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Bolivian hemorrhagic fever

bolivian hemorrhagic fever, bolivian hemorrhagic fever virus
Machupo virus

Bolivian hemorrhagic fever
Classification and external resources
Specialty Infectious disease
ICD-10 A961
ICD-9-CM 0787
DiseasesDB 31899
MeSH D006478
edit on Wikidata

Bolivian hemorrhagic fever BHF, also known as black typhus or Ordog Fever, is a hemorrhagic fever and zoonotic infectious disease originating in Bolivia after infection by Machupo virus1

BHF was first identified in 1963 as an ambisense RNA virus of the Arenaviridae family,23 by a research group led by Karl Johnson The mortality rate is estimated at 5 to 30 percent Due to its pathogenicity, Machupo virus requires Biosafety Level Four conditions, the highest level4

In February and March 2007, some 20 suspected BHF cases 3 fatal were reported to the El Servicio Departamental de Salud SEDES in Beni Department, Bolivia, and in February 2008, at least 200 suspected new cases 12 fatal were reported to SEDES5 In November 2011, a SEDES expert involved in a serosurvey to determine the extent of Machupo virus infections in the Department after the discovery of a second confirmed case near the departmental capital of Trinidad in November, 2011, expressed concern about expansion of the virus' distribution outside the endemic zone in Mamoré and Iténez provinces67


  • 1 Epidemiology
    • 11 History
    • 12 Vectors
    • 13 Symptoms
    • 14 Prevention
  • 2 Weaponization
  • 3 Vaccine Research
  • 4 References
    • 41 Bibliography



The disease was first encountered in 1962, in the Bolivian village of San Joachim, hence the name "Bolivian" Hemorrhagic Fever When initial investigations failed to find an arthropod carrier, other sources were sought before finally determining that the disease was carried by infected mice Although mosquitoes were not the cause as originally suspected, the extermination of mosquitoes using DDT to prevent malaria proved to be indirectly responsible for the outbreak in that the accumulation of DDT in various animals along the food chain led to a shortage of cats in the village; subsequently, a mouse plague erupted in the village, leading to an epidemic8


The vector is the vesper mouse Calomys callosus, a rodent indigenous to northern Bolivia Infected animals are asymptomatic and shed the virus in excreta, thereby infecting humans Evidence of person-to-person transmission of BHF exists but is believed to be rare9


The infection has a slow onset with fever, malaise, headache and muscular pains, very similar to Malaria symptoms Petechiae blood spots on the upper body and bleeding from the nose and gums are observed when the disease progresses to the hemorrhagic phase, usually within seven days of onset9


Measures to reduce contact between the vesper mouse and humans may have contributed to limiting the number of outbreaks, with no cases identified between 1973 and 1994 Although there are no cures or vaccine for the disease, a vaccine developed for the genetically related Junín virus which causes Argentine hemorrhagic fever has shown evidence of cross-reactivity to Machupo virus, and may therefore be an effective prophylactic measure for people at high risk of infection Post infection and providing that the person survives the infection, those that have contracted BHF are usually immune to further infection of the disease9


Bolivian hemorrhagic fever was one of three hemorrhagic fevers and one of more than a dozen agents that the United States researched as potential biological weapons before the nation suspended its biological weapons program10 It was also under research by the Soviet Union, under the Biopreparat bureau11

Vaccine Researchedit

Investigational vaccines exist for Argentine hemorrhagic fever and RVF; however, neither is approved by FDA or commonly available in the United Statescitation needed

The structure of the attachment glycoprotein has been determined by X-ray crystallography and this glycoprotein is likely to be an essential component of any successful vaccine12


  1. ^ Public Health Agency of Canada: Machupo Virus Pathogen Safety Data Sheet, http://wwwphac-aspcgcca/lab-bio/res/psds-ftss/machupo-engphp, Date Modified: 2011-02-18
  2. ^ "Machupo" Retrieved 2009-01-22 
  3. ^ Webb PA, Johnson KM, Mackenzie RB, Kuns ML July 1967 "Some characteristics of Machupo virus, causative agent of Bolivian hemorrhagic fever" Am J Trop Med Hyg 16 4: 531–8 PMID 4378149 
  4. ^ Center for Food Security & Public Health and Institute for International Cooperation in Animal Biologics, Iowa State University: Viral Hemorrhagic Fevers Caused by Arenaviruses, http://wwwcfsphiastateedu/Factsheets/pdfs/viral_hemorrhagic_fever_arenaviruspdf, last updated: February 23, 2010
  5. ^ Aguilar PV, Carmago W, Vargas J, Guevara C, Roca Y, Felices V, et al Reemergence of Bolivian hemorrhagic fever, 2007–2008 letter Emerg Infect Dis serial on the Internet 2009 Sep Available from http://wwwnccdcgov/eid/article/15/9/09-0017htm Accessed 2 Dec 2011
  6. ^ "Caso confirmado de fiebre hemorrágica alerta a autoridades benianas," Los Tiemposcom, http://wwwlostiemposcom/diario/actualidad/nacional/20111116/caso-confirmado-de-fiebre-hemorragica-alerta-a-autoridades_149655_310330html, 16/11/2011
  7. ^ "SEDES movilizado para controlar brote de fiebre hemorrágica en Beni; También se Capacita a Los Comunarios y Estudiantes," Lost Tiemposcom, http://wwwlostiemposcom/diario/actualidad/nacional/20111130/sedes-movilizado-para-controlar-brote-de-fiebre-hemorragica-en_151529_314539html, 30/11/2011
  8. ^ Medical Microbiology 2nd edition; Mims et al Mosby publishing 1998, p 371
  9. ^ a b c Kilgore, et al, 1995
  10. ^ "Chemical and Biological Weapons: Possession and Programs Past and Present", James Martin Center for Nonproliferation Studies, Middlebury College, April 9, 2002, accessed November 14, 2008
  11. ^ Alibek, Ken and Steven Handelman 1999, Biohazard: The Chilling True Story of the Largest Covert Biological Weapons Program in the World - Told from Inside by the Man Who Ran It, Random House, ISBN 0-385-33496-6
  12. ^ Bowden, Thomas A; Crispin, Max; Graham, Stephen C; Harvey, David J; Grimes, Jonathan M; Jones, E Yvonne; Stuart, David I 2009-08-15 "Unusual Molecular Architecture of the Machupo Virus Attachment Glycoprotein" Journal of Virology 83 16: 8259–8265 ISSN 0022-538X PMC 2715760  PMID 19494008 doi:101128/JVI00761-09 


  • Kilgore PE, Peters CJ, Mills JN, et al 1995 "Prospects for the control of Bolivian hemorrhagic fever" Emerging Infect Dis 1 3: 97–100 PMC 2626873  PMID 8903174 doi:103201/eid0103950308 


  1. ^ Medical Microbiology 2nd Edition Mims et al Mosby Publishing 1998 p 371

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