Carl Ferdinand Cori


Carl Ferdinand Cori, ForMemRS2 December 5, 1896 – October 20, 1984 was a Czech-American biochemist and pharmacologist born in Prague34 then in Austria-Hungary, now Czech Republic who, together with his wife Gerty Cori and Argentine physiologist Bernardo Houssay, received a Nobel Prize in 194756789 for their discovery of how glycogen animal starch – a derivative of glucose – is broken down and resynthesized in the body, for use as a store and source of energy In 2004 both were designated a National Historic Chemical Landmark in recognition of their work that elucidated carbohydrate metabolism1011121314 15

Contents

  • 1 Education and early life
  • 2 Career
  • 3 Awards and honors
  • 4 References

Education and early lifeedit

Carl was the son of Carl Isidor Coride 1865, Brüx Czech: Most, RBohemia, ImpAustria–1954, Vienna, a zoologist, and Maria née Lippichde 1870, Graz–1922, Prague, a daughter of the Italian-Bohemian/Austrian physician Ferdinand Franz Lippichde 1838, Padova–1913, Prague1617

The Coride Family came from the Papal State later Republical Rome, today's Central Italy to the Royal Bohemian Crownland, Austrian Circle Monarchical Austria centered on the Archducal Austria at the end of the 17th century Carl Ferdinand's grandfather Eduard Cori 1812–188918 was an administrative officer and beekeeper in Brüx, and grandmother was Rosina Trinks –190919 Carl Ferdinand's younger sister Margarete Cori born 1905 was a lecturer of Prague and the wife of the Bohemian geneticist Felix Mainx 1900, Prague–1983, Vienna2021

He grew up in Trieste, where his father Carl Isidor was the director of the Marine Biological Station In late 1914 the Cori family moved to Prague and Carl entered the medical school of Charles University in Prague While studying there he met Gerty Theresa Radnitz He was drafted into the Austro-Hungarian Army and served in the ski corps, and later was transferred to the sanitary corps, for which he set up a laboratory in Trieste At the end of the war Carl completed his studies, graduating with Gerty in 1920 Carl and Gerty married that year and worked together in clinics in Vienna

Careeredit

Carl was invited to Graz to work with Otto Loewi to study the effect of the vagus nerve on the heart Loewi would receive the Nobel Prize in Physiology or Medicine in 1936 for this work While Carl was in Graz, Gerty remained in Vienna A year later Carl was offered a position at the State Institute for the Study of Malignant Diseases now the Roswell Park Cancer Institute in Buffalo, New York and the Cori's moved to Buffalo In 1928, they became naturalized citizens of the United States

While at the Institute the Coris’ research focused on carbohydrate metabolism, leading to the definition of the Cori cycle in 1929 In 1931 Carl accepted a position at the Washington University School of Medicine in St Louis, Missouri Carl joined as professor of pharmacology and in 1942 was made professor of biochemistry In St Louis, the Cori's continued their research on glycogen and glucose and began to describe glycogenolysis, identifying and synthesizing the important enzyme glycogen phosphorylase For these discoveries, they received the Nobel Prize in Physiology or Medicine in 1947

Gerty died in 1957 and Carl married Anne Fitz-Gerald Jones in 1960 He stayed on at Washington University until 1966, when he retired as chair of the biochemistry department He was appointed visiting professor of Biological Chemistry at Harvard University while maintaining a laboratory space at the Massachusetts General Hospital, where he pursued research in genetics From 1968 to 1983 he collaborated with noted geneticist Salomé Glüecksohn-Waelsch of the Albert Einstein College of Medicine in New York, until the 1980s when illness prevented him from continuing22 In 1976 Carl received the Laurea honoris causa in Medicine from the University of Trieste Carl shares a star with Gerty on the St Louis Walk of Fame23

Awards and honorsedit

In addition to winning the Nobel Prize, Cori won the Albert Lasker Award for Basic Medical Research in 1946 and in 1959, the Austrian Decoration for Science and Art24 Cori was elected a Foreign Member of the Royal Society ForMemRS in 19502 and the Carl Cori Endowed Professorship at Washington University is named in his honor, currently held by Colin Nichols25

Referencesedit

  1. ^ Kornberg, A 2001 "Remembering our teachers" The Journal of Biological Chemistry 276 1: 3–11 PMID 11134064 
  2. ^ a b c Randle, Philip 1986 "Carl Ferdinand Cori 5 December 1896-20 October 1984" Biographical Memoirs of Fellows of the Royal Society 32: 66–95 doi:101098/rsbm19860003 JSTOR 770108 PMID 11621260 
  3. ^ Cohn, M 1992 "Carl Ferdinand Cori: December 5, 1896-October 19, 1984" Biographical memoirs National Academy of Sciences US 61: 79–109 PMID 11616228 
  4. ^ Houssay, B A 1956 "Carl F And Gerty T Cori" Biochimica et Biophysica Acta 20 1: 11–16 doi:101016/0006-30025690255-4 PMID 13315342 
  5. ^ Cech, P 2008 "Nobel Prize laureates" Casopis lekaru ceskych 147 7: 410–412 PMID 18678102 
  6. ^ Cech, P 2001 "The Coris, a married couple native to Prague and Nobel laureates" Casopis lekaru ceskych 140 1: 26–30 PMID 11242981 
  7. ^ Shampo, M A; Kyle, R A 2000 "Carl Cori—Nobel Laureate in Medicine or Physiology" Mayo Clinic Proceedings 75 12: 1274 doi:104065/75121274 PMID 11126836 
  8. ^ Raju, T N 1999 "The Nobel Chronicles 1947: Carl Ferdinand Cori 1896-1984; Gerty Theresa Radnitz Cori 1896-1957; and Bernardo Alberto Houssay 1887-1971" Lancet 353 9158: 1108 PMID 10199387 
  9. ^ Sulek, K 1968 "Nobel prize for Carl Ferdinand Cori and Gerta Theresa Cori in 1947 for discovery of the course of catalytic metabolism of glycogen Prize for Alberto Bernardo Houssay for discovery on the role of the hypophysis in carbohydrate metabolism" Wiadomosci lekarskie Warsaw, Poland : 1960 21 17: 1609–1610 PMID 4882480 
  10. ^ "Carl and Gerti Cori and Carbohydrate Metabolism" American Chemical Society Retrieved June 6, 2012 
  11. ^ Kenéz, J 1977 "Liver glycogen and enzyme research Carl Ferdinand CPORI" Orvosi hetilap 118 8: 463–465 PMID 320540 
  12. ^ Cori, C F 1969 "The Call of Science" Annual Review of Biochemistry 38: 1–20 doi:101146/annurevbi38070169000245 PMID 4896237 
  13. ^ Carl Ferdinand Cori — Biographical Memoirs of the National Academy of Sciences
  14. ^ Ihde, AJ Cori, Carl Ferdinand, and Gerty Theresa Radnitz Cori American National Biography Online Feb 2000
  15. ^ Carl and Gerti Cori and Carbohydrate Metabolism from American Chemical Society National Historic Chemical Landmarks
  16. ^ Dolezal, Helmut, "Cori, Carl Isidor" in: Neue Deutsche Biographie 3 1957, p 360
  17. ^ 1, 2, 3
  18. ^ 4, 5, commons:File:Anonym - Franz Eduard Corijpg
  19. ^ 6
  20. ^ 7
  21. ^ de:Carl Isidor Cori#Familie
  22. ^ Ginsberg, Judah September 21, 2004 "Carl and Gerty Cori and Carbohydrate Metabolism" National Historic Chemical Landmark American Chemical Society Retrieved August 28, 2012 
  23. ^ St Louis Walk of Fame "St Louis Walk of Fame Inductees" stlouiswalkoffameorg Retrieved 25 April 2013 
  24. ^ "Reply to a parliamentary question" pdf in German p 73 Retrieved 28 December 2012 
  25. ^ Colin G Nichols named Carl F Cori Professor, Washington University in St Louis, 2007-02-21


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