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Cogan syndrome

cogan syndrome symptoms, cogan syndrome and hearing loss
Cogan syndrome is a rare disorder characterized by recurrent inflammation of the front of the eye the cornea and often fever, fatigue, and weight loss, episodes of dizziness, and hearing loss It can lead to deafness or blindness if untreated The classic form of the disease was first described by DG Cogan in 1945


  • 1 Signs and symptoms
  • 2 Causes
  • 3 Diagnosis
  • 4 Treatment
  • 5 History
  • 6 References
  • 7 Further reading

Signs and symptomsedit

Cogan's syndrome is a rare, rheumatic disease characterized by inflammation of the ears and eyes Cogan's syndrome can lead to vision difficulty, hearing loss and dizziness The condition may also be associated with blood-vessel inflammation called vasculitis in other areas of the body that can cause major organ damage in 15% of those afflicted or, in a small number of cases, even death It most commonly occurs in a person's 20s or 30s The cause is not known However, one theory is that it is an autoimmune disorder in which the body's immune system mistakenly attacks tissue in the eye and ear1


It is currently thought that Cogan's syndrome is an autoimmune disease The inflammation in the eye and ear are due to the patient's own immune system producing antibodies that attack the inner ear and eye tissue Autoantibodies can be demonstrated in the blood of some patients, and these antibodies have been shown to attack inner ear tissue in laboratory studies Infection with the bacteria Chlamydia pneumoniae has been demonstrated in some patients prior to the development of Cogan's syndrome, leading some researchers to hypothesize that the autoimmune disease may be initiated by the infection C pneumoniae is a common cause of mild pneumonia, and the vast majority of patients who are infected with the bacteria do not develop Cogan's syndrome2


While the white blood cell count, erythrocyte sedimentation rate, and C-reactive protein tests may be abnormal and there may be abnormally high levels of platelets in the blood or too few red blood cells in the blood, none of these findings is a reliable indicator of the disease A slit-lamp examination is essential Recent work has suggested that high-resolution MRI and antibodies to inner ear antigens may be helpful Cogan syndrome can occur in children, and is particularly difficult to recognize in that situation3


For more severe disease, oral corticosteroids may be necessary to reduce the inflammatory response When large amounts of steroids are required or if the disease is severe and is not responding to steroid therapy, other immunosuppressive medications often are recommended These immunosuppressive drugs include methotrexate, cyclophosphamide, cyclosporine or azathioprine In some cases, combinations of these medicines are prescribed Occasionally, if the disease has damaged blood vessels, cochlear implantation may need to be done to correct the problem

Cinnarizine is mainly used to treat nausea and vomiting associated with motion sickness, vertigo, Ménière's disease, or Cogan's syndrome4 Studies have shown it to produce significant improvement in hearing loss in some patients5


In 1945, the ophthalmologist David Glendenning Cogan 1908–1993 first described the "nonsyphilitic interstitial keratitis and vestibuloauditory symptoms" that would later bear his name6 In 1963, the atypical form of Cogan syndrome, also known as "Logan Syndrome" was first described7


  1. ^ "Cogan's Syndrome" Retrieved 2008-11-06 
  2. ^ Timothy C Hain "Cogan's Syndrome" Archived from the original on May 17, 2008 Retrieved 2008-11-06 
  3. ^ Timothy C Hain "Cogan's syndrome" Retrieved 2008-11-06 
  4. ^ "Cogan's Syndrome - Treatment" Retrieved 2008-11-06 
  5. ^ Timothy C Hain: Cogan's Syndrome at the American Hearing Research Foundation, Chicago, Illinois 2008
  6. ^ Cogan, David G 1945 "Syndrome of Nonsyphilitic Interstitial Keratitis and Vestibuloauditory Symptoms" Archives of Ophthalmology 33 2: 144–9 doi:101001/archopht194500890140064007 
  7. ^ Bennett FM April 1963 "Bilateral recurrent episcleritis associated with posterior corneal changes, vestibulo-auditory symptoms and rheumatoid arthritis" American Journal of Ophthalmology 55: 815–8 PMID 13967466 doi:101016/0002-93946392451-6 

Further readingedit

  • Haynes BF, Kaiser-Kupfer MI, Mason P, Fauci AS November 1980 "Cogan syndrome: studies in thirteen patients, long-term follow-up, and a review of the literature" Medicine 59 6: 426–41 PMID 6969345 doi:101097/00005792-198011000-00003 
  • Gluth MB, Baratz KH, Matteson EL, Driscoll CL April 2006 "Cogan syndrome: a retrospective review of 60 patients throughout a half century" Mayo Clinic Proceedings 81 4: 483–8 PMID 16610568 doi:104065/814483 
  • Norton EW, Cogan DG May 1959 "Syndrome of nonsyphilitic interstitial keratitis and vestibuloauditory symptoms; a long-term follow-up" AMA Archives of Ophthalmology 61 5: 695–7 PMID 13636563 doi:101001/archopht195900940090697004 
  • Bicknell JM, Holland JV March 1978 "Neurologic manifestations of Cogan syndrome" Neurology 28 3: 278–81 PMID 305011 doi:101212/wnl283278 
  • Casselman JW, Majoor MH, Albers FW January 1994 "MR of the inner ear in patients with Cogan syndrome" American Journal of Neuroradiology 15 1: 131–8 PMID 8141044 
  • Allen NB, Cox CC, Cobo M, et al March 1990 "Use of immunosuppressive agents in the treatment of severe ocular and vascular manifestations of Cogan's syndrome" The American Journal of Medicine 88 3: 296–301 PMID 2309745 doi:101016/0002-93439090157-9 
  • Kundell SP, Ochs HD July 1980 "Cogan syndrome in childhood" The Journal of Pediatrics 97 1: 96–8 PMID 7381656 doi:101016/s0022-34768080142-9 

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