Glycopeptide antibioticglycopeptide antibiotics, glycopeptide antibiotic
Glycopeptide antibiotics are a class of drugs of microbial origin that are composed of glycosylated cyclic or polycyclic nonribosomal peptides Significant glycopeptide antibiotics include the anti-infective antibiotics vancomycin, teicoplanin, telavancin, ramoplanin and decaplanin, and the antitumor antibiotic bleomycin Vancomycin is used if infection with methicillin-resistant Staphylococcus aureus MRSA is suspected
- 1 Mechanism
- 2 Use
- 3 History
- 4 Research
- 5 Administration
- 6 References
Some members of this class of drugs inhibit the synthesis of cell walls in susceptible microbes by inhibiting peptidoglycan synthesis They bind to the amino acids within the cell wall preventing the addition of new units to the peptidoglycan In particular, they bind to acyl-D-alanyl-D-alanine in peptidoglycan
Due to their toxicity, use of glycopeptide antibiotics is restricted to patients who are critically ill, who have a demonstrated hypersensitivity to the β-lactams, or who are infected with β-lactam-resistant species These antibiotics are effective principally against Gram-positive cocci They exhibit a narrow spectrum of action, and are bactericidal only against the enterococci Some tissues are not penetrated very well by glycopeptides, and they do not penetrate into the cerebrospinal fluid
Vancomycin was isolated in 1953, and used clinically from 1955 Approved in 1958 by FDA to treat penicillin resistant staphylococci MRSA first seen in 1961 Bleomycin was first discovered in 1966 Teicoplanin was discovered in the early 1990s Telavancin is a semi-synthetic lipoglycopeptide derivative of vancomycin approved by FDA in 2009
While not approved for use in the US, teicoplanin was discovered in the early 1990s and is marketed in Europe It has more fatty acid chains than vancomycin and is considered to be 50 to 100 times more lipophillic Teicoplanin also has an increased half-life compared to vancomycin, as well as having better tissue penetration It can be two to four times more active than vancomycin, but it does depend upon the organism Teicoplanin is more acidic, forming water-soluble salts, so it can be given intramuscularly Teicoplanin is much better at penetrating into leucocytes and phagocytes than vancomycin
Since 2002, isolates of vancomycin-resistant Staphylococcus aureus VRSA have been found in the USA and other countries
Glycopeptides used to be the last effective line of defense for cases of MRSA, however several newer classes of antibiotics have proven to have activity against MRSA, including, in 2000, linezolid of the oxazolidinone class, and in 2003 daptomycin of the lipopeptide class
Several derivatives of vancomycin are currently being developed, including oritavancin and dalbavancin both lipoglycopeptides Possessing longer half-lives than vancomycin, these newer candidates may demonstrate improvements over vancomycin due to less frequent dosing and activity against vancomycin-resistant bacteria
Vancomycin is usually given intravenously, as an infusion, and can cause tissue necrosis and phlebitis at the injection site if given too rapidly Pain at site of injection is indeed a common adverse event One of the side-effects is red man syndrome, an idiosyncratic reaction to bolus caused by histamine release Some other side-effects of vancomycin are nephrotoxicity including renal failure and interstitial nephritis, blood disorders including neutropenia, and deafness, which is reversible once therapy has stopped Over 90% of the dose is excreted in the urine, therefore there is a risk of accumulation in patients with renal impairment, so therapeutic drug monitoring TDM is recommended
Oral preparations of vancomycin are available, however they are not absorbed from the lumen of the gut, so are of no use in treating systemic infections The oral preparations are formulated for the treatment of infections within the gastrointestinal tract, Clostridium difficile, for example
- ^ Loffler CA, Macdougall C, Update on prevalence and treatment of methicillin-resistant Staphylococcus aureus infections, Expert Rev Anti Infect Ther 2007 Dec;56:961-81; http://wwwfuture-drugscom/doi/abs/101586/1478721056961
- ^ Van Bambeke F August 2006 "Glycopeptides and glycodepsipeptides in clinical development: a comparative review of their antibacterial spectrum, pharmacokinetics and clinical efficacy," Curr Opin Investig Drugs 7 8: 740–9 PMID 16955686 http://wwwfacmuclacbe/Full-texts-FACM/Vanbambeke-2006-3pdf
glycopeptide antibiotic, glycopeptide antibiotic list, glycopeptide antibiotics, glycopeptide antibiotics action mechanism, glycopeptide antibiotics examples, glycopeptide antibiotics list, glycopeptide antibiotics mayo clinic, glycopeptide antibiotics moa, glycopeptide antibiotics ppt, glycopeptide antibiotics side effects
Glycopeptide antibiotic Information about
Glycopeptide antibiotic viewing the topic.
There are excerpts from wikipedia on this article and video
Our site has a system which serves search engine function.
You can search all data in our system with above button which written "What did you look for? "
Welcome to our simple, stylish and fast search engine system.
We have prepared this method why you can reach most accurate and most up to date knowladge. The search engine that developed for you transmits you to the latest and exact information with its basic and quick system.
You can find nearly everything data which found from internet with this system.