Ceftolozane is a novel cephalosporin antibiotic, developed for the treatment of infections with gram-negative bacteria that have become resistant to conventional antibiotics It was studied for urinary tract infections, intra-abdominal infections and ventilator-associated bacterial pneumonia Ceftolozane is combined with the β-lactamase inhibitor tazobactam, which protects ceftolozane from degradation Ceftolozane-tazobactam trade name Zerbaxa is indicated for the treatment of complicated urinary tract infections and complicated intra abdominal infections
Spectrum of activity
The in vitro activity of ceftolozane–tazobactam has been examined in five surveillance studies of isolates from Europe and North America In these studies, ceftolozane–tazobactam was notable for its activity against Pseudomonas aeruginosa, a moderately common cause of hospital-acquired infections that is commonly multi-drug resistant Ninety percent of P aeruginosa isolates were inhibited by a ceftolozane–tazobactam at a concentration of 4 μg/mL MIC90, making it the most potent anti-pseudomonal antibiotic in clinical use
In these same studies, ceftolozane–tazobactam exhibited MIC90 values of <1 μg/mL for Escherichia coli, Citrobacter koseri, Morganella morganii, Proteus mirabilis, Salmonella species, and Serratia marcescens Somewhat poorer activity is observed for the Klebsiella and Enterobacter species, with the MIC90 for extended spectrum beta-lactamase ESBL expressing Klebsiella pneumonia being >32 μg/mL
- ^ Long, T E; Williams, J T 2014 "Cephalosporins currently in early clinical trials for the treatment of bacterial infections" Expert Opinion on Investigational Drugs 23 10: 1375 doi:101517/135437842014930127
- ^ Takeda, S; Nakai, T; Wakai, Y; Ikeda, F; Hatano, K 2007 "In vitro and in vivo activities of a new cephalosporin, FR264205, against Pseudomonas aeruginosa" Antimicrobial Agents and Chemotherapy 51 3: 826–30 doi:101128/AAC00860-06 PMC 1803152 PMID 17145788
- ^ Toda, A; Ohki, H; Yamanaka, T; Murano, K; Okuda, S; Kawabata, K; Hatano, K; Matsuda, K; Misumi, K; Itoh, K; Satoh, K; Inoue, S 2008 "Synthesis and SAR of novel parenteral anti-pseudomonal cephalosporins: Discovery of FR264205" Bioorganic & Medicinal Chemistry Letters 18 17: 4849–52 doi:101016/jbmcl200807085 PMID 18701284
- ^ Sader, H S; Rhomberg, P R; Farrell, D J; Jones, R N 2011 "Antimicrobial activity of CXA-101, a novel cephalosporin tested in combination with tazobactam against Enterobacteriaceae, Pseudomonas aeruginosa, and Bacteroides fragilis strains having various resistance phenotypes" Antimicrobial Agents and Chemotherapy 55 5: 2390–4 doi:101128/AAC01737-10 PMC 3088243 PMID 21321149
- ^ Craig, W A; Andes, D R 2013 "In vivo activities of ceftolozane, a new cephalosporin, with and without tazobactam against Pseudomonas aeruginosa and Enterobacteriaceae, including strains with extended-spectrum β-lactamases, in the thighs of neutropenic mice" Antimicrobial Agents and Chemotherapy 57 4: 1577–82 doi:101128/AAC01590-12 PMC 3623364 PMID 23274659
- ^ Zhanel, G G; Chung, P; Adam, H; Zelenitsky, S; Denisuik, A; Schweizer, F; Lagacé-Wiens, P R; Rubinstein, E; Gin, A S; Walkty, A; Hoban, D J; Lynch Jp, 3rd; Karlowsky, J A 2014 "Ceftolozane/tazobactam: A novel cephalosporin/β-lactamase inhibitor combination with activity against multidrug-resistant gram-negative bacilli" Drugs 74 1: 31–51 doi:101007/s40265-013-0168-2 PMID 24352909
- ^ http://wwwfdagov/NewsEvents/Newsroom/PressAnnouncements/ucm427534htm
- ^ "wwwaccessdatafdagov" PDF
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