Hypersensitive sitednase hyper sensitive sites, hyper sensitive sites
In genetics a hypersensitive site is a short region of chromatin and is detected by its super sensitivity to cleavage by DNase I and other various nucleases DNase II and micrococcal nucleases In a hypersensitive site, the nucleosomal structure is less compacted, increasing the availability of the DNA to binding by proteins, such as transcription factors and DNase I These sites account for many inherited tendencies
Hypersensitive sites are found on every active gene, and many of these genes often have more than one hypersensitive site Most often, hypersensitive sites are found only in chromatin of cells in which the associated gene is being expressed, and do not occur when the gene is inactive
In DNA being transcribed, 5'hypersensitive sites appear before transcription begins, and the DNA sequences within the hypersensitive sites are required for gene expression Note: hypersensitive sites precede active promoters
Hypersensitive sites are generated as a result of the binding of transcription factors that displace histone octamers
They can also be located by indirect end labelling A fragment of DNA is cut once at the hypersensitive site with DNase and at another site with a restriction enzyme The distance from the known restriction site to the DNase cut is then measured to give the location
- ^ Wang, YM; Zhou, P; Wang, LY; Li, ZH; Zhang, YN; Zhang, YX "Correlation between DNase I hypersensitive site distribution and gene expression in HeLa S3 cells" PLoS One 7: e42414 doi:101371/journalpone0042414 PMC 3416863 PMID 22900019
- ^ Pennisi, Elizabeth 7 September 2012 "ENCODE Project Writes Eulogy for Junk DNA" Science 337: 1159–1161 doi:101126/science33760991159 PMID 22955811
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dnase hyper sensitive sites, hyper sensitive sites
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