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Eosinophilic fasciitis

eosinophilic fasciitis, eosinophilic fasciitis mayo clinic
Eosinophilic fasciitis /ˌiːəˌsɪnəˈfɪlɪk ˌfæʃiˈaɪtᵻs, ˌiːoʊ-, -ˌfæsi-/12, also known as "Shulman's syndrome",3 is a form of fasciitis, the inflammatory diseases that affect the fascia, the connective tissues surrounding muscles, blood vessels and nerves Unlike other diseases in that category, it is limited to the arms and legs, and usually resolves itself, although some cases require corticosteroids, and some cases are associated with aplastic anemia4

The presentation of eosinophilic fasciitis is similar to scleroderma or systemic sclerosis However, unlike scleroderma, it affects the fascia, not the skin dermis The characteristic and severe effects of scleroderma and systemic sclerosis, such as Raynaud's syndrome, involvement of the extremities, prominent small blood vessels telangiectasia, and visceral changes such as swallowing problems, are absent

It was first characterized in 1974,5 and it is not yet known whether it is actually a distinct condition or just a different presentation However, it remains used for diagnostic purposes

Several cases have been reported after strenuous exercise


  • 1 Symptoms
  • 2 Cause
  • 3 Diagnosis
  • 4 Treatment
  • 5 Epidemiology
  • 6 See also
  • 7 References
  • 8 Further reading
  • 9 External links


As it is a rare disease, a clear set of symptoms is difficult to define Usually, patients show severe pain and swelling is reported but clinical presentations vary It can have an 'orange peel' like appearance6 Less common features are joint pain and carpal tunnel syndrome



The key to diagnosis is skin changes combined with blood eosinophilia but the most accurate test is a skin, fascia and muscle biopsy


Common treatments include corticosteroids7 such as prednisone, though other medications such as hydroxychloroquine8 have also been used The prognosis is usually good in the case of an early treatment if there is no visceral involvement69


Typical age of onset is around 40 to 50 years It is not clear whether it is more common in women than men - patient numbers are small and some studies report a preponderance of men and others women10 It is also found in children

See alsoedit

  • Eosinophilia
  • List of cutaneous conditions


  1. ^ "Eosinophilic" Oxford Dictionaries Oxford University Press Retrieved 2016-01-21  "fasciitis" Oxford Dictionaries Oxford University Press Retrieved 2016-01-21 
  2. ^ "Eosinophilic" Merriam-Webster Dictionary Retrieved 2016-01-21  "fasciitis" Merriam-Webster Dictionary Retrieved 2016-01-21 
  3. ^ Rapini, Ronald P; Bolognia, Jean L; Jorizzo, Joseph L 2007 Dermatology: 2-Volume Set St Louis: Mosby ISBN 1-4160-2999-0 
  4. ^ Merck Manual, Professional Edition, Eosinophilic Fasciitis
  5. ^ Shulman LE 1975 "Diffuse fasciitis with eosinophilia: a new syndrome" Trans Assoc Am Physicians 88: 70–86 PMID 1224441 
  6. ^ a b Bischoff, Lindsay; Chris T Derk January 2008 "Eosinophilic fasciitis: demographics, disease pattern and response to treatment: report of 12 cases and review of the literature" International Journal of Dermatology 47 1: 29–35 PMID 18173597 doi:101111/j1365-4632200703544x 
  7. ^ Antic M, Lautenschlager S, Itin PH 2006 "Eosinophilic fasciitis 30 years after - what do we really know Report of 11 patients and review of the literature" Dermatology Basel 213 2: 93–101 PMID 16902285 doi:101159/000093847 
  8. ^ Lakhanpal S, Ginsburg WW, Michet CJ, Doyle JA, Moore SB 1988 "Eosinophilic fasciitis: clinical spectrum and therapeutic response in 52 cases" Semin Arthritis Rheum 17 4: 221–31 PMID 3232080 doi:101016/0049-01728890008-X 
  9. ^ Valadares, Diana; Joao Neves; Isabel Almeida; Carlos Lopes; Carlos Vasconcelos February 2011 "Iron Lady: A Case of Eosinophilic Fasciitis" Journal of Medical Case Reports 2: 34–36 doi:104021/jmc118w 
  10. ^ Wojas-Pelc A, Wielowieyska-Szybińska D, Lipko-Godlewska S 2004 "Eosinophilic fasciitis--current database" Pol Merkur Lekarski in Polish 16 96: 585–8 PMID 15510903 

Further readingedit

  • Lakhanpal, Sharad; Ginsburg, William W; Michet, Clement J; Doyle, John A; Moore, SBreanndan 1988 "Eosinophilic fasciitis: Clinical spectrum and therapeutic response in 52 cases" Seminars in Arthritis and Rheumatism 17 4: 221–231 ISSN 0049-0172 PMID 3232080 doi:101016/0049-01728890008-X 
  • Barnes L, Rodnan GP, Medsger TA, Short D August 1979 "Eosinophilic fasciitis A pathologic study of twenty cases" The American Journal of Pathology 96 2: 493–518 PMC 2042453  PMID 474708  |access-date= requires |url= help
  • Doyle JA, Ginsburg WW September 1989 "Eosinophilic fasciitis" The Medical Clinics of North America 73 5: 1157–66 PMID 2671538 
  • Michet CJ, Doyle JA, Ginsburg WW January 1981 "Eosinophilic fasciitis: report of 15 cases" Mayo Clinic Proceedings Mayo Clinic 56 1: 27–34 PMID 7453247 
  • Bennett, R M; Herron, A; Keogh, L 1977 "Eosinophilic fasciitis Case report and review of the literature" Annals of the Rheumatic Diseases 36 4: 354–359 ISSN 0003-4967 doi:101136/ard364354 
  • Falanga, Vincent; Medsger, Thomas A 1987 "Frequency, levels, and significance of blood eosinophilia in systemic sclerosis, localized scleroderma, and eosinophilic fasciitis" Journal of the American Academy of Dermatology 17 4: 648–656 ISSN 0190-9622 doi:101016/S0190-96228770251-5 
  • Varga J, Kähäri VM November 1997 "Eosinophilia-myalgia syndrome, eosinophilic fasciitis, and related fibrosing disorders" Current Opinion in Rheumatology 9 6: 562–70 PMID 9375286 doi:101097/00002281-199711000-00013 
  • Kent, Lawrence T; Cramer, Stewart F; Moskowitz, Roland W 1981 "Eosinophilic fasciitis" Arthritis & Rheumatism 24 5: 677–683 ISSN 0004-3591 doi:101002/art1780240508 
  • Moulton SJ, Kransdorf MJ, Ginsburg WW, Abril A, Persellin S March 2005 "Eosinophilic fasciitis: spectrum of MRI findings" AJR American journal of roentgenology 184 3: 975–8 PMID 15728627 doi:102214/ajr184301840975 Retrieved 2012-08-30 

External linksedit

  • Merck Manual, Professional Edition, Eosinophilic Fasciitis
  • DermAtlas 1973850164
  • synd/2773 at Who Named It

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