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Histoplasma capsulatum

histoplasma capsulatum, histoplasma capsulatum infection
Histoplasma capsulatum is a species of dimorphic fungi

Histoplasma capsulatum is "distributed worldwide, except in Antarctica, but most often associated with river valleys" and occurs chiefly in the "central and eastern United States" followed by "Central and South America, and other areas of the world" It is most prevalent in the Ohio and Mississippi river valleys It was discovered by Samuel Taylor Darling in 1906


  • 1 Growth and morphology
  • 2 Geographic distribution
  • 3 Spectrum of disease
  • 4 Ecology and epidemiology
  • 5 Additional images
  • 6 See also
  • 7 References
  • 8 External links

Growth and morphology

Histoplasma capsulatum is an ascomycetous fungus closely related to Blastomyces dermatitidis It is potentially sexual, and its sexual state, Ajellomyces capsulatus, can readily be produced in culture, though it has not been directly observed in nature As mentioned above, H capsulatum groups with B dermatitidis and the South American pathogen Paracoccidioides brasiliensis in the recently recognized fungal family Ajellomycetaceae It is dimorphic and switches from a mould-like filamentous growth form in the natural habitat to a small budding yeast form in the warm-blooded animal host

Histoplasma capsulatum has two mating types "+" and "–", as with B dermatitidis The great majority of North American isolates belong to a single genetic type but a study of multiple genes suggests a recombining, sexual population A recent analysis has suggested that the prevalent North American genetic type and a less common type should be considered separate phylogenetic species, distinct from H capsulatum isolates obtained in Central and South America and other parts of the world These entities are temporarily designated NAm1 the rare type, which includes a famous experimental isolate designated "the Downs strain" and NAm2 the common type There is as yet no well established clinical or geographic distinction among these two genetic groups

In its asexual form, the fungus grows as a colonial microfungus strongly similar in macromorphology to B dermatitidis A microscopic examination shows a marked distinction:H capsulatum produces two types of conidia, globose macroconidia, 8–15 µm, with distinctive tuberculate or finger-like cell wall ornamentation, and ovoid microconidia, 2–4 µm, which appear smooth or finely roughened It is not clear whether one or both of these conidial types is more important than the other as the principal main infectious particles They form on individual short stalks and readily become airborne when the colony is disturbed Ascomata of the sexual state are 80–250 µm, and are very similar in appearance and anatomy to those described above for B dermatitidis The ascospores are similarly minute, averaging 15 µm

The budding yeast cells formed in infected tissues are small ca 2–4 µm and are characteristically seen forming in clusters within phagocytic cells, including histiocytes and other macrophages, as well as monocytes An African phylogenetic species, H duboisii, often but not always forms larger yeast cells to 15 µm

Geographic distribution

Histoplasma capsulatum is "distributed worldwide, except in Antarctica, but most often associated with river valleys" and occurs chiefly in the "central and eastern United States" followed by "Central and South America, and other areas of the world" It is most prevalent in the Ohio and Mississippi river valleys

The enzootic and endemic zones of H capsulatum can be roughly divided into core areas, where the fungus occurs widely in soil or on vegetation contaminated by bird droppings or equivalent organic inputs, and peripheral areas, where the fungus occurs relatively rarely in association with soil but is still found abundantly in heavy accumulations of bat or bird guano in enclosed spaces such as caves, buildings, and hollow trees The principal core area for this species includes the valleys of the Mississippi, Ohio and Potomac rivers in the USA as well as a wide span of adjacent areas extending from Kansas, Illinois, Indiana and Ohio in the north to Mississippi, Louisiana and Texas in the south In some areas, such as Kansas City, skin testing with the histoplasmin antigen preparation shows that 80–90 % of the resident population have an antibody reaction to H capsulatum, probably indicating prior subclinical infection Northern US states such as Minnesota, Michigan, New York and Vermont are peripheral areas for histoplasmosis, but have scattered counties where 5–19 % of lifetime residents show exposure to H capsulatum One New York county, St Lawrence county across the St Lawrence River from the Cornwall– Preston – Brockville area of Ontario, Canada shows exposures over 20%

The distribution of H capsulatum in Canada is not as well documented as in the US The St Lawrence Valley is probably the best known endemic region based both on case reports and on a number of skin test reaction studies that were done between 1945 and 1970 The Montreal area is a particularly well documented endemic focus, not just in the agricultural regions surrounding the city but also within the city itself The Mount Royal area in central Montreal, especially the north and east sides of Mt Royal Park, showed exposure rates between 20 and 50% in schoolchildren and locally lifetime-resident university students A particularly high rate of 793% exposure was shown in St Thomas, Ontario, south of London, Ontario, after 7 local residents had died of histoplasmosis in 1957 Based on numerous small regional studies, histoplasmin skin test reactors form ca 10–50 % of the population in much of southern Ontario and in Quebec’s St Lawrence Valley, ca 5% in southern Manitoba and some northerly parts of Quebec eg, Abitibi-Témiscamingue, and ca 1% in Nova Scotia Exposure of aboriginal Canadians occurs remarkably far north in Quebec, but has not been reported in similar boreal biogeoclimatic zones in many other parts of Canada Recently and remarkably, a cluster of four indigenously acquired cases of histoplasmosis was shown to be associated with a golf course in suburban Edmonton, Alberta Examination suggested that local soil was the source

Spectrum of disease

Histoplasmosis is usually a subclinical infection that does not come to the attention of the person involved The organism tends to remain alive in the scattered pulmonary calcifications; therefore, some cases are detected by emergence of serious infection when a patient becomes immunocompromised, perhaps decades later Frank cases are most often seen as acute pulmonary histoplasmosis, a disease that resembles acute pneumonia but is usually self-limited It is most often seen in children newly exposed to H capsulatum or in heavily exposed individuals Erythematous skin conditions arising from antigen reactions may complicate the disease, as may myalgias, arthralgias, and rarely, arthritic conditions Emphysema sufferers may contract chronic cavitary pulmonary histoplasmosis as a disease complication; eventually the cavity formed may be occupied by an Aspergillus fungus ball aspergilloma, potentially leading to massive hemoptysis Another uncommon form of histoplasmosis is a slowly progressing condition known as granulomatous mediastinitis, in which the lymph nodes in the mediastinal cavity between the lungs become inflamed and ultimately necrotic; the swollen nodes or draining fluid may ultimately affect the bronchi, the superior vena cava, the esophagus or the pericardium A particularly dangerous condition is mediastinal fibrosis, in which a subset of individuals with granulomatous mediastinitis develop an uncontrolled fibrotic reaction that may press on the lungs or the bronchi, or may cause right heart failure There are a number of other rare pulmonary manifestations of histoplasmosis

Histoplasmosis, like blastomycosis, may disseminate haematogenously to infect internal organs and tissues, but it does so in a very low proportion of cases, and half or more of these dissemination cases involve immunocompromise Unlike blastomycosis, histoplasmosis is a recognized AIDS-defining illness in people with HIV infection; disseminated histoplasmosis affects approximately 5% of AIDS patients with CD4+ cell counts <150 cells/µL in highly endemic areas The incidence of this condition dropped significantly after introduction of current anti-HIV therapies Other conditions very uncommonly associated with H capsulatum include endocarditis and peritonitis

Ecology and epidemiology

Histoplasma capsulatum appears to be strongly associated with the droppings of certain bird species as well as bats A mixture of these droppings and certain soil types is particularly conducive to proliferation In highly endemic areas there is a strong association with soil under and around chicken houses, and with areas where soil or vegetation has become heavily contaminated with faecal material deposited by flocking birds such as starlings and blackbirds Bird roosting areas that are Histoplasma-free appear to be lower in nitrogen, phosphorus, organic matter and moisture than contaminated roosting areas Interestingly, the guano of gulls and other colonially nesting water-associated birds is rarely connected to histoplasmosis Bat dwellings, including caves, attics and hollow trees, are classic H capsulatum habitats Histoplasmosis outbreaks are typically associated with cleaning guano accumulations or clearing guano-covered vegetation, or with exploration of bat caves In addition, however, outbreaks may be associated with wind-blown dust liberated by construction projects in endemic areas:a classic outbreak is one associated with intense construction activity, including subway construction, in Montreal in 1963

As with blastomycosis, a good understanding of the precise ecological affinities of H capsulatum is greatly complicated by the difficulty of isolating the fungus directly from nature Again, the mouse passage procedure originally devised by Emmons must be used A direct PCR technique for detection of H capsulatum in soil has been published As mentioned above, H capsulatum appears particularly likely to cause clinical disease in young children, persons working in sites contaminated by conducive bird or bat droppings, persons exposed to construction dust raised from contaminated sites, immunocompromised patients, and emphysema sufferers Elimination of the agent from contaminated soils typically involves the use of toxic fumigants with limited success

Additional images

See also

  • Fungi portal
  • Blastomyces
  • Coccidioides


  1. ^ a b Chiller, Tom M 2016, "Histoplasmosis", CDC Yellow Book:CDC Health Information for International Travel 
  2. ^ a b c d CDC 2014, Fungal Diseases > Global fungal diseases > Preventing Deaths from Histoplasmosis 
  3. ^ Untereiner, WA; Scott, JA; Naveau, FA; Bachewich, J 2002 "Phylogeny of Ajellomyces, Polytolypa and Spiromastix Onygenaceae inferred from rDNA sequence and non-molecular data" Studies in Mycology 47:25–35 
  4. ^ Untereiner, WA; Scott, JA; Naveau, FA; Sigler, L; Bachewich, J; Angus, A 2004 "The Ajellomycetaceae, a new family of vertebrate-associated Onygenales" Mycologia 96 4:812–821 doi:102307/3762114 PMID 21148901 
  5. ^ Karimi, K; Wheat, LJ; Connolly, P; Cloud, G; Hajjeh, R; Wheat, E; Alves, K; Lacaz Cd Cda, S; Keath, E 1 December 2002 "Differences in histoplasmosis in patients with acquired immunodeficiency syndrome in the United States and Brazil" The Journal of Infectious Diseases 186 11:1655–1660 doi:101086/345724 PMID 12447743 
  6. ^ a b c Kasuga, T; White, TJ; Koenig, G; McEwen, J; Restrepo, A; Castañeda, E; Da Silva Lacaz, C; Heins-Vaccari, EM; De Freitas, RS; Zancopé-Oliveira, RM; Qin, Z; Negroni, R; Carter, DA; Mikami, Y; Tamura, M; Taylor, ML; Miller, GF; Poonwan, N; Taylor, JW 2003 "Phylogeography of the fungal pathogen Histoplasma capsulatum" Molecular Ecology 12 12:3383–401 doi:101046/j1365-294x200301995x PMID 14629354 
  7. ^ a b c d e f g h Kwon-Chung, K June; Bennett, Joan E 1992 Medical mycology Philadelphia:Lea & Febiger ISBN 0812114639 
  8. ^ Chamany, S; Mirza, SA; Fleming, JW; Howell, JF; Lenhart, SW; Mortimer, VD; Phelan, MA; Lindsley, MD; Iqbal, NJ; Wheat, LJ; Brandt, ME; Warnock, DW; Hajjeh, RA 2004 "A large histoplasmosis outbreak among high school students in Indiana, 2001" The Pediatric Infectious Disease Journal 23 10:909–14 doi:101097/01inf000014173860845da PMID 15602189 
  9. ^ Stobierski, MG; Hospedales, CJ; Hall, WN; Robinson-Dunn, B; Hoch, D; Sheill, DA 1996 "Outbreak of histoplasmosis among employees in a paper factory--Michigan, 1993" Journal of Clinical Microbiology 34 5:1220–1223 PMC 228985  PMID 8727906 
  10. ^ Guy, R; Roy, O 1949 "Histoplasmin sensitivity; preliminary observations in a group of school children in the Province of Quebec" Canadian Journal of Public Health 40 2:68–71 PMID 18113223 
  11. ^ a b Leznoff, A; Frank, H; Taussig, A; Brandt, JL 1969 "The focal distribution of histoplasmosis in Montreal" Canadian Journal of Public Health 60 8:321–5 PMID 5806145 
  12. ^ a b MacEachern, EJ; McDonald, JC 1971 "Histoplasmin sensitivity in McGill University students" Canadian Journal of Public Health 62 5:415–422 PMID 5137623 
  13. ^ a b Haggar, RA; Brown, EL; Toplack, NJ 1957 "Histoplasmosis in South Western Ontario" Canadian Medical Association Journal 77:855–861 
  14. ^ Rostocka, M; Hiltz, JE 1966 "Histoplasmin skin sensitivity in Nova Scotia" Canadian Journal of Public Health 57 9:413–418 PMID 5981243 
  15. ^ Hoff, B; Fogle, B 1970 "Case report Histoplasmosis in a dog" Canadian Veterinary Journal 11 7:145–148 
  16. ^ Mochi, A; Edwards, PQ 1952 "Geographical distribution of histoplasmosis and histoplasmin sensitivity" Bulletin of the World Health Organization 5 3:259–291 PMC 2554039  PMID 14935779 
  17. ^ Guy, R; Panisset, M; Frappier, A 1949 "Histoplasmin sensitivity; a brief study of the incidence of hypersensitivity to histoplasmin in an Indian tribe of northern Quebec" Canadian Journal of Public Health 40 7:306–309 PMID 18133141 
  18. ^ Schaefer, O 1966 "Pulmonary miliary calcification and histoplasmin sensitivity in Canadian eskimos" Canadian Journal of Public Health 57 9:410–418 PMID 5977447 
  19. ^ Anderson, Heather; Honish, Lance; Taylor, Geoff; Johnson, Marcia; Tovstiuk, Chrystyna; Fanning, Anne; Tyrrell, Gregory; Rennie, Robert; Jaipaul, Joy; Sand, Crystal; Probert, Steven 2006 "Histoplasmosis Cluster, Golf Course, Canada" Emerging Infectious Diseases 12 1:163–165 doi:103201/eid1201051083 PMC 3291405  PMID 16494738 
  20. ^ a b c Kauffman, C A 2007 "Histoplasmosis:a Clinical and Laboratory Update" Clinical Microbiology Reviews 20 1:115–132 doi:101128/CMR00027-06 PMC 1797635  PMID 17223625 
  21. ^ Hajjeh, RA 1995 "Disseminated histoplasmosis in persons infected with human immunodeficiency virus" Clinical Infectious Diseases 21 Suppl 1:S108–10 doi:101093/clinids/21supplement_1s108 PMID 8547497 
  22. ^ a b Rippon, John Willard 1988 Medical mycology:the pathogenic fungi and the pathogenic actinomycetes 3rd ed Philadelphia, PA:Saunders ISBN 0721624448 
  23. ^ Waldman, RJ; England, AC; Tauxe, R; Kline, T; Weeks, RJ; Ajello, L; Kaufman, L; Wentworth, B; Fraser, DW 1983 "A winter outbreak of acute histoplasmosis in northern Michigan" American Journal of Epidemiology 117 1:68–75 PMID 6823954 
  24. ^ Leznoff, A; Frank, H; Telner, P; Rosensweig, J; Brandt, JL 1964 "Histoplasmosis in Montreal during the fall of 1963, with observations on erythema multiforme" Canadian Medical Association Journal 91:1154–1160 PMC 1928451  PMID 14226089 
  25. ^ Emmons, CW 1961 "Isolation of Histoplasma capsulatum from soil in Washington, DC" Public Health Reports 76 591–596 
  26. ^ Reid, TM; Schafer, MP 1999 "Direct detection of Histoplasma capsulatum in soil suspensions by two-stage PCR" Molecular and Cellular Probes 13 4:269–273 doi:101006/mcpr19990247 PMID 10441199 
  27. ^ Ajello, L; Weeks, RJ 1983 "Soil decontamination and other control measures" In DiSalvo, Arthur F Occupational mycoses Philadelphia, Pa:Lea and Febiger pp 229–238 ISBN 9780812108859 

External links

histoplasma capsulatum, histoplasma capsulatum images, histoplasma capsulatum infection, histoplasma capsulatum laboratory diagnosis, histoplasma capsulatum microconidia, histoplasma capsulatum morphology, histoplasma capsulatum pneumonia, histoplasma capsulatum symptoms, histoplasma capsulatum transmission, histoplasma capsulatum yeast

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Histoplasma capsulatum

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