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cefamandole nafate, cefamandole injection brand and strength
Cefamandole INN, also known as cephamandole is a second-generation broad-spectrum cephalosporin antibiotic The clinically used form of cefamandole is the formate ester cefamandole nafate, a prodrug which is administered parenterally Cefamandole is no longer available in the United States

The chemical structure of cefamandole, like that of several other cephalosporins, contains an N-methylthiotetrazole NMTT or 1-MTT side chain As the antibiotic is broken down in the body, it releases free NMTT, which can cause hypoprothrombinemia likely due to inhibition of the enzyme vitamin K epoxide reductasevitamin K supplement is recommended during therapy and a reaction with ethanol similar to that produced by disulfiram Antabuse, due to inhibition of aldehyde dehydrogenase

Cefamandole has a broad spectrum of activity and can be used to treat bacterial infections of the skin, bones and joints, urinary tract, and lower respiratory tract The following represents cefamandole MIC susceptibility data for a few medically significant microorganisms

  • Escherichia coli: 012 - 400 μg/ml
  • Haemophilus influenzae: 006 - >16 μg/ml
  • Staphylococcus aureus: 01 - 125 μg/ml

CO2 is generated during the normal constitution of cefamandole and ceftazidime, potentially resulting in an explosive-like reaction in syringes

See also

  • Cefazolin
  • Ceforanide


  1. ^ http://wwwtoku-ecom/Assets/MIC/Cefamandole%20sodium%20saltpdf
  2. ^ Stork CM 2006 "Antibiotics, antifungals, and antivirals" In Nelson LH, Flomenbaum N, Goldfrank LR, Hoffman RL, Howland MD, Lewin NA Goldfrank's toxicologic emergencies New York: McGraw-Hill p 847 ISBN 0-07-143763-0 Retrieved 2009-07-03 

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