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Benzathine benzylpenicillin

benzathine benzylpenicillin, benzathine benzylpenicillin for injection
Benzathine benzylpenicillin, also known as benzathine penicillin G, is an antibiotic useful for the treatment of a number of bacterial infections Specifically it is to treat strep throat, diphtheria, syphilis, and yaws It is also used to prevent rheumatic fever It is given by injection into a muscle

Side effects include allergic reactions including anaphylaxis, and pain at the site of injection When used to treat syphilis a reaction known as Jarisch-Herxheimer may occur It is not recommended in those with a history of penicillin allergy or those with syphilis involving the nervous system Use during pregnancy is generally safe It is in the penicillin and beta lactam class of medications and works via benzylpenicillin The benzathine component slowly releases the penicillin making the combination long acting

Benzathine benzylpenicillin was patented in 1950 It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system The wholesale cost in the developing world is about 027 to 171 USD for a course of treatment In the United States the medication costs 50 to 100 USD for a dose as of 2015 In the United Kingdom it costs the NHS about 095 to 189 pounds a dose as of 2015


  • 1 Adverse effects
  • 2 Mechanism of action
  • 3 Society and culture
  • 4 Compendial status
  • 5 References

Adverse effects

2,400,000 units of Bicillin L-A brand of benzylpenicillin, for deep intramuscular injectionFurther information:Penicillin drug reaction

Mechanism of action

It is in the penicillin class of medications It is slowly absorbed into the circulation, after intramuscular injection, and hydrolysed to benzylpenicillin in vivo It is the drug-of-choice when prolonged low concentrations of benzylpenicillin are required and appropriate, allowing prolonged antibiotic action over 2–4 weeks after a single IM dose

Society and culture

It is marketed by Pfizer formerly by Wyeth under the trade name Bicillin L-A

Compendial status

  • British Pharmacopoeia


  1. ^ a b c d e f "Penicillin G Benzathine Professional Patient Advice - Drugscom" wwwdrugscom Archived from the original on 20 December 2016 Retrieved 10 December 2016 
  2. ^ a b Hamilton, Richart 2015 Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition Jones & Bartlett Learning p 94 ISBN 9781284057560 
  3. ^ a b Engel, Jürgen; Kleemann, Axel; Kutscher, Bernhard; Reichert, Dietmar 2014 Pharmaceutical Substances, 5th Edition, 2009:Syntheses, Patents and Applications of the most relevant APIs 5 ed Georg Thieme Verlag p 134 ISBN 9783131792754 Archived from the original on 20 December 2016 
  4. ^ a b c d e f g WHO Model Formulary 2008 PDF World Health Organization 2009 pp 98, 104 ISBN 9789241547659 Archived PDF from the original on 13 December 2016 Retrieved 8 December 2016 
  5. ^ Ebadi, Manuchair 2007 Desk Reference of Clinical Pharmacology, Second Edition 2 ed CRC Press p 555 ISBN 9781420047448 Archived from the original on 20 December 2016 
  6. ^ "WHO Model List of Essential Medicines 19th List" PDF World Health Organization April 2015 Archived PDF from the original on 13 December 2016 Retrieved 8 December 2016 
  7. ^ "Penicillin, Benzathine Benzyl" International Drug Price Indicator Guide Retrieved 8 December 2016 
  8. ^ British national formulary :BNF 69 69 ed British Medical Association 2015 p 367 ISBN 9780857111562 
  9. ^ British Pharmacopoeia Commission Secretariat "Index BP 2009" PDF Archived from the original PDF on 11 April 2009 Retrieved 26 March 2010 
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Benzathine benzylpenicillin

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