Sat . Sat Jul 2018

ICI-164384


ICI-164384, also known as N-n-butyl-N-methyl-11-3,17β-dihydroxyestra-1,3,510-trien-7α-ylundecanamide, is a steroidal antiestrogen and a synthetic derivative of estradiol which is closely related to fulvestrant and was never marketed It is a silent antagonist of the estrogen receptor ER with no intrinsic estrogenic activity and hence is a pure antiestrogen, unlike selective estrogen receptor modulators SERMs like tamoxifen The drug was under development by AstraZeneca for the treatment of breast cancer but was discontinued in favor of fulvestrant, which is very similar to ICI-164384 but is more potent in comparison

See also

  • Cytestrol acetate
  • Ethamoxytriphetol
  • TAS-108

References

  1. ^ a b Edward J Pavlik 6 December 2012 Estrogens, Progestins, and Their Antagonists: Health Issues Springer Science & Business Media pp 133– ISBN 978-1-4612-4096-9 
  2. ^ a b A Howell 15 October 1990 The Role of Antihormones CRC Press pp 119–124 ISBN 978-1-85070-295-5 
  3. ^ https://adisinsightspringercom/drugs/800000792
  4. ^ William R Miller; James N Ingle 8 March 2002 Endocrine Therapy in Breast Cancer CRC Press pp 64– ISBN 978-0-203-90983-6 

External links

  • ICI-164384 - AdisInsight





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