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Clear-cell sarcoma of the kidney


Clear cell sarcoma of the kidney CCSK is an extremely rare type of kidney cancer comprising 3% of all pediatric renal tumours1 Clear cell sarcoma of the kidney can spread from the kidney to other organs, most commonly the bone, but also including the lungs, brain, and soft tissues of the body

Despite the similarities in names, clear cell sarcoma of the kidney is unrelated to clear cell sarcoma of soft tissue, also known as malignant melanoma of soft parts2

Contents

  • 1 Signs and symptoms
  • 2 Cause and epidemiology
  • 3 Treatment
  • 4 External links

Signs and symptomsedit

Typical gross features include large size mean diameter 113 cm, a mucoid texture, foci of necrosis, and prominent cyst formation3

Cause and epidemiologyedit

Research in 2005 showed that CCSK can arise within a renal mesenchymal cell that shows a wide variety of neural markers4 Typical presentation is between 1 and 4 years of age, and a 2:1 male-to-female ratio is observed5

Treatmentedit

2004 research showed that CCSK patients exhibit an improved relapse-free survival from a longer course of therapy when using vincristine, doxorubicin, and dactinomycin, but their long-term survival is unchanged compared with patients receiving 6 months of therapy6

  1. ^ Sharma SC, Menon PA, Clear cell sarcoma of the kidney, Journal of Postgraduate Medicine, 2001, vol 47, p 206, jpgmonlinecom PMID 11832627 Accessed 2012-5-21
  2. ^ Poppe B, Forsyth R, Dhaene K, Speleman F, Soft tissue tumors: Clear cell sarcoma, Atlas Genet Cytogenet Oncol Haematol, November 2002
  3. ^ Argani, Pedram MD; Perlman, Elizabeth J MD; Breslow, Norman E PhD; Browning, Nancy G MS; Green, Daniel M MD; D'Angio, Giulio J MD; Beckwith, J Bruce MD, Clear Cell Sarcoma of the Kidney: A Review of 351 Cases From the National Wilms Tumor Study Group Pathology Center, American Journal of Surgical Pathology, Jan 2000, 241, p 4, journalslwwcom Accessed 2012-5-21
  4. ^ Cutcliffe C, Kersey D, Huang CC, Zeng Y, Walterhouse D, Perlman EJ, Clear Cell Sarcoma of the Kidney: Up-regulation of Neural Markers with Activation of the Sonic Hedgehog and Akt Pathways, Clinical Cancer Research, Nov 15 2005, 1122, pp 7986-94, clincancerresaacrjournalsorg doi:101158/1078-0432CCR-05-1354, PMID 16299227 Accessed 2012-5-21
  5. ^ Seibel N, Clear Cell Sarcoma of the Kidney, Medscape Reference, Updated 2014-2-11, Accessed 2014-5-18
  6. ^ Effect of Duration of Treatment on Treatment Outcome for Patients With Clear-Cell Sarcoma of the Kidney: A Report From the National Wilms' Tumor Study Group, Journal of Clinical Oncology, Feb 1 2004, vol 223, pp 468-473, jcoascopubsorg doi:101200/JCO200406058 Accessed 2012-5-21

Kidney Treatment And Solutions

External linksedit

  • Clear cell sarcoma of the kidney entry in the public domain NCI Dictionary of Cancer Terms

 This article incorporates public domain material from the US National Cancer Institute document "Dictionary of Cancer Terms"


Clear-cell sarcoma of the kidney Information about

Clear-cell sarcoma of the kidney


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    Clear-cell sarcoma of the kidney beatiful post thanks!

    29.10.2014


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