Mon . 19 Apr 2019


cefoperazone sulbactam, cefoperazone
Cefoperazone is a third-generation cephalosporin antibiotic, marketed by Pfizer under the name Cefobid It is one of few cephalosporin antibiotics effective in treating Pseudomonas bacterial infections which are otherwise resistant to these antibiotics

Cefoperazone is also sold as a co-formulation with sulbactam Cefoperazone exerts its bactericidal effect by inhibiting the bacterial cell wall synthesis, and sulbactam acts as a beta-lactamase inhibitor, to increase the antibacterial activity of cefoperazone against beta-lactamase-producing organisms

Spectrum of bacterial susceptibility

Cefoperazone has a broad spectrum of activity and has been used to target bacteria responsible for causing infections of the respiratory and urinary tract, skin, and the female genital tract The following represents MIC susceptibility data for a few medically significant microorganisms

  • Haemophilus influenzae: 012 - 025 µg/ml
  • Staphylococcus aureus: 0125 - 32 µg/ml
  • Streptococcus pneumoniae: ≤0007 - 1 µg/ml

Adverse effects

Cefoperazone contains an N-methylthiotetrazole NMTT or 1-MTT side chain As the antibiotic is broken down in the body, it releases free NMTT, which can cause hypoprothrombinemia likely due to inhibition of the enzyme vitamin K epoxide reductase and a reaction with ethanol similar to that produced by disulfiram Antabuse, due to inhibition of aldehyde dehydrogenase


  1. ^ "Cefoperazone Cefobid - The Antimicrobial Index Knowledgebase - TOKU-E" antibioticstoku-ecom 
  2. ^ http://wwwtoku-ecom/Assets/MIC/Cefoperazone%20sodiumpdf
  3. ^ Stork CM 2006 "Antibiotics, antifungals, and antivirals" In Nelson LH, Flomenbaum N, Goldfrank LR, Hoffman RL, Howland MD, Lewin NA Goldfrank's toxicologic emergencies New York: McGraw-Hill p 847 ISBN 0-07-143763-0 Retrieved 2009-07-03 

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