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Epietiocholanolone


Epietiocholanolone, also known as 5β-androstan-3β-ol-17-one or as etiocholan-3β-ol-17-one, is an etiocholane 5β-androstane steroid as well as an inactive metabolite of testosterone that is formed in the liver The metabolic pathway is testosterone to 5β-dihydrotestosterone via 5β-reductase, 5β-dihydrotestosterone to 3β,5β-androstanediol via 3β-hydroxysteroid dehydrogenase, and 3β,5β-androstanediol to epietiocholanolone via 17β-hydroxysteroid dehydrogenase Epietiocholanolone can also be formed directly from 5β-androstanedione via 3β-hydroxysteroid dehydrogenase It is glucuronidated and sulfated in the liver and excreted in urine

See also

  • Androsterone
  • Epiandrosterone
  • Etiocholanolone

References

  1. ^ a b Arun Nagrath; Narendra Malhotra; Seth Shikha 31 July 2012 Progress in Obstetrics & Gynecology JP Medical Ltd pp 265– ISBN 978-93-5025-779-1 
  2. ^ J Horsky; J Presl 6 December 2012 Ovarian Function and its Disorders: Diagnosis and Therapy Springer Science & Business Media pp 107– ISBN 978-94-009-8195-9 
  3. ^ a b c d MORFIN Robert 20 December 2010 Les stéroïdes naturels de A à Z Lavoisier pp 428– ISBN 978-2-7430-1918-1 
  4. ^ Hugh L J Makin; DB Gower 4 June 2010 Steroid Analysis Springer Science & Business Media pp 462– ISBN 978-1-4020-9775-1 
  5. ^ Hauser B, Deschner T, Boesch C 2008 "Development of a liquid chromatography-tandem mass spectrometry method for the determination of 23 endogenous steroids in small quantities of primate urine" J Chromatogr B 862 1-2: 100–12 doi:101016/jjchromb200711009 PMID 18054529 




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