CD15cd15, cd150m godwin pump
CD15 3-fucosyl-N-acetyl-lactosamine is a cluster of differentiation antigen - an immunologically significant molecule CD15 is a carbohydrate1 adhesion molecule that can be expressed on glycoproteins, glycolipids and proteoglycans
- 1 Function
- 2 Diagnostic relevance
- 3 See also
- 4 References
CD15 mediates phagocytosis and chemotaxis, found on neutrophils;2 expressed in patients with Hodgkin disease, some B-cell chronic lymphocytic leukemias, acute lymphoblastic leukemias, and most acute nonlymphocytic leukemias It is also called Lewis x and SSEA-1 stage-specific embryonic antigen 1 and represents a marker for murine pluripotent stem cells, in which it plays an important role in adhesion and migration of the cells in the preimplantation embryo It is synthezised by FUT4 fucosyltransferase 4 and FUT93
CD15 is present on almost all Reed–Sternberg cells, including their rare mononuclear variants, and, as such, can be used in immunohistochemistry to identify the presence of such cells in biopsies The presence of these cells is diagnostic of Hodgkin's lymphoma Reed-Sternberg cells display a characteristic pattern of CD15 positivity, with membranous staining combined with staining of the Golgi apparatus Immunohistochemical panels for the diagnosis of Hodgkins disease typically employ CD15 along with CD30 and CD45; the latter does not stain Reed-Sternberg cells, but does stain almost all other lymphoid cells CD15 is also present in about 50% of adenocarcinoma cells and can be used to distinguish such conditions from mesothelioma, which is typically negative4
- Sialyl Lewis X
- ^ CD15 Antigen at the US National Library of Medicine Medical Subject Headings MeSH
- ^ Kerr MA, Stocks SC November 1992 "The role of CD15-LeX-related carbohydrates in neutrophil adhesion" Histochem J 24 11: 811–26 PMID 1362195 doi:101007/BF01046353
- ^ Nakayama F, Nishihara S, Iwasaki H, Kudo T, Okubo R, Kaneko M, Nakamura M, Karube M, Sasaki K, Narimatsu H May 2001 "CD15 expression in mature granulocytes is determined by alpha 1,3-fucosyltransferase IX, but in promyelocytes and monocytes by alpha 1,3-fucosyltransferase IV" J Biol Chem 276 19: 16100–6 PMID 11278338 doi:101074/jbcM007272200
- ^ Leong, Anthony S-Y; Cooper, Kumarason; Leong, F Joel W-M 2003 Manual of Diagnostic Cytology 2 ed Greenwich Medical Media, Ltd pp 83–84 ISBN 1-84110-100-1
cd15, cd15 immunohistochemistry, cd15 neutrophils, cd15 pathology outlines, cd150, cd150m godwin pump, cd151, cd152, cd154, cd155
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