Mon . 20 Jul 2020
TR | RU | UK | KK | BE |

Chromosome 10

chromosome 10 genes, chromosome 10 abnormalities
Chromosome 10 is one of the 23 pairs of chromosomes in humans People normally have two copies of this chromosome Chromosome 10 spans about 133 million base pairs the building material of DNA and represents between 4 and 45 percent of the total DNA in cells

Contents

  • 1 Genes
    • 11 Number of genes
    • 12 Gene list
  • 2 Diseases and disorders
  • 3 Cytogenetic band
  • 4 References
  • 5 External links

Genes

Number of genes

The following are some of the gene count estimates of human chromosome 10 Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies for technical details, see gene prediction Among various projects, the collaborative consensus coding sequence project CCDS takes an extremely conservative strategy So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes[5]

Estimated by Protein-coding genes Non-coding RNA genes Pseudogenes Source Release date
CCDS 706 - - [2] 2016-09-08
HGNC 708 244 614 [6] 2017-05-12
Ensembl 728 881 568 [7] 2017-03-29
UniProt 750 - - [8] 2018-02-28
NCBI 754 842 654 [9][10][11] 2017-05-19

Gene list

See also: Category:Genes on human chromosome 10

The following is a partial list of genes on human chromosome 10 For complete list, see the link in the infobox on the right

  • AFAP1L2: actin filament associated protein 1 like 2
  • ALL1 encoding protein Leukemia, acute lymphocytic, susceptibility to, 1
  • ALOX5: Arachidonate 5-Lipoxygenase processes essential fatty acids to leukotrienes, which are important agents in the inflammatory response; also facilitates development and maintenance of cancer stem cells, slow-dividing cells thought to give rise to a variety of cancers, including leukemia
  • ARHGAP21: rho GTPase activating protein 21
  • ARID5B: encoding protein AT-rich interactive domain-containing protein 5B
  • AS3MT: encoding enzyme Arsenite methyltransferase
  • AVPI1: encoding protein Arginine vasopressin-induced protein 1
  • C10orf118: encoding protein Uncharacterized protein C10orf118
  • C10orf67: chromosome 10 open reading frame 67
  • C10orf76: chromosome 10 open reading frame 76
  • C10orf99: encoding protein Chromosome 10 open reading frame 99
  • CAMK1D: calcium/calmodulin-dependent protein kinase ID
  • CCAR1: Cell division cycle and apoptosis regulator 1
  • CCDC3: Coiled-coil domain-containing protein 3
  • CCNY: Cyclin-Y
  • CDC123: Cell division cycle protein 123 homolog
  • CDH23: cadherin-like 23
  • CDNF: cerebral dopamine neurotrophic factor
  • COMMD3-BMI1: COMMD3-BMI1 readthrough
  • CUTC: Copper homeostasis protein cutC homolog
  • CXCL12: chemokine C-X-C motif ligand 12, SDF-1, scyb12
  • DDX50: DExD-box helicase 50
  • DEPP: decidual protein induced by progesterone
  • DHX32: DEAH-box helicase 32
  • DNAJC12: DnaJ Hsp40 homolog, subfamily c, member 12
  • DNAJC9: DnaJ Hsp40 homolog, subfamily c, member 9
  • DPYSL4: Dihydropyrimidinase-related protein 4
  • EBLN1: encoding protein Endogenous Bornavirus-like nucleoprotein 1
  • ECD: ecdysoneless cell cycle regulator
  • EGR2: early growth response 2 Krox-20 homolog, Drosophila
  • EIF5AP1: eukaryotic translation initiation factor 5A-like 1
  • EPC1: Enhancer of polycomb homolog 1
  • ERCC6: excision repair cross-complementing rodent repair deficiency, complementation group 6
  • FAM107B: family with sequence similarity 107, member B
  • FAM13C: family with sequence similarity 13, member C
  • FAM170B: encoding protein Family with sequence similarity 170 member B
  • FAM188A: family with sequence similarity 188, member A
  • FAM213A: family with sequence similarity 213, member A
  • FAM25BP encoding protein Protein FAM25
  • FAS-AS1, long non-coding RNA
  • FGFR2: fibroblast growth factor receptor 2 bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson–Weiss syndrome
  • FRA10AC1: Fragile site, folic acid type
  • FRAT1: WNT signaling pathway regulator
  • FRAT2: WNT signaling pathway regulator
  • FRMPD2 encoding protein FERM and PDZ domain containing 2
  • GATA3: encoding the GATA3 transcription factor GATA3 is critical for the embryonic development of the parathyroid gland, neural component of hearing, and kidney Haploinsufficiency of the gene underlies a rare disorder, the hypoparathyrodism, deafness, and renal dysplasia syndrome
  • GHITM: growth hormone-inducible transmembrane protein
  • GPRIN2: G protein-regulated inducer of neurite outgrowth 2
  • GTPBP4: Nucleolar GTP-binding protein 4
  • HELLS: Lymphoid-specific helicase
  • HKDC1: hexokinase domain containing 1
  • KIN: DNA/RNA-binding protein KIN17
  • MTG1: mitochondrial GTPase 1
  • NPM3: nucleoplasmin-3
  • NRBF2: nuclear receptor-binding factor 2
  • NSMCE4A: non-SMC element 4 homolog A
  • OTUD1: encoding protein OTU deubiquitinase 1
  • PCBD1: 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha TCF1
  • PCDH15: protocadherin 15
  • PI4K2A: phosphatidylinositol 4-kinase 2-alpha
  • PIP4K2A: phosphatidylinositol 5 phosphate 4-kinase type-2 alpha
  • PITRM1: pitrilysin metallopeptidase 1
  • PLEKHS1 encoding protein Pleckstrin homology domain containing S1
  • PLXDC2: plexin domain-containing protein 2
  • PROSER2: proline and serine rich 2 or c10orf47
  • PTEN gene: phosphatase and tensin homolog mutated in multiple advanced cancers 1
  • RET: ret proto-oncogene multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease
  • RPP30: ribonuclease P protein subunit p30
  • RRP12: ribosomal RNA processing 12 homolog
  • RSU1: ras suppressor protein 1
  • SGPL1: sphingosine-1-phosphate lyase 1
  • SMNDC1: survival motor neuron domain containing 1
  • SPG9 encoding protein Spastic paraplegia 9 autosomal dominant
  • SRGN: serglycin
  • STAMBPL1: STAM binding protein like 1
  • STOX1: encoding protein Storkhead box 1
  • SUPV3L1: Suv3 like RNA helicase
  • TACC2 encoding protein Transforming acidic coiled-coil-containing protein 2
  • TBC1D12: TBC1 domain family, member 12
  • TCTN3: tectonic family member 3
  • TMEM10: opalin
  • TMEM26: encoding protein Transmembrane protein 26
  • UCN3: urocortin-3
  • UROS: uroporphyrinogen III synthase congenital erythropoietic porphyria
  • USP6NL: USP6 N-terminal like protein
  • UTF1: undifferentiated embryonic cell transcription factor 1
  • WASHC2C: WASH complex subunit 2C
  • WBP1L: WW domain binding protein 1-like
  • ZNF37A: zinc finger protein 37A
  • ZNF438: zinc finger protein 438

Diseases and disorders

The following diseases are related to genes on chromosome 10:

  • Apert syndrome
  • Beare–Stevenson cutis gyrata syndrome
  • Charcot–Marie–Tooth disease
  • Cockayne syndrome
  • congenital erythropoietic porphyria
  • Cowden syndrome
  • Crouzon syndrome
  • Glioblastoma Multiforme
  • Hermansky–Pudlak syndrome
  • Hirschprung disease
  • Jackson–Weiss syndrome
  • multiple endocrine neoplasia type 2
  • nonsyndromic deafness
  • Pfeiffer syndrome
  • porphyria
  • tetrahydrobiopterin deficiency
  • Thiel–Behnke corneal dystrophy
  • Usher syndrome
  • Wolman syndrome

Cytogenetic band

G-banding ideograms of human chromosome 10G-banding ideogram of human chromosome 10 in resolution 850 bphs Band length in this diagram is proportional to base-pair length This type of ideogram is generally used in genome browsers eg Ensembl, UCSC Genome BrowserG-banding patterns of human chromosome 10 in three different resolutions 400,[12] 550[13] and 850[4] Band length in this diagram is based on the ideograms from ISCN 2013[14] This type of ideogram represents actual relative band length observed under a microscope at the different moments during the mitotic process[15] G-bands of human chromosome 10 in resolution 850 bphs[16]
Chr Arm[17] Band[18] ISCN
start[19]
ISCN
stop[19]
Basepair
start
Basepair
stop
Stain[20] Density
10 p 153 0 229 7000100000000000000♠1 7006300000000000000♠3,000,000 gneg
10 p 152 229 329 7006300000100000000♠3,000,001 7006380000000000000♠3,800,000 gpos 25
10 p 151 329 630 7006380000100000000♠3,800,001 7006660000000000000♠6,600,000 gneg
10 p 14 630 917 7006660000100000000♠6,600,001 7007122000000000000♠12,200,000 gpos 75
10 p 13 917 1175 7007122000010000000♠12,200,001 7007173000000000000♠17,300,000 gneg
10 p 1233 1175 1361 7007173000010000000♠17,300,001 7007183000000000000♠18,300,000 gpos 75
10 p 1232 1361 1432 7007183000010000000♠18,300,001 7007184000000000000♠18,400,000 gneg
10 p 1231 1432 1604 7007184000010000000♠18,400,001 7007223000000000000♠22,300,000 gpos 75
10 p 122 1604 1662 7007223000010000000♠22,300,001 7007243000000000000♠24,300,000 gneg
10 p 121 1662 1891 7007243000010000000♠24,300,001 7007293000000000000♠29,300,000 gpos 50
10 p 1123 1891 2063 7007293000010000000♠29,300,001 7007311000000000000♠31,100,000 gneg
10 p 1122 2063 2235 7007311000010000000♠31,100,001 7007342000000000000♠34,200,000 gpos 25
10 p 1121 2235 2406 7007342000010000000♠34,200,001 7007380000000000000♠38,000,000 gneg
10 p 111 2406 2621 7007380000010000000♠38,000,001 7007398000000000000♠39,800,000 acen
10 q 111 2621 2850 7007398000010000000♠39,800,001 7007416000000000000♠41,600,000 acen
10 q 1121 2850 3051 7007416000010000000♠41,600,001 7007455000000000000♠45,500,000 gneg
10 q 1122 3051 3252 7007455000010000000♠45,500,001 7007486000000000000♠48,600,000 gpos 25
10 q 1123 3252 3409 7007486000010000000♠48,600,001 7007511000000000000♠51,100,000 gneg
10 q 211 3409 3753 7007511000010000000♠51,100,001 7007594000000000000♠59,400,000 gpos 100
10 q 212 3753 3839 7007594000010000000♠59,400,001 7007628000000000000♠62,800,000 gneg
10 q 213 3839 4097 7007628000010000000♠62,800,001 7007688000000000000♠68,800,000 gpos 100
10 q 221 4097 4469 7007688000010000000♠68,800,001 7007731000000000000♠73,100,000 gneg
10 q 222 4469 4655 7007731000010000000♠73,100,001 7007759000000000000♠75,900,000 gpos 50
10 q 223 4655 4970 7007759000010000000♠75,900,001 7007803000000000000♠80,300,000 gneg
10 q 231 4970 5200 7007803000010000000♠80,300,001 7007861000000000000♠86,100,000 gpos 100
10 q 232 5200 5331 7007861000010000000♠86,100,001 7007877000000000000♠87,700,000 gneg
10 q 2331 5331 5558 7007877000010000000♠87,700,001 7007911000000000000♠91,100,000 gpos 75
10 q 2332 5558 5672 7007911000010000000♠91,100,001 7007923000000000000♠92,300,000 gneg
10 q 2333 5672 5887 7007923000010000000♠92,300,001 7007953000000000000♠95,300,000 gpos 50
10 q 241 5887 5973 7007953000010000000♠95,300,001 7007975000000000000♠97,500,000 gneg
10 q 242 5973 6131 7007975000010000000♠97,500,001 7008100100000000000♠100,100,000 gpos 50
10 q 2431 6131 6202 7008100100001000000♠100,100,001 7008101200000000000♠101,200,000 gneg
10 q 2432 6202 6317 7008101200001000000♠101,200,001 7008103100000000000♠103,100,000 gpos 25
10 q 2433 6317 6374 7008103100001000000♠103,100,001 7008104000000000000♠104,000,000 gneg
10 q 251 6374 6646 7008104000001000000♠104,000,001 7008110100000000000♠110,100,000 gpos 100
10 q 252 6646 6761 7008110100001000000♠110,100,001 7008113100000000000♠113,100,000 gneg
10 q 253 6761 6890 7008113100001000000♠113,100,001 7008117300000000000♠117,300,000 gpos 75
10 q 2611 6890 7090 7008117300001000000♠117,300,001 7008119900000000000♠119,900,000 gneg
10 q 2612 7090 7219 7008119900001000000♠119,900,001 7008121400000000000♠121,400,000 gpos 50
10 q 2613 7219 7506 7008121400001000000♠121,400,001 7008125700000000000♠125,700,000 gneg
10 q 262 7506 7721 7008125700001000000♠125,700,001 7008128800000000000♠128,800,000 gpos 50
10 q 263 7721 8050 7008128800001000000♠128,800,001 7008133797422000000♠133,797,422 gneg

References

  1. ^ "Human Genome Assembly GRCh38 - Genome Reference Consortium" National Center for Biotechnology Information 2013-12-24 Retrieved 2017-03-04 
  2. ^ a b "Search results - 10[CHR] AND "Homo sapiens"[Organism] AND "has ccds"[Properties] AND alive[prop] - Gene" NCBI CCDS Release 20 for Homo sapiens 2016-09-08 Retrieved 2017-05-28 
  3. ^ Tom Strachan; Andrew Read 2 April 2010 Human Molecular Genetics Garland Science p 45 ISBN 978-1-136-84407-2 
  4. ^ a b Genome Decoration Page, NCBI Ideogram data for Homo sapience 850 bphs, Assembly GRCh38p3 Last update 2014-06-03 Retrieved 2017-04-26
  5. ^ Pertea M, Salzberg SL 2010 "Between a chicken and a grape: estimating the number of human genes" Genome Biol 11 5: 206 doi:101186/gb-2010-11-5-206 PMC 2898077  PMID 20441615 
  6. ^ "Statistics & Downloads for chromosome 10" HUGO Gene Nomenclature Committee 2017-05-12 Retrieved 2017-05-19 
  7. ^ "Chromosome 10: Chromosome summary - Homo sapiens" Ensembl Release 88 2017-03-29 Retrieved 2017-05-19 
  8. ^ "Human chromosome 10: entries, gene names and cross-references to MIM" UniProt 2018-02-28 Retrieved 2018-03-16 
  9. ^ "Search results - 10[CHR] AND "Homo sapiens"[Organism] AND "genetype protein coding"[Properties] AND alive[prop] - Gene" NCBI 2017-05-19 Retrieved 2017-05-20 
  10. ^ "Search results - 10[CHR] AND "Homo sapiens"[Organism] AND "genetype miscrna"[Properties] OR "genetype ncrna"[Properties] OR "genetype rrna"[Properties] OR "genetype trna"[Properties] OR "genetype scrna"[Properties] OR "genetype snrna"[Properties] OR "genetype snorna"[Properties] NOT "genetype protein coding"[Properties] AND alive[prop] - Gene" NCBI 2017-05-19 Retrieved 2017-05-20 
  11. ^ "Search results - 10[CHR] AND "Homo sapiens"[Organism] AND "genetype pseudo"[Properties] AND alive[prop] - Gene" NCBI 2017-05-19 Retrieved 2017-05-20 
  12. ^ Genome Decoration Page, NCBI Ideogram data for Homo sapience 400 bphs, Assembly GRCh38p3 Last update 2014-03-04 Retrieved 2017-04-26
  13. ^ Genome Decoration Page, NCBI Ideogram data for Homo sapience 550 bphs, Assembly GRCh38p3 Last update 2015-08-11 Retrieved 2017-04-26
  14. ^ International Standing Committee on Human Cytogenetic Nomenclature 2013 ISCN 2013: An International System for Human Cytogenetic Nomenclature 2013 Karger Medical and Scientific Publishers ISBN 978-3-318-02253-7 
  15. ^ Sethakulvichai, W; Manitpornsut, S; Wiboonrat, M; Lilakiatsakun, W; Assawamakin, A; Tongsima, S 2012 "Estimation of band level resolutions of human chromosome images" PDF In Computer Science and Software Engineering JCSSE, 2012 International Joint Conference on: 276–282 doi:101109/JCSSE20126261965 
  16. ^ Genome Decoration Page, NCBI Ideogram data for Homo sapience 850 bphs, Assembly GRCh38p3 Last update 2014-06-03 Retrieved 2017-04-26
  17. ^ "p": Short arm; "q": Long arm
  18. ^ For cytogenetic banding nomenclature, see article locus
  19. ^ a b These values ISCN start/stop are based on the length of bands/ideograms from the ISCN book, An International System for Human Cytogenetic Nomenclature 2013 Arbitrary unit
  20. ^ gpos: Region which is positively stained by G banding, generally AT-rich and gene poor; gneg: Region which is negatively stained by G banding, generally CG-rich and gene rich; acen Centromere var: Variable region; stalk: Stalk
  • Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L, Steward CA, Sims SK, Jones MC, Searle S, Scott C, Howe K, Hunt SE, Andrews TD, Gilbert JG, Swarbreck D, Ashurst JL, Taylor A, Battles J, Bird CP, Ainscough R, Almeida JP, Ashwell RI, Ambrose KD, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Bates K, Beasley H, Bray-Allen S, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Cahill P, Camire D, Carter NP, Chapman JC, Clark SY, Clarke G, Clee CM, Clegg S, Corby N, Coulson A, Dhami P, Dutta I, Dunn M, Faulkner L, Frankish A, Frankland JA, Garner P, Garnett J, Gribble S, Griffiths C, Grocock R, Gustafson E, Hammond S, Harley JL, Hart E, Heath PD, Ho TP, Hopkins B, Horne J, Howden PJ, Huckle E, Hynds C, Johnson C, Johnson D, Kana A, Kay M, Kimberley AM, Kershaw JK, Kokkinaki M, Laird GK, Lawlor S, Lee HM, Leongamornlert DA, Laird G, Lloyd C, Lloyd DM, Loveland J, Lovell J, McLaren S, McLay KE, McMurray A, Mashreghi-Mohammadi M, Matthews L, Milne S, Nickerson T, Nguyen M, Overton-Larty E, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter K, Rice CM, Rogosin A, Ross MT, Sarafidou T, Sehra HK, Shownkeen R, Skuce CD, Smith M, Standring L, Sycamore N, Tester J, Thorpe A, Torcasso W, Tracey A, Tromans A, Tsolas J, Wall M, Walsh J, Wang H, Weinstock K, West AP, Willey DL, Whitehead SL, Wilming L, Wray PW, Young L, Chen Y, Lovering RC, Moschonas NK, Siebert R, Fechtel K, Bentley D, Durbin R, Hubbard T, Doucette-Stamm L, Beck S, Smith DR, Rogers J 2004 "The DNA sequence and comparative analysis of human chromosome 10" Nature 429 6990: 375–81 doi:101038/nature02462 PMID 15164054 
  • Deloukas P, French L, Meitinger T, Moschonas NK 2000 "Report of the third international workshop on human chromosome 10 mapping and sequencing 1999" Cytogenet Cell Genet 90 1–2: 1–12 doi:101159/000015653 PMID 11060438 
  • Gilbert F 2001 "Chromosome 10" Genet Test 5 1: 69–82 doi:101089/109065701750168824 PMID 11336406 

External links

  • National Institutes of Health "Chromosome 10" Genetics Home Reference Retrieved 2017-05-06 
  • "Chromosome 10" Human Genome Project Information Archive 1990–2003 Retrieved 2017-05-06 

chromosome 10, chromosome 10 abnormalities, chromosome 10 disorder symptoms, chromosome 10 disorders, chromosome 10 duplication, chromosome 10 genes, chromosome 10 microdeletion, chromosome 10 monosomy, chromosome 10q deletion syndrome, chromosome 10q26 deletion


Chromosome 10 Information about

Chromosome 10


  • user icon

    Chromosome 10 beatiful post thanks!

    29.10.2014


Chromosome 10
Chromosome 10
Chromosome 10 viewing the topic.
Chromosome 10 what, Chromosome 10 who, Chromosome 10 explanation

There are excerpts from wikipedia on this article and video

Random Posts

Ralph Neville, 2nd Earl of Westmorland

Ralph Neville, 2nd Earl of Westmorland

Ralph Neville, 2nd Earl of Westmorland 4 April 1406 – 3 November 1484 was an English peer Content...
Mamprusi language

Mamprusi language

The Mamprusi language, Mampruli Mampelle, Ŋmampulli, is a Gur language spoken in northern Ghana by t...
Singapore Changi Airport

Singapore Changi Airport

Singapore Changi Airport IATA: SIN, ICAO: WSSS, or simply Changi Airport, is the primary civili...
Christian Siriano

Christian Siriano

Christian Siriano born November 18, 1985 is an American fashion designer and member of the Council o...