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Hormone response element


A hormone response element HRE is a short sequence of DNA within the promoter of a gene that is able to bind to a specific hormone receptor complex and therefore regulate transcription The sequence is most commonly a pair of inverted repeats separated by three nucleotides, which also indicates that the receptor binds as a dimer Specifically, HRE responds to steroid hormones, as the activated steroid receptor is the transcription factor binding HRE This regulates the transcription of genes signalled by the steroid hormone

A gene may have many different response elements, allowing complex control to be exerted over the level and rate of transcription

HRE are used in transgenic animal cells as inducers of gene expression

Examples of HREs include estrogen response elements EREs and androgen response elements AREs

References

  1. ^ "Steroid Hormone Receptors and their Response Elements" Retrieved 2006-11-09 
  2. ^ Monty Krieger; Matthew P Scott; Matsudaira, Paul T; Lodish, Harvey F; Darnell, James E; Lawrence Zipursky; Kaiser, Chris; Arnold Berk 2003 Molecular Cell Biology, Fifth Edition San Francisco: W H Freeman p 973 pages ISBN 0-7167-4366-3 




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