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Immunoglobulin domain

immunoglobulin domain, immunoglobulin domain structure
The immunoglobulin domain is a type of protein domain that consists of a 2-layer sandwich of 7-9 antiparallel β-strands arranged in two β-sheets with a Greek key topology,[1][2] consisting of about 125 amino acids

The backbone switches repeatedly between the two β-sheets Typically, the pattern is N-terminal β-hairpin in sheet 1-β-hairpin in sheet 2-β-strand in sheet 1-C-terminal β-hairpin in sheet 2 The cross-overs between sheets form an "X", so that the N- and C-terminal hairpins are facing each other

Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions Examples include antibodies, the giant muscle kinase titin, and receptor tyrosine kinases Immunoglobulin-like domains may be involved in protein–protein and protein–ligand interactions[3]

Contents

  • 1 Examples
  • 2 See also
  • 3 References
  • 4 External links

Examples

Human genes encoding proteins containing the immunoglobulin domain include:

  • A1BG
  • ACAM
  • ADAMTSL1
  • ADAMTSL3
  • AGER
  • ALCAM
  • AMIGO1
  • AMIGO2
  • AXL
  • BCAM
  • BOC
  • BSG
  • BTLA
  • C10orf72
  • C20orf102
  • CADM1
  • CADM3
  • CD200
  • CD22
  • CD276
  • CD33
  • CD4
  • CDON
  • CEACAM1
  • CEACAM16
  • CEACAM20
  • CEACAM21
  • CEACAM5
  • CEACAM6
  • CEACAM8
  • CHL1
  • CILP
  • CNTFR
  • CNTN1
  • CNTN2
  • CNTN3
  • CNTN4
  • CNTN5
  • CNTN6
  • CSF1R
  • DSCAM
  • DSCAML1
  • EMB
  • F11R
  • FAIM3
  • FCAR
  • FCER1A
  • FCGR1A
  • FCGR2A
  • FCGR2B
  • FCGR2C
  • FCGR3A
  • FCGR3B
  • FCRH1
  • FCRH3
  • FCRH4
  • FCRL1
  • FCRL2
  • FCRL3
  • FCRL4
  • FCRL5
  • FCRL6
  • FCRLA
  • FGFR1
  • FGFR2
  • FGFR3
  • FGFR4
  • FGFRL1
  • FLT1
  • FLT3
  • FLT4
  • FSTL4
  • FSTL5
  • GP6
  • GPA33
  • GPR116
  • GPR125
  • HEPACAM
  • HLA-DMA
  • HLA-DMB
  • HLA-DQB
  • HLA-DQB1
  • HMCN1
  • HNT
  • HSPG2
  • HYST2477
  • ICAM3
  • ICAM5
  • IGHA1
  • IGHD
  • IGHE
  • IGSF10
  • IGSF11
  • IGSF2
  • IGSF21
  • IGSF3
  • IGSF9
  • IL11RA
  • IL1R1
  • IL1R2
  • IL1RAPL1
  • IL1RAPL2
  • IL1RL1
  • IL1RL2
  • IL6R
  • JAM2
  • JAM3
  • KIR-123FM
  • KIR2DL1
  • KIR2DL2
  • KIR2DL3
  • KIR2DL4
  • KIR2DL5A
  • KIR2DL5B
  • KIR2DLX
  • KIR2DS1
  • KIR2DS2
  • KIR2DS3
  • KIR2DS4
  • KIR2DS5
  • KIR3DL1
  • KIR3DL2
  • KIR3DL3
  • KIR3DS1
  • KIT
  • L1CAM
  • LAG3
  • LILRA1
  • LILRA2
  • LILRA3
  • LILRA4
  • LILRA5
  • LILRA6
  • LILRB1
  • LILRB2
  • LILRB3
  • LILRB4
  • LILRB5
  • LILRP2
  • LRIG1
  • LRIG2
  • LRIG3
  • LRIT1
  • LRRC4
  • LSAMP
  • MAG
  • MALT1
  • MCAM
  • MDGA1
  • MDGA2
  • MERTK
  • MFAP3
  • MIR
  • MIR
  • MXRA5
  • MYBPC3
  • MYOM1
  • MYOM3
  • NCA
  • NCAM1
  • NCAM2
  • NEGR1
  • NEO1
  • NFASC
  • NOPE
  • NPHS1
  • NPTN
  • NRCAM
  • NRG1
  • NT
  • NTRK3
  • OBSCN
  • OBSL1
  • OPCML
  • PAPLN
  • PDGFRA
  • PDGFRB
  • PDGFRL
  • PECAM1
  • PRODH2
  • PSG1
  • PSG10
  • PSG11
  • PSG11s'
  • PSG2
  • PSG3
  • PSG4
  • PSG5
  • PSG6
  • PSG7
  • PSG8
  • PSG9
  • PTGFRN
  • PTK7
  • PTPRD
  • PTPRK
  • PTPRM
  • PTPRS
  • PTPsigma
  • PUNC
  • PVR
  • PVRL1
  • PVRL2
  • PVRL4
  • RAGE
  • SCN1B
  • SDK1
  • SDK2
  • SEMA3A
  • SEMA3B
  • SEMA3E
  • SEMA3F
  • SEMA3G
  • SEMA4D
  • SIGLEC1
  • SIGLEC10
  • SIGLEC11
  • SIGLEC12
  • SIGLEC14
  • SIGLEC6
  • SIGLEC7
  • SIGLEC8
  • SIRPG
  • THY1
  • TIE1
  • TMIGD1
  • TMIGD2
  • TTN
  • TYRO3
  • UNC5D
  • VCAM1
  • VSIG1
  • VSIG2
  • VSIG4
  • hEMMPRIN
  • kir3d

See also

  • Immunoglobulin superfamily

References

  1. ^ Bork P, Holm L, Sander C September 1994 "The immunoglobulin fold Structural classification, sequence patterns and common core" J Mol Biol 242 4: 309–20 doi:101006/jmbi19941582 PMID 7932691 
  2. ^ Brümmendorf T, Rathjen FG 1995 "Cell adhesion molecules 1: immunoglobulin superfamily" Protein Profile 2 9: 963–1108 PMID 8574878 
  3. ^ Williams AF, Barclay AN 1988 "The immunoglobulin superfamily—domains for cell surface recognition" Annu Rev Immunol 6: 381–405 doi:101146/annureviy06040188002121 PMID 3289571 

External links

  • SCOP listing of immunoglobulin domains of known structure

This article incorporates text from the public domain Pfam and InterPro IPR013151

antibody domain regions, antibody domain variability, antibody domains, antibody domains igg1, fc human immunoglobulin domain attached, immunoglobulin domain, immunoglobulin domain structure


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Immunoglobulin domain


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