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Brenner tumour

brenner tumour, brenner tumour pathology outlines
Brenner tumors are an uncommon subtype of the surface epithelial-stromal tumor group of ovarian neoplasms The majority are benign, but some can be malignant1

They are most frequently found incidentally on pelvic examination or at laparotomy2 Brenner tumours very rarely can occur in other locations, including the testes3


  • 1 Presentation
  • 2 Diagnosis
  • 3 Similar conditions
  • 4 Eponym
  • 5 Additional images
  • 6 References
  • 7 External links


On gross pathological examination, they are solid, sharply circumscribed and pale yellow-tan in colour 90% are unilateral arising in one ovary, the other is unaffected The tumours can vary in size from less than 1 centimetre 039 in to 30 centimetres 12 in Borderline and malignant Brenner tumours are possible but each are rare


Micrograph of a Brenner tumour H&E stain High magnification micrograph of a Brenner tumour showing the characteristic coffee bean nuclei H&E stain

Histologically, there are nests of transitional epithelial urothelial cells with longitudinal nuclear grooves coffee bean nuclei lying in abundant fibrous stroma

Similar conditionsedit

Transitional cell carcinoma is an even rarer entity, in which neoplastic transitional epithelial cells similar to transitional cell carcinoma of the bladder are seen in the ovary, without the characteristic stromal/epithelial pattern of a Brenner tumour


It is named for Fritz Brenner 1877–1969, a German surgeon who characterized it in 19074 The term "Brenner tumor" was first used by Robert Meyer, in 19325

Additional imagesedit


  1. ^ Marwah N, Mathur SK, Marwah S, Singh S, Karwasra RK, Arora B 2005 "Malignant Brenner tumour--a case report" Indian J Pathol Microbiol 48 2: 251–2 PMID 16758686 
  2. ^ Green GE, Mortele KJ, Glickman JN, Benson CB 2006 "Brenner tumors of the ovary: sonographic and computed tomographic imaging features" J Ultrasound Med 25 10: 1245–51; quiz 1252–4 PMID 16998096 
  3. ^ Caccamo D, Socias M, Truchet C 1991 "Malignant Brenner tumor of the testis and epididymis" Arch Pathol Lab Med 115 5: 524–7 PMID 2021324 
  4. ^ Lamping JD, Blythe JG 1977 "Bilateral Brenner tumors: a case report and review of the literature" Hum Pathol 8 5: 583–5 PMID 903146 doi:101016/S0046-81777780117-2 
  5. ^ Philipp, Elliot Elias; O'Dowd, Michael J 2000 The history of obstetrics and gynaecology Carnforth, Lancs: Parthenon p 586 ISBN 1-85070-040-0 

External linksedit

  • "Brenner tumour" Medcyclopaedia GE Archived from the original on 2012-02-05 
  • Histology at University of Utah

brenner ovarian tumour, brenner tumour, brenner tumour pathology outlines

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Brenner tumour

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