Glucocorticoids in hippocampal developmentglucocorticoids in hippocampal developmental milestones, glucocorticoids in hippocampal developmental psychology
The hippocampus is an area of the brain integral to learning and memory Removal of this structure can result in the inability to form new memories ie anterograde amnesia as most famously demonstrated in a patient referred to as HM The unique morphology of the hippocampus can be appreciated without the use of special stains and this distinct circuitry has helped further the understanding of neuronal signal potentiation The following will provide an introduction to hippocampal development with particular focus on the role of glucocorticoid signaling
- 1 Hippocampal Development
- 11 Overview
- 12 Principal Cells
- 13 Role of Reelin
- 2 Glucocorticoid Signaling
- 21 Overview
- 22 Adult Hippocampus
- 23 Developing Hippocampus
- 3 References
The hippocampus arises from the medial telencephalon In lower mammals, the hippocampus is located dorsally Considerable expansion of the cerebral cortex in higher mammals eg humans displaces the hippocampus ventrally where it protrudes inferiorly into the lateral ventricles More complete discussion of hippocampal anatomy is found here
Neural progenitors that become hippocampal principal neurons pyramidal and granular cells arise from the ventricular zone of the lateral ventricle In contrast to neural proliferation that leads to cortical formation, hippocampal precursors are produced directly in the ventricular zone because there is no subventricular zone or outer subventricular zone adjacent to the hippocampus Pyramidal CA1 and CA3 precursor cells, therefore, do not have to migrate far to reach their final destination The figure to the right indicates migration of pyramidal neurons forming the CA3 orange and CA1 red cell body layers These cells populate the hippocampus early in development and can be morphologically distinguished from one another in the embryo by 4 months Granular cells populate the hippocampus slightly after pyramidal cell migration These cells have farther distance to travel and follow along the pyramidal cells before entering the hilus; this is represented in the figure as the continuation of migration with the green arrows Granular cell precursors that will populate the dentate gyrus proliferate locally in the hilus This area, also known as the subgranular zone, retains a portion of neurogenic precursors in the adult
Role of Reelin
As in the cortex, it is believed that reelin plays an important role in layering of hippocampal neurons through inhibition of migration Reelin knockout mice lack a single, distinct pyramidal cell body layer due to excess migration Unexpectedly, these mice have reduced migration into dentate gyrus The mechanism of this is involve disruption in radial glial scaffolding
Cortisol is the primary glucocorticoid produced in humans equivalent to rodent corticosterone This steroid hormone is both synthesized and released from the adrenal cortex in response to physical or emotional stress Additionally, basal serum levels of cortisol display circadian variations Cortisol receptors are located throughout the body and are involved in a variety of processes including inflammation and lung maturation
The adult hippocampus is highly enriched in type I mineralocorticoid, MR and type II glucocorticoid, GR glucocorticoid receptors Despite receptor name, cortisol has ten times greater affinity for MRs than GRs At basal GC levels, most MRs are activate Therefore, increasing concentrations of cortisol will preferentially activate GRs The role these receptors play in cognition is discussed elsewhere
Despite having a high level of receptor expression, the physiological role of glucocorticoid signaling in the developing hippocampus is not well defined Animal studies have shown fetal exposure to elevated levels of GCseither by direct corticosterone mimetic injection or stressing of the mother has adverse outcomes In addition to having reduced birth weights, stressed rat pups have a decreased ability to regulate the hypothalamus-pituitary-adrenal axis The hippocampus provides negative feedback to this loop and stressed pups have less sensitive glucocorticoid signaling resulting in elevated levels of glucocorticoids basally and an exaggerated response during stress As adults, these rats can have impaired cognitive function Understanding the role of glucocorticoid exposure is important; mothers at risk of preterm delivery are commonly given dexamethasone, a GR agonist, to accelerate fetal lung development and reduce morbidity associated with prematurity These animals studies have found that postnatal care to prenatally stressed animals can reverse the adverse effects of glucocorticoid signaling More research is needed to understand the role of glucocorticoids in the context of human hippocampal development
- ^ a b c d Purves, Dale; et al 2008 Neuroscience Fourth Edition Sunderland, MA: Sinauer Associates ISBN 978-0-87893-697-7
- ^ a b c d e f g h i Anderson, Peter; et al 2007 The Hippocampus Book New York, New York: Oxford University Press ISBN 978-0-19-510027-3
- ^ a b Sanes, Dan; et al 2006 Development of the Nervous System 2nd Edition Burlington, MA: Elsevier Inc ISBN 978-0-12-618621-5
- ^ Rennert, Nancy "Cortisol Level" Medline Plus ADAM, Inc Retrieved 28 February 2014
- ^ a b Seckl, JR; Meaney, MJ Dec 2004 "Glucocorticoid programming" Annals of the New York Academy of Sciences 1032: 63–84 doi:101196/annals1314006 PMID 15677396
- ^ Lee, Men-Jean; et al "Antenatal corticosteroid therapy for reduction of neonatal morbidity and mortality from preterm delivery" UpToDate Retrieved 28 February 2014
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