Sat . 19 Oct 2019
TR | RU | UK | KK | BE |

Blastomyces dermatitidis

blastomyces dermatitidis, blastomyces dermatitidis image
Blastomyces dermatitidis is the causal agent of blastomycosis, an invasive and often serious fungal infection found occasionally in humans and other animals in regions where the fungus is endemic The causal organism is a fungus living in soil and wet, decaying wood, often in an area close to a waterway such as a lake, river or stream Indoor growth may also occur, for example, in accumulated debris in damp sheds or shacks The fungus is endemic to parts of eastern North America, particularly boreal northern Ontario, southeastern Manitoba, Quebec south of the St Lawrence River, parts of the US Appalachian mountains and interconnected eastern mountain chains, the west bank of Lake Michigan, the state of Wisconsin, and the entire Mississippi Valley including the valleys of some major tributaries such as the Ohio River In addition, it occurs rarely in Africa both north and south of the Sahara Desert, as well as in the Arabian Peninsula and the Indian subcontinent Though it has never been directly observed growing in nature, it is thought to grow there as a cottony white mold, similar to the growth seen in artificial culture at 25 °C 77 °F In an infected human or animal, however, it converts in growth form and becomes a large-celled budding yeast Blastomycosis is generally readily treatable with systemic antifungal drugs once it is correctly diagnosed; however, delayed diagnosis is very common except in highly endemic areas


  • 1 Morphology and phylogeny
  • 2 Geographic distribution and variants
  • 3 Ecology
  • 4 Preventive measures
  • 5 References
  • 6 External links

Morphology and phylogeny

Blastomyces dermatitidis is the causal agent of blastomycosis, a potentially very serious disease that typically begins with a characteristically subtle pneumonia-like infection that may progress, after 1–6 months, to a disseminated phase that causes lesions to form in capillary beds throughout the body, most notably the skin, internal organs, central nervous system and bone marrow Blastomyces dermatitidis is the name applied to the ascomycetous fungus, Ajellomyces dermatitidis In 2013, a second species was described in the genus Blastomyces, B gilchristii, which subsumes certain strains previously assigned to B dermatitidis Despite widespread use, the genus Blastomyces is currently invalid under the International Code of Botanical Nomenclature Along with two other important human-pathogenic fungi, Histoplasma capsulatum, Paracoccidioides brasiliensis and Polytolypa hystricis, species of Blastomyces belong to a recently recognized fungal family, the Ajellomycetaceae The three principal pathogens in this family are all grouped physiologically as “dimorphic fungi”: fungi that switch from a mold-like filamentous growth form in the natural habitat to a yeast-like growth form in the warm-blooded animal host Blastomyces dermatitidis itself is a sexual organism, occurring in nature as both a + mating type and a − mating type This is epidemiologically important for two reasons: firstly, it implies that the organism will be genetically variable, potentially leading to variations in disease severity, treatment response and habitat preference; secondly, it implies that a suitable, stable habitat must exist for the complex process of sexual reproduction to take place This habitat is as yet unknown In its asexual form, the fungus grows as a typical colonial microfungus, comparable to Penicillium or Rhizopus mold forms commonly seen on mouldy bread

In nature, the fungus forms a network of thread-like mycelium that penetrates the substratum on which it grows, and then after 3–5 days of growth begins to reproduce asexually with small 2–10 µm conidia asexual spores These conidia are probably the main infectious particles produced by the fungus They form on individual short stalks and readily become airborne when the colony is disturbed; their size places them well within the respirable size range for particles, meaning that they can deposit deeply in the lungs when inhaled Sexual reproduction by the fungus requires the meeting of colonies of + and – mating type, probably a relatively rare event, and results in the production of small ascomata sexual fruiting bodies 200–350 µm, looking, to the naked eye, similar to a woollen fuzz ball, and in microscopic view consisting of a layer of spiralling, springy guard hairs surrounding a fertile core in which groups of 8 ascospores sexual spores are produced in small round reproductive sacs asci The ascospores, at 15–20 µm, are among the smallest reproductive particles produced by fungi, and are within the respirable size range The budding yeast cells seen in infected tissues and bodily fluids are generally relatively large ca 8–15 µm and characteristically bud through a broad base or neck, making them highly recognizable to the pathologist A small “nanic” form is rarely seen with cells under 6 µm

Geographic distribution and variants

One of the unexplained regularities of nature is that there are several fungi of different phylogenetic ancestry that show a similar pattern of existence: dimorphism conversion from a filamentous form in the environment to a yeast form in warm-blooded host tissues, virulent pathogenesis ability to cause a significant infection in an animal host that is otherwise in good health, pulmonary infectivity infection mainly via the lungs and sharply delimited endemism occurrence in only a limited geographic range Blastomyces dermatitidis is one of these fungi; the others are Histoplasma capsulatum, Paracoccidioides brasiliensis, Coccidioides immitis, C posadasii and Penicillium marneffei

The geographic range of B dermatitidis is largely focused around the waterways of the St Lawrence and Mississippi River systems of North America There is a widely distributed and much republished, partially erroneous map that shows the US portion of this range accurately, inclusive of occurrence in Minnesota, Wisconsin, Ohio, Kentucky, Arkansas, Tennessee, North and South Carolina, the Virginias, Mississippi, Louisiana, and a few regions of states adjacent to those named The Canadian range of B dermatitidis shows an abundance of blastomycosis in broad areas north and south of the St Lawrence River in Quebec, as well as high endemicity along the north shore of Lake Erie and the low endemicity in southeastern corner of Manitoba Though the Quebec distribution is reasonably accurate, the rest of Canada is strongly misrepresented Blastomyces dermatitidis is absent or nearly so from the Lake Erie area, but occurs sporadically on the north shore of Lake Ontario, including metropolitan Toronto, and, most notably, has areas of high endemicity throughout northern Ontario Remarkably high incidence is noted for some parts of the Kenora area and climatologically similar areas of northwestern Ontario To the west, the range of endemic blastomycosis extends across southern Manitoba and into adjacent Saskatchewan A few cases have been reported from north central Alberta, eg, the Edmonton area, though in these cases an atypical genetic group of the fungus may be involved

In the rest of the world, B dermatitidis occurs at low levels in various parts of Africa, from Algeria to South Africa, as well as in and near the Arabian Peninsula The African isolates are divided into two biologically different antigen groups: isolates from north of the Sahara are similar to North American isolates in having A and K antigens, while southern African isolates lack the A antigen Isolates from the middle east possess both antigens The sub-Saharan African isolates differ in the laboratory from other isolates by being exceedingly difficult to convert to the yeast phase, and they also show some enzymatic distinctions


Blastomyces dermatitidis is one of the most ecologically mysterious organisms causing human and animal disease Prediction of disease risk and prevention of disease are both made extraordinarily difficult by our very poor understanding of where and how this organism normally grows in nature Despite decades of attempts at isolating organisms from epidemiological foci, B dermatitidis has only been isolated from the environment 21 times Most of these isolations have been based on the arduous isolation techniques involving the suspension of soil or other environmental materials in aqueous medium with antibacterial antibiotics, and injection of mice with these materials, followed by sacrifice of the animals when they appear ill or at the end of six weeks The internal organs of the mice are then checked microscopically for evidence of blastomycosis Needless to say, the cost and complexity of performing such studies is imposing, especially as the ethical clearance procedures for work involving animals become ever more involved More direct and economical mycological techniques for environmental isolation, such as dilution plating, have never yielded positive results for Blastomyces growth Since B dermatitidis will grow readily from clinical samples on common laboratory media, the lack of success in isolating it from environmental materials is generally ascribed to the inhibitory effects of co-occurring common molds and antibiotic-resistant bacteria

In just one experiment, a single positive B dermatitidis culture was gained via use of a novel enrichment broth technique Recently, in an important breakthrough, a specific PCR technique was developed that was able to detect B dermatitidis in three environmental samples from a dog kennel that had been experiencing problems with blastomycosis

What has been learned from direct isolation and recent PCR studies is that B dermatitidis tends to be associated with soils and wood debris in areas “characterized by an acidic pH, high organic content due to rotting or decayed wood or vegetation and animal or bird droppings, abundant moisture, and proximity to waterways” Recent PCR detections, for example, concerned a Kentucky dog kennel where 35 of 100 dogs had contracted blastomycosis Previous isolations have been from comparable sites such as soil and wood debris from an abandoned Wisconsin beaver dam, and woody materials from a Wisconsin woodpile Isolation of B dermatitidis was also accomplished from an earthen floor indoors on one occasion

There has been a long history of justifiable speculation that B dermatitidis may associate in nature with one or more indigenous North American mammalian host species To date, however, all the animal species that have been subjected to focused investigation have been exonerated of this specific connection Unsubstantiated suspicion has particularly focused on the beaver, but the shrew, the bat and the prairie dog have also been focal points of interest, with no conclusive interspecies association being demonstrated to date Interestingly, the closely related pathogenic fungus P brasiliensis in South America has a well substantiated, though not well understood, ecological link with the nine-banded armadillo, Dasypus novemcinctus This member of the mammalian order Edentata has no close relatives in the geographic range of B dermatitidis

Preventive measures

Avoidance of exposure in endemic areas is the principal means of disease prevention Because the agent is known to distribute in dusts, the minimization of dust-generating activities, such as digging, sweeping, etc, is key Although a method of soil decontamination has been described and demonstrated to be effective, it uses hazardous chemicals and its use is best reserved for situations that cannot be managed otherwise


  1. ^ a b c DiSalvo, AF 1992 Al-Doory, Y; DiSalvo, AF, eds Ecology of Blastomyces dermatitidis Plenum pp 43–73 
  2. ^ Brown, Elizabeth M; McTaggart, Lisa R; Zhang, Sean X; Low, Donald E; Stevens, David A; Richardson, Susan E; Litvintseva, Anastasia P 22 March 2013 "Phylogenetic Analysis Reveals a Cryptic Species Blastomyces gilchristii, sp nov within the Human Pathogenic Fungus Blastomyces dermatitidis" PLoS ONE 8 3: e59237 Bibcode:2013PLoSO859237B doi:101371/journalpone0059237 PMC 3606480  PMID 23533607 
  3. ^ Peterson, SW; Sigler, L 1998 "Molecular genetic variation in Emmonsia crescens and Emmonsia parva, etiologic agents of adiaspiromycosis, and their phylogenetic relationship to Blastomyces dermatitidis Ajellomyces dermatitidis and other systemic fungal pathogens" Journal of Clinical Microbiology 36 10: 2918–25 PMID 9738044 
  4. ^ Untereiner, Wendy A; Scott, James A; Naveau, F; Sigler, Lynne; Bachewich, J; Angus, A 2004 "The Ajellomycetaceae, a new family of vertebrate-associated Onygenales" Mycologia 96 4: 812–21 doi:102307/3762114 JSTOR 3762114 PMID 21148901 
  5. ^ a b Lippman, M 2001 Size-selective health hazard sampling Pp In BS Cohen, CS McCammon eds, Air Sampling Instruments, 9th edition ACGIH Press, Cincinnati, Ohio Cincinnati, Ohio: in BS Cohen, CS McCammon eds, Air Sampling Instruments, 9th edition ACGIH Press pp 93–134 
  6. ^ Kwon-Chung, KJ, Bennett, JE; Bennett, John E 1992 Medical Mycology Philadelphia: Lea & Febiger ISBN 978-0812114638 
  7. ^ Lester, RS; DeKoven, JG; Kane, J; Simor, AE; Krajden, S; Summerbell, RC 2000 "Novel cases of blastomycosis acquired in Toronto, Ontario" Canadian Medical Association Journal 163 10: 1309–12 PMID 11107469 
  8. ^ Kane, J; Righter, J; Krajden, S; Lester, RS 1983 "Blastomycosis: a new endemic focus in Canada" Canadian Medical Association Journal 129 7: 728–31 PMID 6616383 
  9. ^ Dwight, PJ; Naus, M; Sarsfield, P; Limerick, B 2000 "An outbreak of human blastomycosis: the epidemiology of blastomycosis in the Kenora catchment region of Ontario, Canada" Canada Communicable Disease Report 26 10: 82–91 PMID 10893821 
  10. ^ Vallabh, V; Martin, T; Conly, JM 1988 "Blastomycosis in Saskatchewan" The Western journal of medicine 148 4: 460–2 PMID 3388850 
  11. ^ Sekhon, AS; Jackson, FL; Jacobs, HJ 1982 "Blastomycosis: report of the first case from Alberta Canada" Mycopathologia 79 2: 65–9 doi:101007/bf00468081 PMID 6813742 
  12. ^ Frean, JA; Carman, WF; Crewe-Brown, HH; Culligan, GA; Young, CN 1989 "Blastomyces dermatitidis infections in the RSA" South African Medical Journal = Suid-Afrikaanse tydskrif vir geneeskunde 76 1: 13–6 PMID 2662433 
  13. ^ Summerbell, RC; Kane, J; Pincus, DH 1990 "Enzymatic activity profiling as a potential biotyping method for Ajellomyces dermatitidis" Journal of Clinical Microbiology 28 5: 1054–6 PMC 267864  PMID 2351722 
  14. ^ a b c Burgess, JW; Schwan, WR; Volk, TJ 2006 "PCR-based detection of DNA from the human pathogen Blastomyces dermatitidis from natural soil samples" Medical Mycology 44 8: 741–8 doi:101080/13693780600954749 PMID 17127631 
  15. ^ a b Ajello, L, and R J Weeks 1983 Soil decontamination and other control measures Pp 229-238 In A F DiSalvo ed, Occupational Mycoses Lea and Febiger, Philadelphia, Pennsylvania
  16. ^ a b Baumgardner, DJ; Paretsky, DP 1999 "The in vitro isolation of Blastomyces dermatitidis from a woodpile in north central Wisconsin, USA" Medical Mycology 37 3: 163–8 doi:101111/j1365-280x199900214x PMID 10421847 
  17. ^ Baumgardner, DJ; Buggy, BP; Mattson, BJ; Burdick, JS; Ludwig, D 1992 "Epidemiology of blastomycosis in a region of high endemicity in north central Wisconsin" Clinical Infectious Diseases 15 4: 629–35 doi:101093/clind/154629 PMID 1420675 
  18. ^ a b Klein, Bruce S; Vergeront, James M; Weeks, Robert J; Kumar, U Nanda; Mathai, George; Varkey, Basil; Kaufman, Leo; Bradsher, Robert W; Stoebig, James F; Davis, Jeffrey P 1986 "Isolation of Blastomyces dermatitidis in soil associated with a large outbreak of blastomycosis in Wisconsin" New England Journal of Medicine 314 9: 529–534 doi:101056/NEJM198602273140901 PMID 3945290 
  19. ^ Bakerspigel, A; Kane, J; Schaus, D 1986 "Isolation of Blastomyces dermatitidis from an earthen floor in southwestern Ontario, Canada" Journal of Clinical Microbiology 24 5: 890–1 PMID 3771778 
  20. ^ Bradsher, RW 1987 "Water and blastomycosis: don't blame beaver" The American Review of Respiratory Disease 136 6: 1324–6 doi:101164/ajrccm/13661324 PMID 3688633 
  21. ^ Gaus, DP; Baumgardner, DJ; Paretsky, D 1996 "Attempted isolation of Blastomyces dermatitidis from rectal cultures of beaver Castor canadensis from north central Wisconsin" Wilderness & Environmental Medicine 7 2: 192 doi:101580/1080-6032199600723co;2 PMID 11990111 
  22. ^ Baumgardner, DJ; Summerbell, R; Krajden, S; Alexopoulou, I; Agrawal, B; Bergeson, M; Fuksa, M; Bemis, C; Baumgardner, MA 2005 "Attempted isolation of Blastomyces dermatitidis from native shrews in northern Wisconsin, USA" Medical Mycology 43 5: 413–6 doi:101080/13693780400008191 PMID 16178369 
  23. ^ Chaturvedi, VP; Randhawa, HS; Kini, S; Khan, ZU 1986 "Survival of Blastomyces dermatitidis in the gastrointestinal tract of an orally infected insectivorous bat, Rhinopoma hardwickei hardwickei Gray" Journal of Medical and Veterinary Mycology 24 4: 349–52 doi:101080/02681218680000521 PMID 3746588 
  24. ^ De Groote, MA; Bjerke, R; Smith, H; Rhodes III, LV 2000 "Expanding epidemiology of blastomycosis: clinical features and investigation of 2 cases in Colorado" Clinical Infectious Diseases 30 3: 582–4 doi:101086/313717 PMID 10722448 
  25. ^ Vergara, ML; Martinez, R 1999 "Role of the armadillo Dasypus novemcinctus in the epidemiology of paracoccidioidomycosis" Mycopathologia 144 3: 131–3 doi:101023/A:1007034215003 PMID 10531678 

External links

  • Blastomyces at the US National Library of Medicine Medical Subject Headings MeSH
  • "Blastomyces dermatitidis" Mycology Online § Dimorphic Fungal Pathogens University of Adelaide 
  • http://pathmicromedscedu/mycology/mycology-6htm

blastomyces dermatitidis, blastomyces dermatitidis fungus, blastomyces dermatitidis gram stain, blastomyces dermatitidis image, blastomyces dermatitidis in dogs, blastomyces dermatitidis morphology, blastomyces dermatitidis skin lesions, blastomyces dermatitidis symptoms, blastomyces dermatitidis treatment, blastomyces dermatitidis yeast phase

Blastomyces dermatitidis Information about

Blastomyces dermatitidis

  • user icon

    Blastomyces dermatitidis beatiful post thanks!


Blastomyces dermatitidis
Blastomyces dermatitidis
Blastomyces dermatitidis viewing the topic.
Blastomyces dermatitidis what, Blastomyces dermatitidis who, Blastomyces dermatitidis explanation

There are excerpts from wikipedia on this article and video

Random Posts

Amorphous metal

Amorphous metal

An amorphous metal also known as metallic glass or glassy metal is a solid metallic material, usuall...
Arthur Lake (bishop)

Arthur Lake (bishop)

Arthur Lake September 1569 – 4 May 1626 was Bishop of Bath and Wells and a translator of the King Ja...
John Hawkins (author)

John Hawkins (author)

Sir John Hawkins 29 March 1719 – 21 May 1789 was an English author and friend of Dr Samuel Johnson a...
McDonnell Douglas MD-12

McDonnell Douglas MD-12

The McDonnell Douglas MD-12 was an aircraft design study undertaken by the McDonnell Douglas company...