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Fred Hutchinson Cancer Research Center

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The Fred Hutchinson Cancer Research Center, also known as Fred Hutch or The Hutch, is a cancer research institute established in 1972 in Seattle, Washington23

Contents

  • 1 History
  • 2 Notable faculty
  • 3 Commercialization
  • 4 Campus
  • 5 References
  • 6 External links

Historyedit

The center grew out of the Pacific Northwest Research Foundation, founded in 1956 by Dr William B Hutchinson 1909–1997 The Foundation was dedicated to the study of heart surgery, cancer, and diseases of the endocrine system Hutchinson's younger brother Fred 1919–1964, was a major league pitcher and manager who died of lung cancer at age 45 The next year, he established the Fred Hutchinson Cancer Research Center as a division of the Pacific Northwest Research Foundation2

With the help of Senator Warren G Magnuson in 1972, PNRF received federal funding under the National Cancer Act of 1971 to create in Seattle one of the 15 new NCI-designated Cancer Centers aimed at conducting basic research4 called for under 1971 Act; the Fred Hutchinson Cancer Research Center became independent 1972 and its building opened three years later in 197525678:3,5

The center was named an NCI-designated Comprehensive Cancer Center in 19769

In 1998, the center formed the Seattle Cancer Care Alliance SCCA, a separate nonprofit corporation,10 with UW Medicine, and Seattle Children's This solidified the center's reach into clinical care and was essential for it retaining its NCI comprehensive center designation;11 the designation was extended to the center's consortium including the SCCA in 20039 SCCA's outpatient clinic first opened in January 200111

In 2001, The Seattle Times published a series of articles alleging that investigators at the center including the Center's co-founder Dr E Donnall Thomas were conducting unethical clinical studies on cancer patients The paper alleged that in two cancer studies conducted in the 1980s and early 1990s, patients were not informed about all the risks of the study, nor about the study doctors' financial interest in study outcome The paper also alleged that this financial interest may have contributed to the doctors' failure to halt the studies despite evidence that patients were dying sooner and more frequently than expected12 In response, the center formed a panel of independent experts to review its existing research practices, leading to adoption of "one of the nation's toughest conflict-of-interest rules"13

In 2014, the center announced that D Gary Gilliland would become president and CEO in 2015;14 he took over from Lawrence Corey who was appointed as the 4th President in 2010, following the retirement of Lee Hartwell15

Notable facultyedit

The center has employed three recipients of the Nobel Prize in physiology or medicine:

  • Linda Buck, PhD, who received the award in 2004 for solving many details of the olfactory system;16 and
  • E Donnall Thomas, MD, who received the award in 1990 for his pioneering work in bone-marrow transplantation and who died in 2012;1718 and
  • Lee Hartwell, PhD, who received the honor in 2001 for his discoveries regarding the mechanisms that control cell division19 After retiring from leading the center in 2010, Hartwell left to join Arizona State University20

Commercializationedit

The center is active in technology transfer In 2013, it was one of the top ten biomedical research institutions in the field excluding universities; it made 18 new deals with companies to develop inventions made at the center, and earned $10,684,882 in income from past deals it had signed21 Most notably, Juno Therapeutics, a company developing CAR-T immunotherapy for cancer and that raised $314 million in venture capital investments and had a $265 million initial public offering in 2014, was started based on inventions made at the center22 As of 2015, about twenty companies had been started based on center inventions since 1975, including Immunex and Icos22

Campusedit

The institute's main campus consists of thirteen buildings on fifteen acres 61 ha in the South Lake Union neighborhood of Seattle23

In 1987, the center began exploring possible new homes to replace its 9-building campus on First Hill that it was set to outgrow2425 A site in the South Lake Union neighborhood, envisioned by the city as a future high-tech and biotechnology hub,26 was chosen in September 1988 after a deal to move to Fremont fell through earlier that year2728 The first phase of the campus, designed by firm Zimmer Gunsul Frasca Partnership,29 began construction in 1991 and opened on June 1, 1993 in a ceremony that included the burying of a time capsule set to open in 20933031

The campus is accessible via the Mercer Street exit of Interstate 5 as well as several public transportation routes, including the South Lake Union Streetcar, and the city's bikeshare system, Pronto Cycle Share32

Referencesedit

  1. ^ "Financial Summary 2014" Fred Hutchinson Cancer Research Center 2014 Retrieved June 27, 2015 
  2. ^ "Mission Statement" Fred Hutchinson Cancer Research Center Retrieved August 6, 2009 
  3. ^ Simone JV Understanding cancer centers J Clin Oncol 2002 Dec 1;2023:4503-7 PMID 12454105
  4. ^ "Center dedication Friday" Spokane Daily Chronicle Washington Associated Press September 2, 1975 p 6 
  5. ^ Jane Sanders for the University of Washington Libraries 1987 Essay: A Legacy of Public Service
  6. ^ Melissa Allison for the Seattle Times October 20, 2012 Obituary: E Donnall Thomas, Nobel winner for bone-marrow transplant advances
  7. ^ US Government Accounting Office March 17, 1976 Comprehensive Cancer Centers: Their Locations and Role
  8. ^ a b NCI Fred Hutchinson/University of Washington Cancer Consortium Page access June 27, 2015
  9. ^ Washington State Hospital Association Hospital Details: Seattle Cancer Care Alliance Page accessed June 27, 2015
  10. ^ a b BusinessWire October 24, 2012 Fitch Affirms Seattle Cancer Care Alliance WA Rev Bonds at A+; Outlook Stable
  11. ^ "Uninformed Consent" The Seattle Times 2001 
  12. ^ Doughton, Sandi August 4, 2009 "Hutch leader Lee Hartwell guided center's ride to top, will retire next June" The Seattle Times 
  13. ^ Seattle Times Staff November 20, 2014 Genetics expert named director, president of Fred Hutch
  14. ^ "Lawrence Corey, infectious disease expert, new Hutchinson Center President" Seattle Post-Intelligencer July 29, 2010 Retrieved July 4, 2011 
  15. ^ "Medicine 2004" nobelprizeorg Retrieved March 29, 2009 
  16. ^ Frederick R Appelbaum Perspective: E Donnall Thomas 1920–2012 Science 3386111:1163, November 30, 2012
  17. ^ "Medicine 1990" nobelprizeorg Retrieved March 29, 2009 
  18. ^ "Medicine 2001" nobelprizeorg Retrieved March 29, 2009 
  19. ^ Luke Timmerman for Xconomy September 20, 2010 Lee Hartwell, at 70, Tackles Personalized Medicine, Education in Latest Career Phase
  20. ^ Brady Huggett Top US universities and institutes for life sciences in 2013 Nature Biotechnology 3211:1085
  21. ^ a b Annie Zak for the Puget Sound Business Journal, February 13, 2015 Fred Hutch and its amazing spinoff machine
  22. ^ "Our Sustainable Campus" Fred Hutchinson Cancer Research Center Retrieved December 17, 2015 
  23. ^ Balter, Joni September 27, 1987 "Growing Fred Hutchinson Cancer Center may move" The Seattle Times p A1 Retrieved December 17, 2015 – via NewsBank Subscription required help 
  24. ^ Levy, Nat December 17, 2015 "Why and how the Hutch moved to SLU" Seattle Daily Journal of Commerce Retrieved December 17, 2015 
  25. ^ Lilly, Dick June 20, 1993 "Firms Moving Quicker than Commons Plan" The Seattle Times p B1 Retrieved December 17, 2015 – via NewsBank Subscription required help 
  26. ^ Angelos, Constantine September 30, 1988 "Hutchinson Center approves new site - Board OK's plan to buy Lake Union" The Seattle Times p A1 Retrieved December 17, 2015 – via NewsBank Subscription required help 
  27. ^ Nogaki, Sylvia June 25, 1988 "Hutchinson Division's move canceled - Grants make N end site too small" The Seattle Times p A10 Retrieved December 17, 2015 – via NewsBank Subscription required help 
  28. ^ King, Marsha July 28, 1991 "In This Space At This Time -- ZGF's Organic Style Gives Birth To Buildings That Fit" The Seattle Times Retrieved December 17, 2015 
  29. ^ Woodward, Kristen February 2015 "40 things you didn't know about Fred Hutch" Hutch Magazine Fred Hutchinson Cancer Research Center Retrieved December 17, 2015 
  30. ^ "Hutchinson Dedicates a New Lab Building" The Seattle Times June 2, 1993 p B2 
  31. ^ Campus Buildings & Destinations PDF Map Fred Hutchinson Cancer Research Center Retrieved December 17, 2015 

External linksedit

  • Fred Hutchinson Cancer Research Center Web site

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    29.10.2014


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