, some evidence shows that an average person seeking short-term help may find relief by taking over-the-counter antihistamines such as diphenhydramine or doxylamine84 Diphenhydramine and doxylamine are widely used in nonprescription sleep aids They are the most effective over-the-counter sedatives currently available, at least in much of Europe, and in Canada, Australia, and the United States, and are more sedating than some prescription hypnotics85 Antihistamine effectiveness for sleep may decrease over time, and anticholinergic side-effects such as dry mouth may also be a drawback with these particular drugs While addiction does not seem to be an issue with this class of drugs, they can induce dependence and rebound effects upon abrupt cessation of usecitation needed

Melatoninedit

The evidence for melatonin in treating insomnia is generally poor86 There is low quality evidence that it may speed the onset of sleep by 6 minutes86 Ramelteon, a melatonin receptor agonist, does not appear to speed the onset of sleep or the amount of sleep a person gets86

Most melatonin drugs have not been tested for longitudinal side effects87 Prolonged-release melatonin may improve quality of sleep in older people with minimal side effects8889

Studies have also shown that children who are on the Autism spectrum or have learning disabilities, Attention-Deficit Hyperactivity Disorder ADHD or related neurological diseases can benefit from the use of melatonin This is because they often have trouble sleeping due to their disorders For example, children with ADHD tend to have trouble falling asleep because of their hyperactivity and, as a result, tend to be tired during most of the day Another cause of insomnia in children with ADHD is the use of stimulants used to treat their disorder Children who have ADHD then, as well as the other disorders mentioned, may be given melatonin before bedtime in order to help them sleep90

Antidepressantsedit

Because insomnia is a common symptom of depression, antidepressants are effective for treating sleep problems whether or not they are associated with depression While all antidepressants help regulate sleep, some antidepressants such as amitriptyline, doxepin, mirtazapine, and trazodone can have an immediate sedative effect, and are prescribed to treat insomnia91 Amitriptyline and doxepin both have antihistaminergic, anticholinergic, and antiadrenergic properties, which contribute to both their therapeutic effects and side effect profiles, while mirtazapine's side effects are primarily antihistaminergic, and trazodone's side-effects are primarily antiadrenergic Mirtazapine is known to decrease sleep latency ie, the time it takes to fall asleep, promoting sleep efficiency and increasing the total amount of sleeping time in people with both depression and insomnia9293

Agomelatine, a melatonergic antidepressant with sleep-improving qualities that does not cause daytime drowsiness,94 is licensed for marketing in the European Union95 and TGA Australia96 After trials in the United States its development for use there was discontinued in October 201197 by Novartis, who had bought the rights to market it there from the European pharmaceutical company Servier98

Benzodiazepinesedit

Normison temazepam is a benzodiazepine commonly prescribed for insomnia and other sleep disorders99

The most commonly used class of hypnotics for insomnia are the benzodiazepines Benzodiazepines are not significantly better for insomnia than antidepressants100 Chronic users of hypnotic medications for insomnia do not have better sleep than chronic insomniacs not taking medications In fact, chronic users of hypnotic medications have more regular nighttime awakenings than insomniacs not taking hypnotic medications101 Many have concluded that these drugs cause an unjustifiable risk to the individual and to public health and lack evidence of long-term effectiveness It is preferred that hypnotics be prescribed for only a few days at the lowest effective dose and avoided altogether wherever possible, especially in the elderly102 Between 1993 and 2010, the prescribing of benzodiazepines to individuals with sleep disorders has decreased from 24% to 11% in the US, coinciding with the first release of nonbenzodiazepines103

The benzodiazepine and nonbenzodiazepine hypnotic medications also have a number of side-effects such as day time fatigue, motor vehicle crashes and other accidents, cognitive impairments and falls and fractures Elderly people are more sensitive to these side-effects104 Some benzodiazepines have demonstrated effectiveness in sleep maintenance in the short term but in the longer term benzodiazepines can lead to tolerance, physical dependence, benzodiazepine withdrawal syndrome upon discontinuation, and long-term worsening of sleep, especially after consistent usage over long periods of time Benzodiazepines, while inducing unconsciousness, actually worsen sleep as—like alcohol—they promote light sleep while decreasing time spent in deep sleep105 A further problem is, with regular use of short-acting sleep aids for insomnia, daytime rebound anxiety can emerge106 Although there is little evidence for benefit of benzodiazepines in insomnia compared to other treatments and evidence of major harm, prescriptions have continued to increase107 This is likely due to their addictive nature, both due to misuse and because—through their rapid action, tolerance and withdrawal—they can "trick" insomniacs into thinking they are helping with sleep There is a general awareness that long-term use of benzodiazepines for insomnia in most people is inappropriate and that a gradual withdrawal is usually beneficial due to the adverse effects associated with the long-term use of benzodiazepines and is recommended whenever possible108109

Benzodiazepines all bind unselectively to the GABAA receptor100 Some theorize that certain benzodiazepines hypnotic benzodiazepines have significantly higher activity at the α1 subunit of the GABAA receptor compared to other benzodiazepines for example, triazolam and temazepam have significantly higher activity at the α1 subunit compared to alprazolam and diazepam, making them superior sedative-hypnotics – alprazolam and diazepam, in turn, have higher activity at the α2 subunit compared to triazolam and temazepam, making them superior anxiolytic agents Modulation of the α1 subunit is associated with sedation, motor impairment, respiratory depression, amnesia, ataxia, and reinforcing behavior drug-seeking behavior Modulation of the α2 subunit is associated with anxiolytic activity and disinhibition For this reason, certain benzodiazepines may be better suited to treat insomnia than otherscitation needed

Benzodiazepine-like medicationsedit

Drugs that may prove more effective and safer than benzodiazepines for insomnia is an area of active research110 Nonbenzodiazepine sedative-hypnotic drugs, such as zolpidem Ambien, zaleplon, zopiclone Imovane, and eszopiclone Lunesta, are a class hypnotic medications that are similar to benzodiazepines in their mechanism of action, and indicated for mild to moderate insomnia Their effectiveness at improving time to sleeping is slight, and they have similar—though potentially less severe—side effect profiles compared to benzodiazepines111

Suvorexant is FDA approved for insomnia, characterized by difficulties with sleep onset and/or sleep maintenance112

Prescribing of nonbenzodiazepines has seen a general increase since their initial release on the US market in 1992, from 23% in 1993 among individuals with sleep disorders to 137% in 2010103

Antipsychoticsedit

The use of antipsychotics for insomnia, while common, is not recommended as the evidence does not demonstrate a benefit and the risk of adverse effects is significant113114 Concerns regarding side effects is greater in the elderly115

Alternative medicineedit

Some insomniacs use herbs such as valerian, chamomile, lavender, cannabis, hops, Withania somnifera, and passion-flower L-Arginine L-aspartate, S-adenosyl-L-homocysteine, and delta sleep-inducing peptide DSIP may also be helpful in alleviating insomnia116 It is unclear if acupuncture is useful117

Prognosisedit

A survey of 11 million residents in the United States found that those that reported sleeping about 7 hours per night had the lowest rates of mortality, whereas those that slept for fewer than 6 hours or more than 8 hours had higher mortality rates Getting 85 or more hours of sleep per night increased the mortality rate by 15% Severe insomnia – sleeping less than 35 hours in women and 45 hours in men – is associated with a 15% increase in mortality However, most of the increase in mortality from severe insomnia was discounted after controlling for co-morbid disorders After controlling for sleep duration and insomnia, use of sleeping pills was also found to be associated with an increased mortality rate118

The lowest mortality was seen in individuals who slept between six and a half and seven and a half hours per night Even sleeping only 45 hours per night is associated with very little increase in mortality Thus, mild to moderate insomnia for most people is associated with increased longevity and severe insomnia is associated only with a very small effect on mortality118 It is unclear why sleeping longer than 75 hours is associated with excess mortality118

Epidemiologyedit

Disability-adjusted life year for insomnia per 100,000 inhabitants in 2004   no data   less than 25   25–3025   3025–36   36–415   415–47   47–525   525–58   58–635   635–69   69–745   745–80   more than 80

Between 10% and 30% of adults have insomnia at any given point in time and up to half of people have insomnia in a given year738 About 6% of people have insomnia that is not due to another problem and lasts for more than a month7 People over the age of 65 are affected more often than younger people6 Females are more often affected than males3 Insomnia is 40% more common in women than in men119

There are higher rates of insomnia reported among university students compared to the general population120

Society and cultureedit

The topic of insomnia is discussed in many cultural contexts121122

The word insomnia is from Latin: in + somnus "without sleep" and -ia as nominalizing suffix

The popular press have published stories about people who supposedly never sleep, such as that of Paul Kern and Al Herpin; however, these stories are not accurate123

Referencesedit

  1. ^ a b c d "What Is Insomnia" NHLBI December 13, 2011 Retrieved 9 August 2016 
  2. ^ a b c "What Causes Insomnia" NHLBI December 13, 2011 Retrieved 9 August 2016 
  3. ^ a b c d e f g h "Dyssomnias" PDF WHO pp 7–11 Retrieved 2009-01-25 
  4. ^ a b c d "How Is Insomnia Treated" NHLBI December 13, 2011 Retrieved 9 August 2016 
  5. ^ a b c d e Qaseem, A; Kansagara, D; Forciea, MA; Cooke, M; Denberg, TD; Clinical Guidelines Committee of the American College of, Physicians 3 May 2016 "Management of Chronic Insomnia Disorder in Adults: A Clinical Practice Guideline From the American College of Physicians" Annals of Internal Medicine 165: 125–33 doi:107326/M15-2175 PMID 27136449 
  6. ^ a b c d e Wilson, JF 1 January 2008 "In the clinic Insomnia" Annals of Internal Medicine 148 1: ITC13–1–ITC13–16 doi:107326/0003-4819-148-1-200801010-01001 PMID 18166757 
  7. ^ a b c d e f g h i Roth, T 2007 "Insomnia: Definition, prevalence, etiology, and consequences" Journal of Clinical Sleep Medicine 3 5 Suppl: S7–10 PMC 1978319  PMID 17824495 
  8. ^ a b c Tasman, Allan; Kay, Jerald; Lieberman, Jeffrey A; First, Michael B; Riba, Michelle 2015 Psychiatry, 2 Volume Set 4 ed John Wiley & Sons p 4253 ISBN 9781118753361 
  9. ^ a b c Golub, R M 2012 "Insomnia" JAMA: The Journal of the American Medical Association 307 24: 2653–2653 doi:101001/jama20126219 PMID 22735439 
  10. ^ "How Is Insomnia Diagnosed" NHLBI December 13, 2011 Retrieved 9 August 2016 
  11. ^ Trauer, James M; Qian, Mary Y; Doyle, Joseph S; W Rajaratnam, Shantha M; Cunnington, David 9 June 2015 "Cognitive Behavioral Therapy for Chronic Insomnia" Annals of Internal Medicine 163: 191–204 doi:107326/M14-2841 PMID 26054060 
  12. ^ Attarian, Hrayr P 2003 Clinical Handbook of Insomnia Springer Science & Business Media p Chapter 1 ISBN 9781592596621 
  13. ^ "Sleep Wake Disorders " Diagnostic and statistical manual of mental disorders: DSM-5 5th ed Washington, DC: American Psychiatric Association, 2013 - Print
  14. ^ a b Roth, T; Roehrs, T 2003 "Insomnia: Epidemiology, characteristics, and consequences" Clinical cornerstone 5 3: 5–15 doi:101016/S1098-35970390031-7 PMID 14626537 
  15. ^ "Insomnia – sleeplessness, chronic insomnia, acute insomnia, mental " Archived from the original on March 29, 2008 Retrieved 2008-04-29 
  16. ^ "Acute Insomnia – What is Acute Insomnia" Sleepdisordersaboutcom Retrieved 2013-03-10 
  17. ^ Simon, Harvey "In-Depth Report: Causes of Chronic Insomnia" New York Times Retrieved 4 November 2011 
  18. ^ Consumer Reports; Drug Effectiveness Review Project January 2012 "Evaluating New Sleeping Pills Used to Treat: Insomnia Comparing Effectiveness, Safety, and Price" PDF Best Buy Drugs Consumer Reports Consumer Reports: 4 Retrieved 4 June 2013 
  19. ^ Kertesz, R S; Cote, K A 2011 "Event-Related Potentials During the Transition to Sleep for Individuals with Sleep-Onset Insomnia" Behavioral Sleep Medicine 9 2: 68–85 doi:101080/154020022011557989 PMID 21491230 
  20. ^ Doghramji, Karl 2007 Clinical Management of Insomnia Caddo, OK: Professional Communications, Inc p 28 ISBN 978-1-932610-14-7 
  21. ^ Morin, Charles 2003 Insomnia: A Clinician's Guide to Assessment and Treatment New York, New York: Kluwer Academic/Plenum Publishers p 16 ISBN 0-306-47750-5 
  22. ^ "What Happens When You Sleep" sleepfoundationorg Retrieved 2017-02-24 
  23. ^ Adler, C H; Thorpy, M J 2005 "Sleep issues in Parkinson's disease" Neurology 64 12 Suppl 3: S12–S20 doi:101212/WNL6412_suppl_3S12 PMID 15994219 
  24. ^ Harvey, A G; Tang, N 2011 "MisPerception of Sleep in Insomnia: A puzzle and a resolution" Psychological Bulletin 138 1: 77–101 doi:101037/a0025730 PMC 3277880  PMID 21967449 
  25. ^ Insomnia > Complications Mayo Clinic Retrieved on May 5, 2009
  26. ^ a b c d e f "Insomnia" University of Maryland Medical Center Retrieved 11 July 2013 
  27. ^ Taylor, DJ; Mallory, LJ; Lichstein, KL; Durrence, HH; Riedel, BW; Bush, AJ Feb 2007, "Comorbidity of chronic insomnia with medical problems", Sleep, Sleep, 30: 213–8, doi:101093/sleep/302213, PMID 17326547 
  28. ^ "Excessive daytime slepiness and insomnia" Arch Otolaryngol Retrieved 14 June 2014 
  29. ^ a b "Insomnia Causes" Mayo Clinic Retrieved 11 July 2013 
  30. ^ "Restless Legs Syndrome/Periodic Limb Movement Disorder" National Heart Lung and Blood Institute Retrieved 11 July 2013 
  31. ^ a b Ramakrishnan, K; Scheid, D C 2007 "Treatment options for insomnia" American family physician 76 4: 517–526 PMID 17853625 
  32. ^ a b Santoro, N; Epperson, CN; Mathews, SB September 2015 "Menopausal Symptoms and Their Management" Endocrinology and metabolism clinics of North America 44 3: 497–515 doi:101016/jecl201505001 PMC 4890704  PMID 26316239 
  33. ^ "What causes insomnia" National Heart, Lung, and Blood Institute Retrieved 11 July 2013 
  34. ^ Gelder, M, Mayou, R and Geddes, J 2005 Psychiatry 3rd ed New York: Oxford p 167, ISBN 0198528639
  35. ^ Bendz, L M; Scates, A C 2009 "Melatonin Treatment for Insomnia in Pediatric Patients with Attention-Deficit/Hyperactivity Disorder" Annals of Pharmacotherapy 44 1: 185–191 doi:101345/aph1M365 PMID 20028959 
  36. ^ Ouellet, M C; Beaulieu-Bonneau, S; Morin, C M 2006 "Insomnia in patients with traumatic brain injury: Frequency, characteristics, and risk factors" The Journal of head trauma rehabilitation 21 3: 199–212 doi:101097/00001199-200605000-00001 PMID 16717498 
  37. ^ a b Mendelson WB 2008 "New Research on Insomnia: Sleep Disorders May Precede or Exacerbate Psychiatric Conditions" Psychiatric Times 25
  38. ^ Schenkein, J; Montagna, P 2006 "Self management of fatal familial insomnia Part 1: What is FFI" MedGenMed : Medscape general medicine 8 3: 65 PMC 1781306  PMID 17406188 
  39. ^ The epidemiological survey of exercise-induced insomnia in chinese athletes Youqi Shi, Zhihong Zhou, Ke Ning, Jianhong LIU Athens 2004: Pre-Olympic Congress
  40. ^ Perry, Lacy 2004-10-12 HowStuffWorks "How Hangovers Work" Healthhowstuffworkscom Retrieved on 2011-11-20
  41. ^ Lee-chiong, Teofilo 24 April 2008 Sleep Medicine: Essentials and Review Oxford University Press, USA p 105 ISBN 0-19-530659-7 
  42. ^ Ashton, Heather 2005-05-01 "The diagnosis and management of benzodiazepine dependence" Current Opinion in Psychiatry 18 3: 249–255 doi:101097/01yco00001655946043484 ISSN 0951-7367 PMID 16639148 
  43. ^ Morin, Charles M; Bélanger, Lynda; Bastien, Célyne; Vallières, Annie 2005-01-01 "Long-term outcome after discontinuation of benzodiazepines for insomnia: a survival analysis of relapse" Behaviour Research and Therapy 43 1: 1–14 doi:101016/jbrat200312002 ISSN 0005-7967 PMID 15531349 
  44. ^ Poyares, Dalva; Guilleminault, Christian; Ohayon, Maurice M; Tufik, Sergio 2004-06-01 "Chronic benzodiazepine usage and withdrawal in insomnia patients" Journal of Psychiatric Research 38 3: 327–334 doi:101016/jjpsychires200310003 ISSN 0022-3956 PMID 15003439 
  45. ^ Asaad, T A; Ghanem, M H; Abdel Samee, A M; El–Habiby, M M 2011 "Sleep Profile in Patients with Chronic Opioid Abuse" Addictive Disorders & Their Treatment 10: 21–28 doi:101097/ADT0b013e3181fb2847 
  46. ^ Roth, Thomas 15 August 2007 "Insomnia: Definition, Prevalence, Etiology, and Consequences" Journal of Clinical Sleep Medicine : JCSM : official publication of the American Academy of Sleep Medicine 3 5 Suppl: S7–S10 ISSN 1550-9389 PMC 1978319  PMID 17824495 
  47. ^ Bonnet, Michael H 1 April 2009 "Evidence for the Pathophysiology of Insomnia" Sleep 32 4: 441–442 doi:101093/sleep/324441 ISSN 0161-8105 PMC 2663857  PMID 19413138 
  48. ^ Levenson, Jessica C; Kay, Daniel B; Buysse, Daniel J 22 January 2017 "The Pathophysiology of Insomnia" Chest 147 4: 1179–1192 doi:101378/chest14-1617 ISSN 0012-3692 PMC 4388122  PMID 25846534 
  49. ^ Mai, Evelyn; Buysse, Daniel J 1 January 2008 "Insomnia: Prevalence, Impact, Pathogenesis, Differential Diagnosis, and Evaluation" Sleep medicine clinics 3 2: 167–174 doi:101016/jjsmc200802001 ISSN 1556-407X PMC 2504337  PMID 19122760 
  50. ^ Shaver, JL; Woods, NF August 2015 "Sleep and menopause: a narrative review" Menopause New York, NY 22 8: 899–915 doi:101097/GME0000000000000499 PMID 26154276 
  51. ^ Lord, C; Sekerovic, Z; Carrier, J October 2014 "Sleep regulation and sex hormones exposure in men and women across adulthood" Pathologie-biologie 62 5: 302–10 doi:101016/jpatbio201407005 PMID 25218407 
  52. ^ Soldatos, CR; Dikeos, DG; Paparrigopoulos, TJ Jun 2000 "Athens Insomnia Scale: validation of an instrument based on ICD-10 criteria" Journal of Psychosomatic Research 48: 555–560 doi:101016/S0022-39990000095-7 PMID 11033374 
  53. ^ a b Passarella, S, Duong, M "Diagnosis and treatment of insomnia" 2008
  54. ^ Schutte-Rodin, Sharon; Broch, Lauren; Buysse, Daniel; Dorsey, Cynthia; Sateia, Michael 2015 "Clinical Guideline for the Evaluation and Management of Chronic Insomnia in Adults" PDF Journal of Clinical Sleep Medicine AASM p 488 Retrieved 30 July 2015 Actigraphy is indicated as a method to characterize circadian patterns or sleep disturbances in individuals with insomnia,  
  55. ^ a b c American College of Occupational and Environmental Medicine February 2014, "Five Things Physicians and Patients Should Question", Choosing Wisely: an initiative of the ABIM Foundation, American College of Occupational and Environmental Medicine, retrieved 24 February 2014 
  56. ^ Thorpy, Michael J October 2012 "Classification of Sleep Disorders" Neurotherapeutics 9 4: 687–701 doi:101007/s13311-012-0145-6 PMC 3480567  PMID 22976557 
  57. ^ a b c Wilson, S; Nutt, D; Alford, C; Argyropoulos, S; Baldwin, D; Bateson, A; Britton, T; Crowe, C; Dijk, D -J; Espie, C; Gringras, P; Hajak, G; Idzikowski, C; Krystal, A; Nash, J; Selsick, H; Sharpley, A; Wade, A 2010 "British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders" Journal of Psychopharmacology 24 11: 1577–1601 doi:101177/0269881110379307 PMID 20813762 
  58. ^ a b Luca, A; Luca, M; Calandra, C 2013 "Sleep disorders and depression: brief review of the literature, case report, and nonpharmacologic interventions for depression" Clinical interventions in aging 8: 1033–9 doi:102147/CIAS47230 PMC 3760296  PMID 24019746 
  59. ^ Wortelboer, U; Cohrs, S; Rodenbeck, A; Rüther, E 2002 "Tolerability of hypnosedatives in older patients" Drugs & aging 19 7: 529–539 doi:102165/00002512-200219070-00006 PMID 12182689 
  60. ^ "NIH State-of-the-Science Conference Statement on manifestations and management of chronic insomnia in adults" NIH consensus and state-of-the-science statements 22 2: 1–30 2005 PMID 17308547 
  61. ^ a b c Merrigan, Jill M; Buysse, Daniel J; Bird, Joshua C; Livingston, Edward H 2013 "Insomnia" JAMA 309 7: 733 doi:101001/jama2013524 PMID 23423421 
  62. ^ National Prescribing Service 2010-02-01 "Addressing hypnotic medicines use in primary care" NPS News, Vol 67
  63. ^ Kirkwood, C K 1999 "Management of insomnia" Journal of the American Pharmaceutical Association Washington,DC : 1996 39 5: 688–696; quiz 696–4 PMID 10533351 
  64. ^ Jespersen, KV; Koenig, J; Jennum, P; Vuust, P 13 August 2015 "Music for insomnia in adults" The Cochrane database of systematic reviews 8: CD010459 doi:101002/14651858CD010459pub2 PMID 26270746 
  65. ^ Lake, James A 31 October 2006 Textbook of Integrative Mental Health Care Thieme Medical Publishers p 313 ISBN 1-58890-299-4 
  66. ^ van Straten, A; Cuijpers, P February 2009 "Self-help therapy for insomnia: a meta-analysis" Sleep medicine reviews 13 1: 61–71 doi:101016/jsmrv200804006 PMID 18952469 
  67. ^ Lande, R G; Gragnani, C 2010 "Nonpharmacologic approaches to the management of insomnia" The Journal of the American Osteopathic Association 110 12: 695–701 PMID 21178150 
  68. ^ Kierlin, L November 2008 "Sleeping without a pill: nonpharmacologic treatments for insomnia" Journal of Psychiatric Practice 14 6: 403–7 doi:101097/01pra0000341896739266c PMID 19057243 
  69. ^ a b Ellis, J J, Hampson, S E, & Cropley, M M "Sleep hygiene or compensatory sleep practices: an examination of behaviors affecting sleep in older adults" 2002
  70. ^ Mitchell, M D; Gehrman, P; Perlis, M; Umscheid, C A 2012 "Comparative effectiveness of cognitive behavioral therapy for insomnia: A systematic review" BMC Family Practice 13: 40 doi:101186/1471-2296-13-40 PMC 3481424  PMID 22631616 
  71. ^ Jacobs, G D; Pace-Schott, E F; Stickgold, R; Otto, M W 2004 "Cognitive behavior therapy and pharmacotherapy for insomnia: a randomized controlled trial and direct comparison" PDF Archives of Internal Medicine 164 17: 1888–1896 doi:101001/archinte164171888 PMID 15451764 
  72. ^ Morin, C M; Colecchi, C; Stone, J; Sood, R; Brink, D 1999 "Behavioral and pharmacological therapies for late-life insomnia: A randomized controlled trial" JAMA: The Journal of the American Medical Association 281 11: 991–999 doi:101001/jama28111991 PMID 10086433 
  73. ^ Miller, K E 2005 "Cognitive Behavior Therapy vs Pharmacotherapy for Insomnia" American Family Physician Archived from the original on 2011-06-06 
  74. ^ Ong, J C; Ulmer, C S; Manber, R 2012 "Improving sleep with mindfulness and acceptance: A metacognitive model of insomnia" Behaviour Research and Therapy 50 11: 651–660 doi:101016/jbrat201208001 PMC 3466342  PMID 22975073 
  75. ^ Edinger, J D; Means, M K 2005 "Cognitive–behavioral therapy for primary insomnia" Clinical Psychology Review 25 5: 539–558 doi:101016/jcpr200504003 PMID 15951083 
  76. ^ a b Fox S, Fallows D 2005-10-05 Internet health resources Washington, DC: Pew Internet & American Life Project; 2003
  77. ^ Rabasca L 2000 "Taking telehealth to the next step" Monitor on Psychology 31: 36–37 doi:101037/e378852004-017 
  78. ^ Marks IM, Cavanagh K, Gega L 2007 Hands-on Help: Computer-Aided Psychotherapy Hove, England and New York: Psychology Press, ISBN 184169679X
  79. ^ a b Ritterband, L M; Gonder-Frederick, L A; Cox, D J; Clifton, A D; West, R W; Borowitz, S M 2003 "Internet interventions: In review, in use, and into the future" Professional Psychology: Research and Practice 34 5: 527–534 doi:101037/0735-7028345527 
  80. ^ Cheng, SK; Dizon, J 2012 "Computerised cognitive behavioural therapy for insomnia: a systematic review and meta-analysis" Psychotherapy and psychosomatics 81 4: 206–16 doi:101159/000335379 PMID 22585048 
  81. ^ Harrison C, Britt H 2009 "Insomnia" PDF Australian Family Physician 32: 283 
  82. ^ Qaseem, A; Kansagara, D; Forciea, MA; Cooke, M; Denberg, TD; Clinical Guidelines Committee of the American College of, Physicians 19 July 2016 "Management of Chronic Insomnia Disorder in Adults: A Clinical Practice Guideline From the American College of Physicians" Annals of Internal Medicine 165 2: 125–33 doi:107326/m15-2175 PMID 27136449 
  83. ^ Chong Y, Fryar, CD, and Gu, Q 2013 Prescription Sleep Aid Use Among Adults: United States, 2005–2010 Hyattsville, Md: US Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Health Statistics
  84. ^ Consumer Reports; Drug Effectiveness Review Project January 2012 "Evaluating Newer Sleeping Pills Used to Treat: Insomnia Comparing Effectiveness, Safety, and Price" PDF Best Buy Drugs Consumer Reports: 3, 8, 11 Retrieved 4 June 2013 
  85. ^ DrugBank: DB00366 Doxylamine Drugbankca Retrieved on 2011-11-20
  86. ^ a b c Brasure, M; MacDonald, R; Fuchs, E; Olson, CM; Carlyle, M; Diem, S; Koffel, E; Khawaja, IS; Ouellette, J; Butler, M; Kane, RL; Wilt, TJ December 2015 "Management of Insomnia Disorder" PMID 26844312 
  87. ^ Conn, D K; Madan, R 2006 "Use of Sleep-Promoting Medications in Nursing Home Residents" Drugs & Aging 23 4: 271–287 doi:102165/00002512-200623040-00001 PMID 16732687 
  88. ^ Lyseng-Williamson, KA November 2012 "Melatonin prolonged release: in the treatment of insomnia in patients aged ≥55 years" Drugs & aging 29 11: 911–23 doi:101007/s40266-012-0018-z PMID 23044640 
  89. ^ Lemoine, P; Zisapel, N April 2012 "Prolonged-release formulation of melatonin Circadin for the treatment of insomnia" Expert opinion on pharmacotherapy 13 6: 895–905 doi:101517/146565662012667076 PMID 22429105 
  90. ^ Sánchez-Barceló, Emilio; Mediavilla, Maria; Reiter, Russel J 2011 "Clinical Uses of Melatonin in Pediatrics" International Journal of Pediatrics 2011: 1–11 doi:101155/2011/892624 
  91. ^ Bertschy, G; Ragama-Pardos, E; Muscionico, M; Aït-Ameur, A; Roth, L; Osiek, C; Ferrero, F O 2005 "Trazodone addition for insomnia in venlafaxine-treated, depressed inpatients: A semi-naturalistic study" Pharmacological Research 51 1: 79–84 doi:101016/jphrs200406007 PMID 15519538 
  92. ^ Winokur, A; Demartinis Na, 3; McNally, D P; Gary, E M; Cormier, J L; Gary, K A 2003 "Comparative effects of mirtazapine and fluoxetine on sleep physiology measures in patients with major depression and insomnia" The Journal of Clinical Psychiatry 64 10: 1224–1229 doi:104088/JCPv64n1013 PMID 14658972 
  93. ^ Schittecatte, M; Dumont, F; Machowski, R; Cornil, C; Lavergne, F; Wilmotte, J 2002 "Effects of mirtazapine on sleep polygraphic variables in major depression" Neuropsychobiology 46 4: 197–201 doi:101159/000067812 PMID 12566938 
  94. ^ Strat YL; Gorwood, P September 2008 "Agomelatine, an innovative pharmacological response to unmet needs" Journal of Psychopharmacology 22 suppl 7: 4–8 doi:101177/0269881108092593 PMID 18753276 
  95. ^ "Summary of Product Characteristics" PDF European Medicine Agency Retrieved 2013-10-14 
  96. ^ "VALDOXAN® Product Information" PDF TGA eBusiness Services Servier Laboratories Pty Ltd 2013-09-23 Retrieved 2013-10-14 
  97. ^ Novartis drops future blockbuster agomelatine Scrip Intelligence, Oct 25 2011 retrieved Oct 30, 2011
  98. ^ Bentham, Clara 2006-03-29 "Servier and Novartis sign licensing agreement for agomelatine, a novel treatment for depression" Servier UK Archived from the original on 16 April 2009 Retrieved 2009-05-15 
  99. ^ Temazepam Websters-online-dictionaryorg Retrieved on 2011-11-20
  100. ^ a b Buscemi, N; Vandermeer, B; Friesen, C; Bialy, L; Tubman, M; Ospina, M; Klassen, T P; Witmans, M 2007 "The Efficacy and Safety of Drug Treatments for Chronic Insomnia in Adults: A Meta-analysis of RCTs" Journal of General Internal Medicine 22 9: 1335–1350 doi:101007/s11606-007-0251-z PMC 2219774  PMID 17619935 
  101. ^ Ohayon, M M; Caulet, M 1995 "Insomnia and psychotropic drug consumption" Progress in neuro-psychopharmacology & biological psychiatry 19 3: 421–431 doi:101016/0278-58469400023-B PMID 7624493 
  102. ^ "What's wrong with prescribing hypnotics" Drug and therapeutics bulletin 42 12: 89–93 2004 doi:101136/dtb2004421289 PMID 15587763 
  103. ^ a b Kaufmann, Christopher N; Spira, Adam P; Alexander, G Caleb; Rutkow, Lainie; Mojtabai, Ramin 2015 "Trends in prescribing of sedative-hypnotic medications in the USA: 1993–2010" Pharmacoepidemiology and Drug Safety 25: 637–45 doi:101002/pds3951 ISSN 1099-1557 PMID 26711081 
  104. ^ Glass, J; Lanctôt, K L; Herrmann, N; Sproule, B A; Busto, U E 2005 "Sedative hypnotics in older people with insomnia: Meta-analysis of risks and benefits" BMJ 331 7526: 1169 doi:101136/bmj3862376858847 PMC 1285093  PMID 16284208 
  105. ^ Tsoi, W F 1991 "Insomnia: Drug treatment" Annals of the Academy of Medicine, Singapore 20 2: 269–272 PMID 1679317 
  106. ^ Montplaisir, J 2000 "Treatment of primary insomnia" Canadian Medical Association Journal 163 4: 389–391 PMC 80369  PMID 10976252 
  107. ^ Carlstedt, Roland A 13 December 2009 Handbook of Integrative Clinical Psychology, Psychiatry, and Behavioral Medicine: Perspectives, Practices, and Research Springer pp 128–130 ISBN 0-8261-1094-0 
  108. ^ Lader, Malcolm Harold; P Cardinali, Daniel; R Pandi-Perumal, S 22 March 2006 Sleep and sleep disorders: a neuropsychopharmacological approach Georgetown, Tex: Landes Bioscience/Eurekahcom p 127 ISBN 0-387-27681-5 
  109. ^ Authier, N; Boucher, A; Lamaison, D; Llorca, P M; Descotes, J; Eschalier, A 2009 "Second Meeting of the French CEIP Centres d'Évaluation et d'Information sur la Pharmacodépendance Part II: Benzodiazepine Withdrawal" Thérapie 64 6: 365–370 doi:102515/therapie/2009051 PMID 20025839 
  110. ^ Rosenberg, R P 2006 "Sleep Maintenance Insomnia: Strengths and Weaknesses of Current Pharmacologic Therapies" Annals of Clinical Psychiatry 18 1: 49–56 doi:101080/10401230500464711 PMID 16517453 
  111. ^ Huedo-Medina, T B; Kirsch, I; Middlemass, J; Klonizakis, M; Siriwardena, A N 2012 "Effectiveness of non-benzodiazepine hypnotics in treatment of adult insomnia: Meta-analysis of data submitted to the Food and Drug Administration" BMJ 345: e8343 doi:101136/bmje8343 PMC 3544552  PMID 23248080 
  112. ^ "Highlights of prescribing information" PDF 
  113. ^ American Psychiatric Association September 2013, "Five Things Physicians and Patients Should Question", Choosing Wisely: an initiative of the ABIM Foundation, American Psychiatric Association, retrieved 30 December 2013 , which cites
    • "Consensus Development Conference on Antipsychotic Drugs and Obesity and Diabetes" Diabetes Care 27 2: 596–601 1 February 2004 doi:102337/diacare272596 PMID 14747245 
    • Maglione, M; Maher, AR; Hu, J; Wang, Z; Shanman, R; Shekelle, PG; Roth, B; Hilton, L; Suttorp, MJ; Ewing, BA; Motala, A; Perry, T Sep 2011 "Off-Label Use of Atypical Antipsychotics: An Update" PMID 22132426 
    • Nasrallah, HA Jan 2008 "Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles" Molecular Psychiatry 13 1: 27–35 doi:101038/sjmp4002066 PMID 17848919 
  114. ^ Coe, HV; Hong, IS May 2012 "Safety of low doses of quetiapine when used for insomnia" The Annals of pharmacotherapy 46 5: 718–22 doi:101345/aph1Q697 PMID 22510671 
  115. ^ Conn, DK; Madan, R 2006 "Use of sleep-promoting medications in nursing home residents : risks versus benefits" Drugs & aging 23 4: 271–87 doi:102165/00002512-200623040-00001 PMID 16732687 
  116. ^ Billiard M, Kent A 2003 Sleep: physiology, investigations, medicine pp 275–7 ISBN 978-0-306-47406-4 
  117. ^ Cheuk, DK; Yeung, WF; Chung, KF; Wong, V 12 September 2012 "Acupuncture for insomnia" The Cochrane database of systematic reviews 9: CD005472 doi:101002/14651858CD005472pub3 PMID 22972087 
  118. ^ a b c Kripke, D F; Garfinkel, L; Wingard, D L; Klauber, M R; Marler, M R 2002 "Mortality associated with sleep duration and insomnia" Archives of General Psychiatry 59 2: 131–136 doi:101001/archpsyc592131 PMID 11825133 
  119. ^ "Several Sleep Disorders Reflect Gender Differences" Psychiatric News 42 8: 40 2007 
  120. ^ Jiang, X-l; Zheng, X-y; Yang, J; Ye, C-p; Chen, Y-y; Zhang, Z-g; Xiao, Z-j 2015-12-01 "A systematic review of studies on the prevalence of insomnia in university students" Public Health 129 12: 1579–1584 doi:101016/jpuhe201507030 ISSN 1476-5616 PMID 26298588 
  121. ^ Summers-Bremner, Eluned 2010 Insomnia : a cultural history London: Reaktion ISBN 1861896549 
  122. ^ Brigitte Steger 2009 "Insomnia: A Cultural History review" Bulletin of the History of Medicine 83 2: 385–386 doi:101353/bhm00210 
  123. ^ Jim, Horne, 2016 Sleeplessness Assessing Sleep Need in Society Today p 114 ISBN 9783319305721 

External linksedit

Classification
  • ICD-10: F510, G470
  • ICD-9-CM: 30742, 30741, 3270, 78051, 78052
  • MeSH: D007319
  • DiseasesDB: 26877
External resources
  • MedlinePlus: 000805
  • eMedicine: med/2698
  • Patient UK: Insomnia
  • Ellis, J J; Hampson, S E; Cropley, M M 2002 "Sleep hygiene or compensatory sleep practices: an examination of behaviours affecting sleep in older adults" Psychology, Health & Medicine 7 2: 156–161 doi:101080/13548500120116094 
  • Passarella, S, & Duong, M 2008 Diagnosis and treatment of insomnia American Journal Of Health-System Pharmacy, 6510, 927-934 doi:102146/ajhp060640

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