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Hibernoma

hibernoma mri, hibernoma pathology
A hibernoma is a benign neoplasm of vestigial brown fat The term was originally used by Gery in 1914

Contents

  • 1 Classification
  • 2 Signs and symptoms
  • 3 Imaging findings
  • 4 Pathology findings
  • 5 Additional images
    • 51 Histochemistry
    • 52 Immunohistochemistry
    • 53 Cytogenetics
    • 54 Cytology
  • 6 Differential diagnoses
  • 7 Management
  • 8 Epidemiology
  • 9 See also
  • 10 References
  • 11 Further reading

Classificationedit

This lesion has been called a fetal lipoma, lipoma of embryonic fat or a lipoma of immature fat1

Signs and symptomsedit

Patients present with a slow-growing, painless, solitary mass, usually of the subcutaneous tissues It is much less frequently noted in the intramuscular tissue It is not uncommon for symptoms to be present for years Benign neoplasm with "BROWN FAT" is noted 12

Imaging findingsedit

In general, imaging studies show a well-defined, heterogeneous mass, usually showing a mass which is hypointense to subcutaneous fat on magnetic resonance T1-weight images Serpentine, thin, low signal bands septations or vessels are often seen throughout the tumor

Pathology findingsedit

From a macroscopic perspective, there is a well-defined, encapsulated or circumscribed mass, showing a soft, yellow tan to deep brown mass The size ranges from 1 to 27 cm, although the mean is about 10 cm1

A high power hematoxylin and eosin stained photograph of a hibernoma

The tumors histologically resemble brown fat There are four histologic types recognized, but one is the most frequently seen typical There is a background of rich vascularity

  1. Lobular type: Variable degrees of differentiation of uniform, round to oval cells with granular eosinophilic cells with prominent borders, alternating with coarsely multivacuolated fat cells pale cells There are usually small centrally placed nuclei without pleomorphism The cells have large cytoplasmic lipid droplets interspersed throughout12
  2. Myxoid variant: Loose, basophilic matrix, with thick fibrous septa, and foamy histiocytes
  3. Lipoma-like variant: Univacuolated lipocytes, with only isolated hibernoma cells
  4. Spindle cell variant: Spindle cell lipoma combined with hibernoma

Additional imagesedit

Histochemistryedit

Oil red O-positive droplets of cytoplasmic lipid can be seen in most cases

Immunohistochemistryedit

The neoplastic cells are S100 protein positive approximately 80%, and show membrane and vacuole CD31 immunoreactivity Uncoupling protein 1 UCP1, a unique brown fat mitochondrial protein, is also positive

Cytogeneticsedit

There are structural rearrangements of 11q13-21, which are considered most characteristic This alteration can be detected by metaphase fluorescent in situ hybridization FISH MEN1 gene 11q131 is most frequently deleted, while GARP gene 11q135 may also be involved

Cytologyedit

The fine needle aspiration smears show small, round, brown fat-like cells, with uniform, small cytoplasmic vacuoles and regular, small, round nuclei There is usually a rich vascular background of branching capillaries It is not uncommon to also have mature fat cells

Differential diagnosesedit

It is important to separate hiberoma from adult rhabdomyoma, a granular cell tumor and a true liposarcoma

Managementedit

Complete surgical excision is the treatment of choice, associated with an excellent long term clinical outcome

Epidemiologyedit

The tumor is rare, affecting adults in the 4th decade most commonly Patients are usually younger than those who present with a lipoma There is a slight male predominance Hibernoma are most commonly identified in the subcutaneous and muscle tissue of the head and neck region shoulders, neck, scapular, followed by thigh, back, chest, abdomen, and arms In rare cases hibernoma may arise in bone tissue, however it is an incidental finding3

See alsoedit

  • Lipoma
  • Skin lesion
  • List of cutaneous conditions

Referencesedit

  1. ^ a b c d Furlong, M A; Fanburg-Smith, J C; Miettinen, M 2001 "The morphologic spectrum of hibernoma: A clinicopathologic study of 170 cases" The American journal of surgical pathology 25 6: 809–814 PMID 11395560 doi:101097/00000478-200106000-00014 
  2. ^ a b Paul, M A; Koomen, A R; Blok, P 1989 "Hibernoma, a brown fat tumour" The Netherlands journal of surgery 41 4: 85–87 PMID 2674772 
  3. ^ Jerman, Anze "Intraosseous hibernoma: case report and tumour characterization" http://wwwbirpublicationsorg/action/showForthcomingTocjournalCode=bjrcr British Institute of Radiology Retrieved 31 August 2015  External link in |website= help

Further readingedit

Lester D R Thompson; Bruce M Wenig 2011 Diagnostic Pathology: Head and Neck: Published by Amirsys Hagerstown, MD: Lippincott Williams & Wilkins pp 8:42–43 ISBN 1-931884-61-7 

hibernoma histology, hibernoma images, hibernoma lipoma, hibernoma molecular, hibernoma mri, hibernoma pathology, hibernoma radiology, hibernoma thigh, hibernoma tumor, hibernomas


Hibernoma Information about

Hibernoma


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    Hibernoma beatiful post thanks!

    29.10.2014


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