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Basophilia

basophilia, basophilia of cytoplasm
Basophilia is a condition derived from Basophils It is characterized by an abnormal abundance more than 1010 10 billion basophils per liter of blood of Basophils in the bloodstream[1] Basophilia is associated with pruritus itching due to the release of histamine[2]

Contents

  • 1 Signs and Symptoms
  • 2 Causes
  • 3 Physiology
  • 4 Diagnosis
  • 5 Treatment
  • 6 Animals
  • 7 References
  • 8 External links

Signs and Symptoms

  • Signs and Symptoms for Allergies[3]:
    • Sneezing
    • Runny Nose/ Stuff Nose
    • Hives
    • Rash
    • Swelling of the mouth and throat
    • Nausea/ Vomiting
    • Trouble Breathing
    • Itchy
  • Signs and Symptoms for Inflammation[4]:
    • Coughing
    • Fever
    • Fatigue
    • Headache
    • Loss of appetite/ Change in appetite
  • Signs and Symptoms for Myeloproliferative Disorders[5]:
    • Fatigue
    • Weakness
    • Fever
    • Unexplained weight loss
    • Easy bleeding/ bruising
    • Bloating
    • Bone Pain
    • Abdominal Pain
    • Changes in vision/ Blurred vision

Causes

Generally linked to allergic/hypersensitivity disorders or chronic inflammatory conditions

Blood Smear

These conditions can include:

  • Allergy or inflammation
  1. Ulcerative colitis
  2. Drug, food, inhalant hypersensitivity
  3. Erythroderma, urticaria
  4. Juvenile rheumatoid arthritis
  5. Hay Fever
  • Endocrinopathy
  1. Diabetes mellitus
  2. Estrogen administration
  • Inflammation
    1. Rheumatoid Arthritis
    2. Hypothyroidism
    3. Psoriosis
  • Infection
  1. Chicken pox
  2. Influenza
  3. Smallpox
  4. Tuberculosis
  • Iron deficiency
  • Exposure to ionizing radiation
  • Neoplasia
  1. "Basophilic leukemia" see text
  • Myeloproliferative neoplasms especially chronic myelogenous leukemia; also polycythemia vera, primary myelofibrosis, essential thrombocythemia
  • Carcinoma

Physiology

Basophil is a type of Granulocyte, White Blood Cell/ Leukocyte WBCs that provides immunity and defense for our bodies from viruses, bacteria, and foreign objects It is associated to interleukin IL-3, IL-5, and granulocyte-monocyte-colony stimulating factor GM-CSF[6] through a release of synthesis-storing Histamine and Heparin that occupies about 05-1% of the circulating WBCs Can also be characterized by an unsegmented/ bilobed shaped nucleus with purplish-black/ deep blue cytoplasmic granules It averages about 8-10 micrometer

Diagnosis

Basophilia can be detected through a complete blood count CBC to determine if there is an abnormal amount in the bloodstream more than 10 billion basophils per liter of blood

Basophilia can also by diagnosed through a bone marrow biopsy, genetic testing to look for genetic mutations, or ultrasound to determine enlargement of the spleen

Treatment

Basophilia is not likely to be treated directly Instead, treatments will focus on the person’s underlying medical treatment

Treatments for underlying medical conditions include:

  • Medications
  • Chemotherapy/ Radiation
  • Surgery to remove enlarged spleen

Animals

Eosinophilia and Basophilia are the most common abnormalities in dogs[7]

References

  1. ^ "Cytoplasmic basophilia" Veterinary Clinical Pathology Image Database University of Montreal Veterinary College Retrieved 2008-09-20 
  2. ^ Interactive, Wellfire "Pathology Thread" wwwmed-edvirginiaedu Retrieved 2016-04-07 
  3. ^ "Basophilia: Definition, Symptoms, and Causes" Healthline Retrieved 2018-05-10 
  4. ^ "Basophilia: Definition, Symptoms, and Causes" Healthline Retrieved 2018-05-10 
  5. ^ "Basophilia: Definition, Symptoms, and Causes" Healthline Retrieved 2018-05-10 
  6. ^ Themes, UFO 2016-06-13 "Basophilia" Basicmedical Key Retrieved 2018-05-10 
  7. ^ "Basophilia - an overview | ScienceDirect Topics" wwwsciencedirectcom Retrieved 2018-05-10 

External links

Classification D
  • ICD-10: D72824
  • DiseasesDB: 65209002

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    Basophilia beatiful post thanks!

    29.10.2014


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