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dihydrostreptomycin sulfate, dihydrostreptomycin
Dihydrostreptomycin is a derivative of streptomycin that has a bactericidal property It's a semisynthetic aminoglycoside antibiotic used in the treatment of tuberculosis

It acts by irreversibly binding the S12 protein in the bacterial 30S ribosomal subunit, after being actively transported across the cell membrane, which interferes with the initiation complex between the mRNA and the bacterial ribosome This leads to the synthesis of defective non-functional proteins, which results in the bacterial cell's death

It causes ototoxicity, which is why it is no longer used in humans

See also

  • Streptomycin
  • Translation biology


  1. ^ a b "Dihydrostreptomycin Code C61724 - NCI Thesaurus" Retrieved July 7, 2016 
  2. ^ "Dihydrostreptomycin Sulfate - MeSH - NCBI" Retrieved July 7, 2016 
  3. ^ Harrison, Wiley H 1954 "Ototoxicity of dihydrostreptomycin" Quarterly bulletin Northwestern University Evanston, Ill Medical School 28 3: 271–3 PMC 3803976  PMID 13186082 

External links

  • Dihydrostreptomycin | C21H41N7O12 - PubChem

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