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ccl18 and cd163, ccl18 receptor

Identifiers Aliases CCL18, chemokine C-C motif ligand 18 pulmonary and activation-regulated, AMAC-1, AMAC1, CKb7, DC-CK1, DCCK1, MIP-4, PARC, SCYA18, C-C motif chemokine ligand 18 External IDs HomoloGene: 48154 GeneCards: CCL18
Gene location Human
Chr Chromosome 17 human
Band 17q12 Start 36,064,280 bp
End 36,072,032 bp
Orthologs Species Human Mouse Entrez
RefSeq mRNA



RefSeq protein



Location UCSC Chr 17: 3606 – 3607 Mb n/a PubMed search n/a Wikidata
  • ^ a b c ENSG00000278167, ENSG00000278006 GRCh38: Ensembl release 89: ENSG00000275385, ENSG00000278167, ENSG00000278006 - Ensembl, May 2017
  • ^ "Human PubMed Reference:" 
  • ^ a b Hieshima K, Imai T, Baba M, Shoudai K, Ishizuka K, Nakagawa T, Tsuruta J, Takeya M, Sakaki Y, Takatsuki K, Miura R, Opdenakker G, Van Damme J, Yoshie O, Nomiyama H August 1997 "A novel human CC chemokine PARC that is most homologous to macrophage-inflammatory protein-1 alpha/LD78 alpha and chemotactic for T lymphocytes, but not for monocytes" J Immunol 159 3: 1140–9 PMID 9233607 
  • ^ a b Politz O, Kodelja V, Guillot P, Orfanos CE, Goerdt S February 2000 "Pseudoexons and regulatory elements in the genomic sequence of the beta-chemokine, alternative macrophage activation-associated CC-chemokine AMAC-1" Cytokine 12 2: 120–6 doi:101006/cyto19990538 PMID 10671296 
  • ^ Tasaki Y, Fukuda S, Iio M, Miura R, Imai T, Sugano S, Yoshie O, Hughes AL, Nomiyama H February 1999 "Chemokine PARC gene SCYA18 generated by fusion of two MIP-1alpha/LD78alpha-like genes" Genomics 55 3: 353–7 doi:101006/geno19985670 PMID 10049593 
  • ^ a b c d e f Schutyser E, Richmond A, Van Damme J July 2005 "Involvement of CC chemokine ligand 18 CCL18 in normal and pathological processes" J Leukoc Biol 78 1: 14–26 doi:101189/jlb1204712 PMC 2665283  PMID 15784687 
  • ^ a b c d Bellinghausen I, Reuter S, Martin H, Maxeiner J, Luxemburger U, Türeci Ö, Grabbe S, Taube C, Saloga J December 2012 "Enhanced production of CCL18 by tolerogenic dendritic cells is associated with inhibition of allergic airway reactivity" J Allergy Clin Immunol 130 6: 1384–93 doi:101016/jjaci201208039 PMID 23102918 
  • ^ Ferrara G, Bleck B, Richeldi L, Reibman J, Fabbri LM, Rom WN, Condos R December 2008 "Mycobacterium tuberculosis induces CCL18 expression in human macrophages" Scand J Immunol 68 6: 668–74 doi:101111/j1365-3083200802182x PMID 18959625 
  • ^ a b c d Schraufstatter IU, Zhao M, Khaldoyanidi SK, Discipio RG April 2012 "The chemokine CCL18 causes maturation of cultured monocytes to macrophages in the M2 spectrum" Immunology 135 4: 287–98 doi:101111/j1365-2567201103541x PMC 3372745  PMID 22117697 
  • ^ a b c Vulcano M, Struyf S, Scapini P, Cassatella M, Bernasconi S, Bonecchi R, Calleri A, Penna G, Adorini L, Luini W, Mantovani A, Van Damme J, Sozzani S April 2003 "Unique regulation of CCL18 production by maturing dendritic cells" J Immunol 170 7: 3843–9 doi:104049/jimmunol17073843 PMID 12646652 
  • ^ Adema GJ, Hartgers F, Verstraten R, de Vries E, Marland G, Menon S, Foster J, Xu Y, Nooyen P, McClanahan T, Bacon KB, Figdor CG June 1997 "A dendritic-cell-derived C-C chemokine that preferentially attracts naive T cells" Nature 387 6634: 713–7 doi:101038/42716 PMID 9192897 
  • ^ Chenivesse C, Chang Y, Azzaoui I, Ait Yahia S, Morales O, Plé C, Foussat A, Tonnel AB, Delhem N, Yssel H, Vorng H, Wallaert B, Tsicopoulos A July 2012 "Pulmonary CCL18 recruits human regulatory T cells" J Immunol 189 1: 128–37 doi:104049/jimmunol1003616 PMID 22649201 
  • ^ a b c d de Nadaï P, Charbonnier AS, Chenivesse C, Sénéchal S, Fournier C, Gilet J, Vorng H, Chang Y, Gosset P, Wallaert B, Tonnel AB, Lassalle P, Tsicopoulos A May 2006 "Involvement of CCL18 in allergic asthma" J Immunol 176 10: 6286–93 doi:104049/jimmunol176106286 PMID 16670340 
  • ^ Li HY, Cui XY, Wu W, Yu FY, Yao HR, Liu Q, Chen JQ October 2013 "Pyk2 and Src mediate signaling to CCL18-induced breast cancer metastasis" J Cell Biochem 115: 596–603 doi:101002/jcb24697 PMID 24142406 
  • ^ a b Chen J, Yao Y, Gong C, Yu F, Su S, Chen J, Liu B, Deng H, Wang F, Lin L, Yao H, Su F, Anderson KS, Liu Q, Ewen ME, Yao X, Song E April 2011 "CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3" Cancer Cell 19 4: 541–55 doi:101016/jccr201102006 PMC 3107500  PMID 21481794 
  • ^ Catusse J, Wollner S, Leick M, Schröttner P, Schraufstätter I, Burger M November 2010 "Attenuation of CXCR4 responses by CCL18 in acute lymphocytic leukemia B cells" J Cell Physiol 225 3: 792–800 doi:101002/jcp22284 PMID 20568229 
  • ^ a b Islam SA, Ling MF, Leung J, Shreffler WG, Luster AD September 2013 "Identification of human CCR8 as a CCL18 receptor" J Exp Med 210 10: 1889–98 doi:101084/jem20130240 PMC 3782048  PMID 23999500 
  • ^ Kodelja V, Müller C, Politz O, Hakij N, Orfanos CE, Goerdt S February 1998 "Alternative macrophage activation-associated CC-chemokine-1, a novel structural homologue of macrophage inflammatory protein-1 alpha with a Th2-associated expression pattern" J Immunol 160 3: 1411–8 PMID 9570561 
  • ^ Bruna-Romero O, Schmieg J, Del Val M, Buschle M, Tsuji M March 2003 "The dendritic cell-specific chemokine, dendritic cell-derived CC chemokine 1, enhances protective cell-mediated immunity to murine malaria" J Immunol 170 6: 3195–203 doi:104049/jimmunol17063195 PMID 12626578 
  • ^ Lindhout E, Vissers JL, Hartgers FC, Huijbens RJ, Scharenborg NM, Figdor CG, Adema GJ March 2001 "The dendritic cell-specific CC-chemokine DC-CK1 is expressed by germinal center dendritic cells and attracts CD38-negative mantle zone B lymphocytes" J Immunol 166 5: 3284–9 doi:104049/jimmunol16653284 PMID 11207283 
  • ^ Azzaoui I, Yahia SA, Chang Y, Vorng H, Morales O, Fan Y, Delhem N, Ple C, Tonnel AB, Wallaert B, Tsicopoulos A September 2011 "CCL18 differentiates dendritic cells in tolerogenic cells able to prime regulatory T cells in healthy subjects" Blood 118 13: 3549–58 doi:101182/blood-2011-02-338780 PMID 21803856 
  • ^ Radstake TR, van der Voort R, ten Brummelhuis M, de Waal Malefijt M, Looman M, Figdor CG, van den Berg WB, Barrera P, Adema GJ March 2005 "Increased expression of CCL18, CCL19, and CCL17 by dendritic cells from patients with rheumatoid arthritis, and regulation by Fc gamma receptors" Ann Rheum Dis 64 3: 359–67 doi:101136/ard2003017566 PMC 1755402  PMID 15331393 
  • External links

    • Human CCL18 genome location and CCL18 gene details page in the UCSC Genome Browser

    ccl18, ccl18 and cd163, ccl18 elisa, ccl18 gene, ccl18 mouse, ccl18 protein, ccl18 receptor

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