Thu . 18 Nov 2018


4W4O, 4X4M, 4ZNE

Identifiers Aliases FCGR1A, CD64, CD64A, FCRI, IGFR1, Fc fragment of IgG receptor Ia External IDs MGI: 95498 HomoloGene: 475 GeneCards: FCGR1A
Gene location Human
Chr Chromosome 1 human
Band 1q212 Start 149,782,671 bp
End 149,792,518 bp
RNA expression pattern

More reference expression data
Orthologs Species Human Mouse Entrez
RefSeq mRNA



RefSeq protein



Location UCSC Chr 1: 14978 – 14979 Mb Chr 3: 9628 – 9629 Mb PubMed search Wikidata
^ "Mouse PubMed Reference:" 
  • ^ Maresco DL, Chang E, Theil KS, Francke U, Anderson CL September 1996 "The three genes of the human FCGR1 gene family encoding Fc gamma RI flank the centromere of chromosome 1 at 1p12 and 1q21" Cytogenetics and Cell Genetics 73 3: 157–63 doi:101159/000134330 PMID 8697799 
  • ^ Maresco DL, Blue LE, Culley LL, Kimberly RP, Anderson CL, Theil KS November 1998 "Localization of FCGR1 encoding Fcgamma receptor class I in primates: molecular evidence for two pericentric inversions during the evolution of human chromosome 1" Cytogenetics and Cell Genetics 82 1-2: 71–4 doi:101159/000015067 PMID 9763663 
  • ^ "Entrez Gene: FCGR1A Fc fragment of IgG, high affinity Ia, receptor CD64" 
  • ^ Morton HC, van den Herik-Oudijk IE, Vossebeld P, Snijders A, Verhoeven AJ, Capel PJ, van de Winkel JG Dec 1995 "Functional association between the human myeloid immunoglobulin A Fc receptor CD89 and FcR gamma chain Molecular basis for CD89/FcR gamma chain association" The Journal of Biological Chemistry 270 50: 29781–7 doi:101074/jbc2705029781 PMID 8530370 
  • ^ The function of Fcγ receptors in dendritic cells and macrophages Martin Guilliams Pierre Bruhns Yvan Saeys Hamida Hammad and Bart N Lambrecht FEBRUARY 2014 | VOLUME 14 Nature Reviews Immunology
  • Further reading

    • Monteiro RC, Van De Winkel JG 2003 "IgA Fc receptors" Annual Review of Immunology 21: 177–204 doi:101146/annurevimmunol21120601141011 PMID 12524384 
    • Ernst LK, van de Winkel JG, Chiu IM, Anderson CL Aug 1992 "Three genes for the human high affinity Fc receptor for IgG Fc gamma RI encode four distinct transcription products" The Journal of Biological Chemistry 267 22: 15692–700 PMID 1379234 
    • Benech PD, Sastry K, Iyer RR, Eichbaum QG, Raveh DP, Ezekowitz RA Oct 1992 "Definition of interferon gamma-response elements in a novel human Fc gamma receptor gene Fc gamma RIb and characterization of the gene structure" The Journal of Experimental Medicine 176 4: 1115–23 doi:101084/jem17641115 PMC 2119393  PMID 1402657 
    • Porges AJ, Redecha PB, Doebele R, Pan LC, Salmon JE, Kimberly RP Nov 1992 "Novel Fc gamma receptor I family gene products in human mononuclear cells" The Journal of Clinical Investigation 90 5: 2102–9 doi:101172/JCI116094 PMC 443278  PMID 1430234 
    • van de Winkel JG, Ernst LK, Anderson CL, Chiu IM Jul 1991 "Gene organization of the human high affinity receptor for IgG, Fc gamma RI CD64 Characterization and evidence for a second gene" The Journal of Biological Chemistry 266 20: 13449–55 PMID 1830050 
    • Eizuru Y, Minamishima Y 1989 "Induction of Fc IgG receptors by simian cytomegaloviruses in human embryonic lung fibroblasts" Intervirology 29 6: 339–45 doi:101159/000150065 PMID 2852656 
    • Allen JM, Seed B Jan 1989 "Isolation and expression of functional high-affinity Fc receptor complementary DNAs" Science 243 4889: 378–81 doi:101126/science2911749 PMID 2911749 
    • Allen JM, Seed B Dec 1988 "Nucleotide sequence of three cDNAs for the human high affinity Fc receptor FcRI" Nucleic Acids Research 16 24: 11824 doi:101093/nar/162411824 PMC 339124  PMID 2974947 
    • Indik ZK, Hunter S, Huang MM, Pan XQ, Chien P, Kelly C, Levinson AI, Kimberly RP, Schreiber AD Jul 1994 "The high affinity Fc gamma receptor CD64 induces phagocytosis in the absence of its cytoplasmic domain: the gamma subunit of Fc gamma RIIIA imparts phagocytic function to Fc gamma RI" Experimental Hematology 22 7: 599–606 PMID 7516890 
    • Valerius T, Repp R, de Wit TP, Berthold S, Platzer E, Kalden JR, Gramatzki M, van de Winkel JG Aug 1993 "Involvement of the high-affinity receptor for IgG Fc gamma RI; CD64 in enhanced tumor cell cytotoxicity of neutrophils during granulocyte colony-stimulating factor therapy" Blood 82 3: 931–9 PMID 7687898 
    • Wang AV, Scholl PR, Geha RS Sep 1994 "Physical and functional association of the high affinity immunoglobulin G receptor Fc gamma RI with the kinases Hck and Lyn" The Journal of Experimental Medicine 180 3: 1165–70 doi:101084/jem18031165 PMC 2191633  PMID 8064233 
    • Takai S, Kasama M, Yamada K, Kai N, Hirayama N, Namiki H, Taniyama T Jan 1994 "Human high-affinity Fc gamma RI CD64 gene mapped to chromosome 1q212-q213 by fluorescence in situ hybridization" Human Genetics 93 1: 13–5 doi:101007/BF00218905 PMID 8270248 
    • Morton HC, van den Herik-Oudijk IE, Vossebeld P, Snijders A, Verhoeven AJ, Capel PJ, van de Winkel JG Dec 1995 "Functional association between the human myeloid immunoglobulin A Fc receptor CD89 and FcR gamma chain Molecular basis for CD89/FcR gamma chain association" The Journal of Biological Chemistry 270 50: 29781–7 doi:101074/jbc2705029781 PMID 8530370 
    • De SK, Venkateshan CN, Seth P, Gajdusek DC, Gibbs CJ Mar 1998 "Adenovirus-mediated human immunodeficiency virus-1 Nef expression in human monocytes/macrophages and effect of Nef on downmodulation of Fcgamma receptors and expression of monokines" Blood 91 6: 2108–17 PMID 9490697 
    • Kyono WT, de Jong R, Park RK, Liu Y, Heisterkamp N, Groffen J, Durden DL Nov 1998 "Differential interaction of Crkl with Cbl or C3G, Hef-1, and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG Fc gamma RI" Journal of Immunology 161 10: 5555–63 PMID 9820532 
    • Fanger NA, Cosman D, Peterson L, Braddy SC, Maliszewski CR, Borges L Nov 1998 "The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes" European Journal of Immunology 28 11: 3423–34 doi:101002/SICI1521-414119981128:11<3423::AID-IMMU3423>30CO;2-2 PMID 9842885 
    • Gorgani NN, Altin JG, Parish CR Aug 1999 "Histidine-rich glycoprotein regulates the binding of monomeric IgG and immune complexes to monocytes" International Immunology 11 8: 1275–82 doi:101093/intimm/1181275 PMID 10421785 
    • Tridandapani S, Lyden TW, Smith JL, Carter JE, Coggeshall KM, Anderson CL Jul 2000 "The adapter protein LAT enhances fcgamma receptor-mediated signal transduction in myeloid cells" The Journal of Biological Chemistry 275 27: 20480–7 doi:101074/jbcM909462199 PMID 10781611 


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