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Cornelia Bargmann

cornelia bargmann, cornelia bargmann rockefeller
Cornelia Isabella "Cori" Bargmann born 1961[2] is an American neurobiologist She is known for her work on the genetic and neural circuit mechanisms of behavior using C elegans, particularly the mechanisms of olfaction in the worm She has been elected to the National Academy of Sciences and had been a Howard Hughes Medical Institute investigator at UCSF and then Rockefeller University from 1995 to 2016 It was announced on September 21, 2016 that she had been named the incoming president of science at the Chan Zuckerberg Initiative, effective October 1, 2016 In 2012 she was awarded the $1 million Kavli Prize, and in 2013 the $3 million Breakthrough Prize in Life Sciences

Contents

  • 1 Biography
  • 2 Notable papers
  • 3 Awards
  • 4 References
    • 41 Footnotes
    • 42 Sources

Biography

Bargmann was born in Virginia and grew up in Athens, Georgia, one of four children, and the daughter of Rolf Bargmann, a statistician and computer scientist at the University of Georgia[3]

She completed undergraduate studies at the University of Georgia in 1981, with a degree in biochemistry She completed graduate school from MIT with a PhD in the department of Biology in 1987 in the lab of Robert Weinberg She examined the molecular mechanisms of oncogenesis, and helped identify the role of Ras in bladder cancer She also did significant work on neu, an oncogene that later lead to significant treatments in breast cancer[4]

Bargmann then completed a postdoc with H Robert Horvitz at MIT, working on molecular biology mechanisms of neuroscience She began working on chemosensory behavior in C elegans, and achieved several breakthroughs, demonstrating, among other things, that nematodes have a sense of smell[4]

Bargmann accepted a faculty position at UCSF in 1991 She continued her studies of worm behavior and neural control, focusing on olfaction at the molecular level She looked for genes similar to those found by Richard Axel and Linda Buck to be the basis of smell and taste, and found those genes in the recently sequenced genome of C elegans Her work led to discoveries of the mechanisms underlying complex behaviors, such as feeding behaviors[4] The work has continued to lead to a deeper understanding of the brain, sensory abilities, and neuronal development Bargmann also identified SYG-1, a "matchmaker" molecule—a molecule that directs neurons to form connections with each other during development[5][6]

In 2004, Bargmann moved to Rockefeller University[5] She served as an Investigator of the Howard Hughes Medical Institute until 2016 before she took the President of CZI Bargmann’s lab uses a relatively simple organism, the nematode C elegans, and its extremely sensitive sense of smell to study how genes regulate neuronal development, function, and behavior Her work has been recognized with numerous awards including election to the National Academy of Sciences

Bargmann is married to fellow olfactory scientist Richard Axel, a Nobel laureate Previously, she had been married to Michael J Finney, who also completed graduate studies at MIT and is now a Director at Sage Science, Inc

For a vivid portrait of Bargmann as a young scientist working in Weinberg's lab, see Natalie Angier's "Natural Obsessions: The Search for the Oncogene"

Bargmann was featured in the New York Times on June 21, 2011

Notable papers

  • Shen, Kang; Bargmann, Cornelia I March 7, 2003 "The immunoglobin superfamily protein SYG-1 determines the location of specific synapses in C Elegans" Cell 112 5: 619–630 doi:101016/S0092-86740300113-2 PMID 12628183  [3][7]
  • de Bono, Mario; Bargmann, Cornelia I September 4, 1998 "Natural variation in a neuropeptide Y receptor homolog modifies social behavior and food response in C Elegans" Cell 94 5: 679–689 doi:101016/S0092-86740081609-8 PMID 9741632 
  • Troemel, ER, Kimmel, BE, and Bargmann, CI 1997 Reprogramming chemotaxis responses: sensory neurons define olfactory preferences in C elegans Cell 91, 161-169
  • Zhang, Y, Lu, H, and Bargmann, CI 2005 Pathogenic bacteria induce aversive olfactory learning in Caenorhabditis elegans Nature 438, 179-184
  • Chalasani, SH, Chronis, N, Tsunozaki, M, Gray, JM, Ramot, D, Goodman, MB, and Bargmann, CI 2007 Dissecting a circuit for olfactory behaviour in Caenorhabditis elegans Nature 450, 63-70
  • Chalasani, SH, Kato, S, Albrecht, DR, Nakagawa, T, Abbott, LF, and Bargmann, CI 2010 Neuropeptide feedback modifies odor-evoked dynamics in Caenorhabditis elegans Nature Neuroscience 6, 615-621

Awards

  • Lucille P Markey Award 1990–1995[8]
  • Searle Scholar Award 1992–1995[9]
  • Taskago Prize for olfaction research 1997[10]
  • W Alden Spencer Award for neuroscience research 1997[11]
  • Charles Judson Herick Award for comparative neurology 2000[12]
  • Fellow of the American Academy of Arts and Sciences 2002[2]
  • Member of the National Academy of Sciences 2003
  • Dargut and Milena Kemali Prize for Basic and Clinical Neuroscience 2004[13]
  • Richard Lounsbery Award 2009
  • Kavli Prize in neuroscience 2012
  • Member of the American Philosophical Society 2012
  • Breakthrough Prize in Life Sciences 2013 for the genetics of neural circuits and behavior, and synaptic guidepost molecules

References

Footnotes

  1. ^ The Kavli Prize: "Cornelia Bargmann" Archived 2013-12-03 at the Wayback Machine
  2. ^ a b "Book of Members, 1780-2010: Chapter B" PDF American Academy of Arts and Sciences Retrieved May 17, 2011 
  3. ^ a b Crevar
  4. ^ a b c Marino
  5. ^ a b Rockefeller, Jan 5, 2004
  6. ^ Friend, 2003
  7. ^ UCSF description of paper
  8. ^ https://wwwncbinlmnihgov/pmc/articles/PMC552904/
  9. ^ https://wwwncbinlmnihgov/pmc/articles/PMC552904/
  10. ^ https://wwwaibsorg/public-policy-reports/2008/10/27/nas-announces-chtml
  11. ^ https://wwwaibsorg/public-policy-reports/2008/10/27/nas-announces-chtml
  12. ^ https://wwwaibsorg/public-policy-reports/2008/10/27/nas-announces-chtml
  13. ^ https://wwwaibsorg/public-policy-reports/2008/10/27/nas-announces-chtml

Sources

  • Natalie Angier, "Natural Obsessions: The Search for the Oncogene"
  • Alex Crevar, "As the Worm Turns", Georgia Magazine, 2004 discussing Cynthia Kenyon and Bargmann
  • Tim Friend, "Nerve cell mystery is unlocked", USA Today, March 10, 2003 available online at USAtodaycom explaining the 2003 matchmaker Cell paper
  • Karen Hopkin, "I Smell a Worm", The Scientist, v19, n15, p 52 Aug 1, 2005
  • Melissa Marino, "Biography of Cornelia I Bargmann", PNAS, v102, n9 March 1, 2005 available at PNAS
  • HHMI, HHMI Cori Bargmann profile
  • HHMI, "Genetic Analysis of Olfactory Behavior and Neural Development"
  • The Rockefeller University, "Internationally renowned neurobiologist to join Rockefeller University; Cori Bargmann discovered 'matchmaker' molecule", Jan 5, 2004
  • Searle, Searle Scholar profile of Cori Bargmann
  • UCSF, "First molecule discovered that directs nerve cells to connect with each other", March 6, 2003
  • Nicholas Wade, "In Tiny Worm, Unlocking Secrets of the Brain", New York Times, June 20, 2011
  • http://wwwbusinessinsidercom/coolest-women-in-science-2015-7External links
  • Melissa Marino "Biography of Cori Bargmann",2005
  • Bargmann lab
  • Cori Bargmann's Seminar: "Genes, the Brain and Behavior"
  • Bargmann CI Author Profile Page on Pubget
  • Announcement of Chan Zuckerberg Initiative role

cornelia bargmann, cornelia bargmann rockefeller, cornelia i. bargmann, cornelia isabella bargmann


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