Sun . 19 Jun 2019

Dirithromycin

dirithromycin enteric coated tablets, dirithromycin
Dirithromycin is a macrolide glycopeptide antibiotic

Dirithromycin Dynabac is a more lipid-soluble prodrug derivative of 9S-erythromycyclamine prepared by condensation of the latter with 2-2-methoxyethoxyacetaldehyde The 9N, 11O-oxazine ring thus formed is a hemi-aminal that is unstable under both acidic and alkaline aqueous conditions and undergoes spontaneous hydrolysis to form erythromycyclamine Erythromycyclamine is a semisynthetic derivative of erythromycin in which the 9-ketogroup of the erythronolide ring has been converted to an amino group Erythromycyclamine retains the antibacterial properties of erythromycin oral administration The prodrug, dirithromycin, is provided as enteric coated tablets to protect it from acid catalyzed hydrolysis in the stomach Orally administered dirithromycin is absorbed rapidly into the plasma, largely from the small intestine Spontaneous hydrolysis to erythromycyclamine occurs in the plasma Oral bioavailability is estimated to be about 10%, but food does not affect absorption of the prodrug

Discontinuation

Dirithromycin is no longer available in the United States Since the production of dirithromycin is discontinued in the US, National Institutes of Health recommend that people taking dirithromycin should consult their physicians to discuss switching to another treatment However, dirithromycin is still available in many European countries

References

  1. ^ "Dynabac Drug Details" US Food and Drug Administration Retrieved 2007-05-25 
  2. ^ "Dirithromycin" MedlinePlus US National Library of Medicine January 1, 2006 Archived from the original on 2007-03-29 Retrieved 2007-05-25 

dirithromycin, dirithromycin discontinued, dirithromycin enteric, dirithromycin enteric coated tablets, dirithromycin enteric-coated capsules, dirithromycin impurity, dirithromycin side effects


Dirithromycin Information about

Dirithromycin


  • user icon

    Dirithromycin beatiful post thanks!

    29.10.2014


Dirithromycin
Dirithromycin
Dirithromycin viewing the topic.
Dirithromycin what, Dirithromycin who, Dirithromycin explanation

There are excerpts from wikipedia on this article and video

Random Posts

Modern philosophy

Modern philosophy

Modern philosophy is a branch of philosophy that originated in Western Europe in the 17th century, a...
Tim Shadbolt

Tim Shadbolt

Timothy Richard "Tim" Shadbolt born 19 February 1947 is a New Zealand politician He is the Mayor of ...
HK Express

HK Express

Andrew Cowen Deputy CEO Website wwwhkexpresscom HK Express Traditional Chinese 香港快運航空...
List of shrinking cities in the United States

List of shrinking cities in the United States

The following municipalities in the United States have lost at least 20% of their population, from a...