Dirithromycindirithromycin enteric coated tablets, dirithromycin
Dirithromycin is a macrolide glycopeptide antibiotic
Dirithromycin Dynabac is a more lipid-soluble prodrug derivative of 9S-erythromycyclamine prepared by condensation of the latter with 2-2-methoxyethoxyacetaldehyde The 9N, 11O-oxazine ring thus formed is a hemi-aminal that is unstable under both acidic and alkaline aqueous conditions and undergoes spontaneous hydrolysis to form erythromycyclamine Erythromycyclamine is a semisynthetic derivative of erythromycin in which the 9-ketogroup of the erythronolide ring has been converted to an amino group Erythromycyclamine retains the antibacterial properties of erythromycin oral administration The prodrug, dirithromycin, is provided as enteric coated tablets to protect it from acid catalyzed hydrolysis in the stomach Orally administered dirithromycin is absorbed rapidly into the plasma, largely from the small intestine Spontaneous hydrolysis to erythromycyclamine occurs in the plasma Oral bioavailability is estimated to be about 10%, but food does not affect absorption of the prodrug
Dirithromycin is no longer available in the United States Since the production of dirithromycin is discontinued in the US, National Institutes of Health recommend that people taking dirithromycin should consult their physicians to discuss switching to another treatment However, dirithromycin is still available in many European countries
- ^ "Dynabac Drug Details" US Food and Drug Administration Retrieved 2007-05-25
- ^ "Dirithromycin" MedlinePlus US National Library of Medicine January 1, 2006 Archived from the original on 2007-03-29 Retrieved 2007-05-25
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