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Estratetraenol


Estratetraenol, also known as estra-1,3,510,16-tetraen-3-ol, is an endogenous steroid found in women that has been described as having pheromone-like activities in primates, including humans Estratetraenol is synthesized from androstadienone by aromatase likely in the ovaries, and is related to the estrogen sex hormones, yet has no known estrogenic effects It was first identified from the urine of pregnant women

Estratetraenyl acetate, or estra-1,3,510,16-tetraen-3-yl acetate, is a more potent synthetic derivative of estratetraenol

Estratetraenol is an estrane C18 steroid and an analogue of estradiol where the C17β hydroxyl group has been removed and a double bond has been formed between the C16 and C17 positions

See also

  • List of neurosteroids § Pheromones and pherines

References

  1. ^ Thysen, B; Elliott, WH; Katzman, PA 1968 "Identification of estra-1,3,510,16-tetraen-3-ol estratetraenol from the urine of pregnant women 1" Steroids 11 1: 73–87 doi:101016/S0039-128X6880052-2 PMID 4295975 
  2. ^ Laska, M; Wieser, A; Salazar, LT 2006 "Sex-specific differences in olfactory sensitivity for putative human pheromones in nonhuman primates" Journal of Comparative Psychology 120 2: 106–12 doi:101037/0735-70361202106 PMID 16719588 
  3. ^ Jacob, S; Hayreh, DJ; McClintock, MK 2001 "Context-dependent effects of steroid chemosignals on human physiology and mood" Physiology & Behavior 74 1–2: 15–27 doi:101016/S0031-93840100537-6 PMID 11564447 
  4. ^ Savic, I; Berglund, H; Gulyas, B; Roland, P 2001 "Smelling of odorous sex hormone-like compounds causes sex-differentiated hypothalamic activations in humans" Neuron 31 4: 661–8 doi:101016/S0896-62730100390-7 PMID 11545724 
  5. ^ Berglund, H; Lindström, P; Savic, I 2006 "Brain response to putative pheromones in lesbian women" Proceedings of the National Academy of Sciences of the United States of America 103 21: 8269–74 doi:101073/pnas0600331103 PMC 1570103  PMID 16705035 
  6. ^ Berglund, H; Lindström, P; Dhejne-Helmy, C; Savic, I 2008 "Male-to-female transsexuals show sex-atypical hypothalamus activation when smelling odorous steroids" Cerebral cortex New York, NY : 1991 18 8: 1900–8 doi:101093/cercor/bhm216 PMID 18056697 
  7. ^ Joseph Johannes; Agnes Maria Weusten 1989 Biochemical pathways in human testicular steroidogenesis PDF Pressa Trajectina 
  8. ^ Thysen B, Elliott WH, Katzman PA 1968 "Identification of estra-1,3,510,16-tetraen-3-ol estratetraenol from the urine of pregnant women 1" Steroids 11 1: 73–87 doi:101016/s0039-128x6880052-2 PMID 4295975 
  9. ^ Lundström 2005 Human pheromones : psychological and neurological modulation of a putative human pheromone Uppsala: Acta Universitatis Upsaliensis p 17 ISBN 91-554-6297-9 





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