Tue . 19 Apr 2019

D-alanine—D-alanine ligase

d alanine d alanine ligase enzyme, d alanine d alanine ligase function
In enzymology, a D-alanine—D-alanine ligase EC 6324 is an enzyme that catalyzes the chemical reaction

ATP + 2 D-alanine ⇌ ADP + phosphate + D-alanyl-D-alanine

Thus, the two substrates of this enzyme are ATP and D-alanine, whereas its 3 products are ADP, phosphate, and D-alanyl-D-alanine

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases peptide synthases The systematic name of this enzyme class is D-alanine:D-alanine ligase ADP-forming Other names in common use include alanine:alanine ligase ADP-forming, and alanylalanine synthetase This enzyme participates in d-alanine metabolism and peptidoglycan biosynthesis Phosphinate and D-cycloserine are known to inhibit this enzyme

The N-terminal region of the D-alanine—D-alanine ligase is thought to be involved in substrate binding, while the C-terminus is thought to be a catalytic domain

Structural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 1EHI, 1IOV, 1IOW, 2DLN, 2FB9, 2I80, 2I87, and 2I8C


  1. ^ Roper DI, Huyton T, Vagin A, Dodson G August 2000 "The molecular basis of vancomycin resistance in clinically relevant Enterococci: crystal structure of D-alanyl-D-lactate ligase VanA" Proc Natl Acad Sci USA 97 16: 8921–5 doi:101073/pnas150116497 PMC 16797  PMID 10908650 

Further reading

  • Ito, E; Strominger JL 1962 "Enzymatic synthesis of the peptide in bacterial uridine nucleotides II Enzymatic synthesis and addition of D-alanyl-D-alanine" J Biol Chem 237: 2696–2703 
  • Neuhaus FC 1962 "Kinetic studies on D-Ala-D-Ala synthetase" Fed Proc 21: 229 
  • van Heijenoort J 2001 "Recent advances in the formation of the bacterial peptidoglycan monomer unit" Nat Prod Rep 18 5: 503–19 doi:101039/a804532a PMID 11699883 

This article incorporates text from the public domain Pfam and InterPro IPR011127

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d alanine d alanine ligase chain, d alanine d alanine ligase enzyme, d alanine d alanine ligase function, d alanine d alanine ligase reaction

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D-alanine—D-alanine ligase

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