Wed . 20 Jul 2020
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C-Met

c-met antibody, c-met
1FYR, 1R0P, 1R1W, 1SHY, 1SSL, 2G15, 2RFN, 2RFS, 2UZX, 2UZY, 2WD1, 2WGJ, 2WKM, 3A4P, 3BUX, 3C1X, 3CCN, 3CD8, 3CE3, 3CTH, 3CTJ, 3DKC, 3DKF, 3DKG, 3EFJ, 3EFK, 3F66, 3F82, 3I5N, 3L8V, 3LQ8, 3Q6U, 3Q6W, 3QTI, 3R7O, 3RHK, 3U6H, 3U6I, 3VW8, 3ZBX, 3ZC5, 3ZCL, 3ZXZ, 3ZZE, 4AOI, 4AP7, 4DEG, 4DEH, 4DEI, 4EEV, 4GG7, 4IWD, 4K3J, 4KNB, 4MXC, 4O3T, 4O3U, 4R1V, 4R1Y, 4XMO, 4XYF, 5EYC, 5EYD

Identifiers Aliases MET, MET proto-oncogene, receptor tyrosine kinase, AUTS9, HGFR, RCCP2, c-Met, DFNB97, OSFD External IDs MGI: 96969 HomoloGene: 206 GeneCards: MET RNA expression pattern



More reference expression data Orthologs Species Human Mouse Entrez
Ensembl
UniProt
RefSeq mRNA

NM_000245
NM_001127500
NM_001324401
NM_001324402

NM_008591

RefSeq protein

NP_000236
NP_001120972
NP_001311330
NP_001311331

n/a

Location UCSC Chr 7: 11667 – 1168 Mb Chr 6: 1746 – 1757 Mb PubMed search 1 2 Wikidata
  • ^ "Human PubMed Reference:" 
  • ^ "Mouse PubMed Reference:" 
  • ^ Bottaro DP, Rubin JS, Faletto DL, Chan AM, Kmiecik TE, Vande Woude GF, Aaronson SA February 1991 "Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product" Science 251 4995: 802–4 PMID 1846706 doi:101126/science1846706 
  • ^ Galland F, Stefanova M, Lafage M, Birnbaum D 1992 "Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23" Cytogenet Cell Genet 60 2: 114–6 PMID 1611909 doi:101159/000133316 
  • ^ Cooper CS January 1992 "The met oncogene: from detection by transfection to transmembrane receptor for hepatocyte growth factor" Oncogene 7 1: 3–7 PMID 1531516 
  • ^ Johnson M, Koukoulis G, Kochhar K, Kubo C, Nakamura T, Iyer A Sep 1995 "Selective tumorigenesis in non-parenchymal liver epithelial cell lines by hepatocyte growth factor transfection" Cancer Letters 96 1: 37–48 PMID 7553606 doi:101016/0304-38359503915-j 
  • ^ Kochhar KS, Johnson ME, Volpert O, Iyer AP 1995 "Evidence for autocrine basis of transformation in NIH-3T3 cells transfected with met/HGF receptor gene" Growth Factors 12 4: 303–13 PMID 8930021 doi:103109/08977199509028968 
  • ^ "Entrez Gene: MET met proto-oncogene hepatocyte growth factor receptor" 
  • ^ Dean M, Park M, Le Beau MM, Robins TS, Diaz MO, Rowley JD, Blair DG, Vande Woude GF 1985 "The human met oncogene is related to the tyrosine kinase oncogenes" Nature 318 6044: 385–8 PMID 4069211 doi:101038/318385a0 
  • ^ a b c d e f Gentile A, Trusolino L, Comoglio PM March 2008 "The Met tyrosine kinase receptor in development and cancer" Cancer Metastasis Rev 27 1: 85–94 PMID 18175071 doi:101007/s10555-007-9107-6 
  • ^ a b Birchmeier C, Birchmeier W, Gherardi E, Vande Woude GF December 2003 "Met, metastasis, motility and more" Nat Rev Mol Cell Biol 4 12: 915–25 PMID 14685170 doi:101038/nrm1261 
  • ^ Gandino L, Longati P, Medico E, Prat M, Comoglio PM January 1994 "Phosphorylation of serine 985 negatively regulates the hepatocyte growth factor receptor kinase" J Biol Chem 269 3: 1815–20 PMID 8294430 
  • ^ Peschard P, Fournier TM, Lamorte L, Naujokas MA, Band H, Langdon WY, Park M November 2001 "Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein" Mol Cell 8 5: 995–1004 PMID 11741535 doi:101016/S1097-27650100378-1 
  • ^ a b Ponzetto C, Bardelli A, Zhen Z, Maina F, dalla Zonca P, Giordano S, Graziani A, Panayotou G, Comoglio PM April 1994 "A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family" Cell 77 2: 261–71 PMID 7513258 doi:101016/0092-86749490318-2 
  • ^ Maina F, Casagranda F, Audero E, Simeone A, Comoglio PM, Klein R, Ponzetto C November 1996 "Uncoupling of Grb2 from the Met receptor in vivo reveals complex roles in muscle development" Cell 87 3: 531–42 PMID 8898205 doi:101016/S0092-86740081372-0 
  • ^ a b c d Abounader R, Reznik T, Colantuoni C, Martinez-Murillo F, Rosen EM, Laterra J December 2004 "Regulation of c-Met-dependent gene expression by PTEN" Oncogene 23 57: 9173–82 PMID 15516982 doi:101038/sjonc1208146 
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  • ^ Gual P, Giordano S, Williams TA, Rocchi S, Van Obberghen E, Comoglio PM March 2000 "Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesis" Oncogene 19 12: 1509–18 PMID 10734310 doi:101038/sjonc1203514 
  • ^ O'Brien LE, Tang K, Kats ES, Schutz-Geschwender A, Lipschutz JH, Mostov KE July 2004 "ERK and MMPs sequentially regulate distinct stages of epithelial tubule development" Dev Cell 7 1: 21–32 PMID 15239951 doi:101016/jdevcel200406001 
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  • ^ Monga SP, Mars WM, Pediaditakis P, Bell A, Mulé K, Bowen WC, Wang X, Zarnegar R, Michalopoulos GK April 2002 "Hepatocyte growth factor induces Wnt-independent nuclear translocation of beta-catenin after Met-beta-catenin dissociation in hepatocytes" Cancer Res 62 7: 2064–71 PMID 11929826 
  • ^ Gude NA, Emmanuel G, Wu W, Cottage CT, Fischer K, Quijada P, Muraski JA, Alvarez R, Rubio M, Schaefer E, Sussman MA May 2008 "Activation of Notch-mediated protective signaling in the myocardium" Circ Res 102 9: 1025–35 PMID 18369158 doi:101161/CIRCRESAHA107164749 
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  • ^ a b Arechederra M, Carmona R, González-Nuñez M, Gutiérrez-Uzquiza A, Bragado P, Cruz-González I, Cano E, Guerrero C, Sánchez A, López-Novoa JM, Schneider MD, Maina F, Muñoz-Chápuli R, Porras A Dec 2013 "Met signaling in cardiomyocytes is required for normal cardiac function in adult mice" Biochimica et Biophysica Acta 1832 12: 2204–15 PMID 23994610 doi:101016/jbbadis201308008 
  • ^ Leo C, Sala V, Morello M, Chiribiri A, Riess I, Mancardi D, Schiaffino S, Ponzetto C, Crepaldi T 2011-02-09 "Activated Met signalling in the developing mouse heart leads to cardiac disease" PLOS ONE 6 2: e14675 PMC 3036588  PMID 21347410 doi:101371/journalpone0014675 
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  • ^ Pennacchietti S, Michieli P, Galluzzo M, Mazzone M, Giordano S, Comoglio PM April 2003 "Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene" Cancer Cell 3 4: 347–61 PMID 12726861 doi:101016/S1535-61080300085-0 
  • ^ "HGF/c-Met and cancer" HealthValue Retrieved 2009-06-13 
  • ^ Kim S, Lee UJ, Kim MN, Lee EJ, Kim JY, Lee MY, Choung S, Kim YJ, Choi YC June 2008 "MicroRNA miR-199a regulates the MET proto-oncogene and the downstream extracellular signal-regulated kinase 2 ERK2" J Biol Chem 283 26: 18158–66 PMID 18456660 doi:101074/jbcM800186200 
  • ^ del Carmen MG, Birrer M, Schorge JO September 2012 "Clear cell carcinoma of the ovary: a review of the literature" Gynecol Oncol 126 3: 481–90 PMID 22525820 doi:101016/jygyno201204021 
  • ^ Bardelli A, Corso S, Bertotti A, Hobor S, Valtorta E, Siravegna G, Sartore-Bianchi A, Scala E, Cassingena A, Zecchin D, Apicella M, Migliardi G, Galimi F, Lauricella C, Zanon C, Perera T, Veronese S, Corti G, Amatu A, Gambacorta M, Diaz LA, Sausen M, Velculescu VE, Comoglio P, Trusolino L, Di Nicolantonio F, Giordano S, Siena S June 2013 "Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer" Cancer Discov 3 6: 658–73 PMC 4078408  PMID 23729478 doi:101158/2159-8290CD-12-0558 
  • ^ Campbell DB, Sutcliffe JS, Ebert PJ, Militerni R, Bravaccio C, Trillo S, Elia M, Schneider C, Melmed R, Sacco R, Persico AM, Levitt P 2006 "A genetic variant that disrupts MET transcription is associated with autism" Proc Natl Acad Sci USA 103 45: 16834–9 PMC 1838551  PMID 17053076 doi:101073/pnas0605296103 
  • ^ Campbell DB, Buie TM, Winter H, Bauman M, Sutcliffe JS, Perrin JM, Levitt P 2009 "Distinct genetic risk based on association of MET in families with co-occurring autism and gastrointestinal conditions" Pediatrics 123 3: 1018–24 PMID 19255034 doi:101542/peds2008-0819 
  • ^ Lambert N, Wermenbol V, Pichon B, Acosta S, van den Ameele J, Perazzolo C, Messina D, Musumeci MF, Dessars B, De Leener A, Abramowicz M, Vilain C 2014 "A familial heterozygous null mutation of MET in autism spectrum disorder" Autism Res 7 5: 617–22 PMID 24909855 doi:101002/aur1396 
  • ^ Qiu S, Lu Z, Levitt P 2014 "MET receptor tyrosine kinase controls dendritic complexity, spine morphogenesis, and glutamatergic synapse maturation in the hippocampus" J Neurosci 34 49: 16166–79 PMC 4252539  PMID 25471559 doi:101523/JNEUROSCI2580-142014 
  • ^ Eagleson KL, Milner TA, Xie Z, Levitt P 2013 "Synaptic and extrasynaptic location of the receptor tyrosine kinase met during postnatal development in the mouse neocortex and hippocampus" J Comp Neurol 521 14: 3241–59 PMC 3942873  PMID 23787772 doi:101002/cne23343 
  • ^ Judson MC, Eagleson KL, Levitt P 2011 "A new synaptic player leading to autism risk: Met receptor tyrosine kinase" J Neurodev Disord 3 3: 282–92 PMC 3261279  PMID 21509596 doi:101007/s11689-011-9081-8 
  • ^ Qiu S, Anderson CT, Levitt P, Shepherd GM 2011 "Circuit-specific intracortical hyperconnectivity in mice with deletion of the autism-associated Met receptor tyrosine kinase" J Neurosci 31 15: 5855–64 PMC 3086026  PMID 21490227 doi:101523/JNEUROSCI6569-102011 
  • ^ Judson MC, Eagleson KL, Wang L, Levitt P 2010 "Evidence of cell-nonautonomous changes in dendrite and dendritic spine morphology in the met-signaling-deficient mouse forebrain" J Comp Neurol 518 21: 4463–78 PMC 2952412  PMID 20853516 doi:101002/cne22467 
  • ^ Rudie JD, Hernandez LM, Brown JA, Beck-Pancer D, Colich NL, Gorrindo P, Thompson PM, Geschwind DH, Bookheimer SY, Levitt P, Dapretto M "Autism-associated promoter variant in MET impacts functional and structural brain networks" Neuron 75: 904–15 PMC 3454529  PMID 22958829 doi:101016/jneuron201207010 
  • ^ Doherty KR, Wappel RL, Talbert DR, Trusk PB, Moran DM, Kramer JW, Brown AM, Shell SA, Bacus S October 2013 "Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes" Toxicology and Applied Pharmacology 272 1: 245–55 PMID 23707608 doi:101016/jtaap201304027 
  • ^ Aguirre SA, Heyen JR, Collette W, Bobrowski W, Blasi ER April 2010 "Cardiovascular effects in rats following exposure to a receptor tyrosine kinase inhibitor" Toxicologic Pathology 38 3: 416–28 PMID 20231546 doi:101177/0192623310364027 
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  • ^ Sala V, Crepaldi T May 2011 "Novel therapy for myocardial infarction: can HGF/Met be beneficial" Cellular and Molecular Life Sciences 68 10: 1703–17 PMID 21327916 doi:101007/s00018-011-0633-6 
  • ^ Maehama T, Dixon JE May 1998 "The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate" J Biol Chem 273 22: 13375–8 PMID 9593664 doi:101074/jbc2732213375 
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  • ^ Lei L, Mason S, Liu D, Huang Y, Marks C, Hickey R, Jovin IS, Pypaert M, Johnson RS, Giordano FJ June 2008 "Hypoxia-inducible factor-dependent degeneration, failure, and malignant transformation of the heart in the absence of the von Hippel-Lindau protein" Molecular and Cellular Biology 28 11: 3790–803 PMC 2423296  PMID 18285456 doi:101128/MCB01580-07 
  • ^ Morotti A, Mila S, Accornero P, Tagliabue E, Ponzetto C July 2002 "K252a inhibits the oncogenic properties of Met, the HGF receptor" Oncogene 21 32: 4885–93 PMID 12118367 doi:101038/sjonc1205622 
  • ^ Berthou S, Aebersold DM, Schmidt LS, Stroka D, Heigl C, Streit B, Stalder D, Gruber G, Liang C, Howlett AR, Candinas D, Greiner RH, Lipson KE, Zimmer Y July 2004 "The Met kinase inhibitor SU11274 exhibits a selective inhibition pattern toward different receptor mutated variants" Oncogene 23 31: 5387–93 PMID 15064724 doi:101038/sjonc1207691 
  • ^ Wang X, Le P, Liang C, Chan J, Kiewlich D, Miller T, Harris D, Sun L, Rice A, Vasile S, Blake RA, Howlett AR, Patel N, McMahon G, Lipson KE November 2003 "Potent and selective inhibitors of the Met hepatocyte growth factor/scatter factor HGF/SF receptor tyrosine kinase block HGF/SF-induced tumor cell growth and invasion" Mol Cancer Ther 2 11: 1085–92 PMID 14617781 
  • ^ Christensen JG, Schreck R, Burrows J, Kuruganti P, Chan E, Le P, Chen J, Wang X, Ruslim L, Blake R, Lipson KE, Ramphal J, Do S, Cui JJ, Cherrington JM, Mendel DB November 2003 "A selective small molecule inhibitor of c-Met kinase inhibits c-Met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo" Cancer Res 63 21: 7345–55 PMID 14612533 
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  • ^ Poster
  • ^ Matsumoto K, Nakamura T April 2003 "NK4 HGF-antagonist/angiogenesis inhibitor in cancer biology and therapeutics" Cancer Sci 94 4: 321–7 PMID 12824898 doi:101111/j1349-70062003tb01440x 
  • ^ Cao B, Su Y, Oskarsson M, Zhao P, Kort EJ, Fisher RJ, Wang LM, Vande Woude GF June 2001 "Neutralizing monoclonal antibodies to hepatocyte growth factor/scatter factor HGF/SF display antitumor activity in animal models" Proc Natl Acad Sci USA 98 13: 7443–8 PMC 34688  PMID 11416216 doi:101073/pnas131200498 
  • ^ Burgess T, Coxon A, Meyer S, Sun J, Rex K, Tsuruda T, Chen Q, Ho SY, Li L, Kaufman S, McDorman K, Cattley RC, Sun J, Elliott G, Zhang K, Feng X, Jia XC, Green L, Radinsky R, Kendall R February 2006 "Fully human monoclonal antibodies to hepatocyte growth factor with therapeutic potential against hepatocyte growth factor/c-Met-dependent human tumors" Cancer Res 66 3: 1721–9 PMID 16452232 doi:101158/0008-5472CAN-05-3329 
  • ^ Mazzone M, Basilico C, Cavassa S, Pennacchietti S, Risio M, Naldini L, Comoglio PM, Michieli P November 2004 "An uncleavable form of pro-scatter factor suppresses tumor growth and dissemination in mice" J Clin Invest 114 10: 1418–32 PMC 525743  PMID 15545993 doi:101172/JCI22235 
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  • ^ Jin H, Yang R, Zheng Z, Romero M, Ross J, Bou-Reslan H, Carano RA, Kasman I, Mai E, Young J, Zha J, Zhang Z, Ross S, Schwall R, Colbern G, Merchant M June 2008 "MetMAb, the one-armed 5D5 anti-c-Met antibody, inhibits orthotopic pancreatic tumor growth and improves survival" Cancer Res 68 11: 4360–8 PMID 18519697 doi:101158/0008-5472CAN-07-5960 
  • ^ Martens T, Schmidt NO, Eckerich C, Fillbrandt R, Merchant M, Schwall R, Westphal M, Lamszus K October 2006 "A novel one-armed anti-c-Met antibody inhibits glioblastoma growth in vivo" Clin Cancer Res 12 20 Pt 1: 6144–52 PMID 17062691 doi:101158/1078-0432CCR-05-1418 
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  • ^ Petrelli A, Gilestro GF, Lanzardo S, Comoglio PM, Migone N, Giordano S 2002 "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met" Nature 416 6877: 187–90 PMID 11894096 doi:101038/416187a 
  • ^ Ng C, Jackson RA, Buschdorf JP, Sun Q, Guy GR, Sivaraman J 2008 "Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates" EMBO J 27 5: 804–16 PMC 2265755  PMID 18273061 doi:101038/emboj200818 
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  • ^ Ponzetto C, Zhen Z, Audero E, Maina F, Bardelli A, Basile ML, Giordano S, Narsimhan R, Comoglio P 1996 "Specific uncoupling of GRB2 from the Met receptor Differential effects on transformation and motility" J Biol Chem 271 24: 14119–23 PMID 8662889 doi:101074/jbc2712414119 
  • ^ Liang Q, Mohan RR, Chen L, Wilson SE 1998 "Signaling by HGF and KGF in corneal epithelial cells: Ras/MAP kinase and Jak-STAT pathways" Invest Ophthalmol Vis Sci 39 8: 1329–38 PMID 9660480 
  • ^ Comoglio PM 1993 "Structure, biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells" EXS 65: 131–65 PMID 8380735 
  • ^ Naldini L, Weidner KM, Vigna E, Gaudino G, Bardelli A, Ponzetto C, Narsimhan RP, Hartmann G, Zarnegar R, Michalopoulos GK 1991 "Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor" EMBO J 10 10: 2867–78 PMC 452997  PMID 1655405 
  • ^ Hiscox S, Jiang WG 1999 "Association of the HGF/SF receptor, c-met, with the cell-surface adhesion molecule, E-cadherin, and catenins in human tumor cells" Biochem Biophys Res Commun 261 2: 406–11 PMID 10425198 doi:101006/bbrc19991002 
  • ^ Wang D, Li Z, Messing EM, Wu G 2002 "Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM" J Biol Chem 277 39: 36216–22 PMID 12147692 doi:101074/jbcM205111200 
  • Further readingedit

    • Peruzzi B, Bottaro DP 2006 "Targeting the c-Met signaling pathway in cancer" Clin Cancer Res 12 12: 3657–60 PMID 16778093 doi:101158/1078-0432CCR-06-0818 
    • Birchmeier C, Birchmeier W, Gherardi E, Vande Woude GF December 2003 "Met, metastasis, motility and more" Nat Rev Mol Cell Biol 4 12: 915–25 PMID 14685170 doi:101038/nrm1261 
    • Zhang YW, Vande Woude GF February 2003 "HGF/SF-met signaling in the control of branching morphogenesis and invasion" J Cell Biochem 88 2: 408–17 PMID 12520544 doi:101002/jcb10358 
    • Paumelle R, Tulasne D, Kherrouche Z, Plaza S, Leroy C, Reveneau S, Vandenbunder B, Fafeur V, Tulashe D, Reveneau S April 2002 "Hepatocyte growth factor/scatter factor activates the ETS1 transcription factor by a RAS-RAF-MEK-ERK signaling pathway" Oncogene 21 15: 2309–19 PMID 11948414 doi:101038/sjonc1205297 
    • Comoglio PM 1993 "Structure, biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells" EXS 65: 131–65 PMID 8380735 
    • Maulik G, Shrikhande A, Kijima T, Ma PC, Morrison PT, Salgia R 2002 "Role of the hepatocyte growth factor receptor, c-Met, in oncogenesis and potential for therapeutic inhibition" Cytokine Growth Factor Rev 13 1: 41–59 PMID 11750879 doi:101016/S1359-61010100029-6 
    • Ma PC, Maulik G, Christensen J, Salgia R 2003 "c-Met: structure, functions and potential for therapeutic inhibition" Cancer Metastasis Rev 22 4: 309–25 PMID 12884908 doi:101023/A:1023768811842 
    • Knudsen BS, Edlund M 2004 "Prostate cancer and the met hepatocyte growth factor receptor" Adv Cancer Res Advances in Cancer Research 91: 31–67 ISBN 978-0-12-006691-9 PMID 15327888 doi:101016/S0065-230X0491002-0 
    • Dharmawardana PG, Giubellino A, Bottaro DP 2004 "Hereditary papillary renal carcinoma type I" Curr Mol Med 4 8: 855–68 PMID 15579033 doi:102174/1566524043359674 
    • Kemp LE, Mulloy B, Gherardi E 2006 "Signalling by HGF/SF and Met: the role of heparan sulphate co-receptors" Biochem Soc Trans 34 Pt 3: 414–7 PMID 16709175 doi:101042/BST0340414 

    External linksedit

    • Proto-Oncogene Proteins c-met at the US National Library of Medicine Medical Subject Headings MeSH
    • UniProtKB/Swiss-Prot entry P08581: MET_HUMAN, ExPASy Expert Protein Analysis System proteomics server of the Swiss Institute of Bioinformatics SIB
    • A table with references to significant roles of MET in cancer
    • Human MET genome location and MET gene details page in the UCSC Genome Browser
    • Molecular and Cellular Biology portal

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