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AXL receptor tyrosine kinase

axl receptor tyrosine kinase
2C5D, 4RA0

Identifiers Aliases AXL, AZF, AZFA, SP3, AZF1, ARK, JTK11, Tyro7, UFO, AXL receptor tyrosine kinase External IDs MGI: 1347244 HomoloGene: 7583 GeneCards: AXL RNA expression pattern

More reference expression data Orthologs Species Human Mouse Entrez
Ensembl
UniProt
RefSeq mRNA

NM_001278599
NM_001699
NM_021913

NM_001190974
NM_001190975
NM_009465

RefSeq protein

NP_001265528
NP_001690
NP_068713

NP_001177903
NP_001177904
NP_033491

Location UCSC Chr 19: 4122 – 4126 Mb Chr 7: 2576 – 2579 Mb PubMed search 1 2 Wikidata
^ "Mouse PubMed Reference:" 
  • ^ O'Bryan JP, Frye RA, Cogswell PC, Neubauer A, Kitch B, Prokop C, Espinosa R, Le Beau MM, Earp HS, Liu ET Oct 1991 "axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase" Molecular and Cellular Biology 11 10: 5016–31 PMC 361494  PMID 1656220 
  • ^ a b c d e "Entrez Gene: AXL AXL receptor tyrosine kinase" 
  • ^ Janssen JW, Schulz AS, Steenvoorden AC, Schmidberger M, Strehl S, Ambros PF, Bartram CR 1991 "A novel putative tyrosine kinase receptor with oncogenic potential" Oncogene 6 11: 2113–20 PMID 1834974 
  • ^ a b c d Wu X, Liu X, Koul S, Lee CY, Zhang Z, Halmos B 2014 "AXL kinase as a novel target for cancer therapy" Oncotarget 5 20: 9546–63 PMC 4259419  PMID 25337673 doi:1018632/oncotarget2542 
  • ^ Vajkoczy P, Knyazev P, Kunkel A, Capelle HH, Behrndt S, von Tengg-Kobligk H, Kiessling F, Eichelsbacher U, Essig M, Read TA, Erber R, Ullrich A Apr 2006 "Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival" Proceedings of the National Academy of Sciences of the United States of America 103 15: 5799–804 PMC 1458653  PMID 16585512 doi:101073/pnas0510923103 
  • ^ Nowakowski TJ, Pollen AA, Di Lullo E, Sandoval-Espinosa C, Bershteyn M, Kriegstein AR 2016 "Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor in Neural Stem Cells" Cell Stem Cell 18 5: 591–596 ISSN 1934-5909 PMID 27038591 doi:101016/jstem201603012 
  • ^ Gilteritinib Granted Orphan Drug Status for Acute Myeloid Leukemia 2017
  • ^ 1
  • ^ Multicenter Open-label Study of BGB324 as a Single Agent and in Combination With Cytarabine in Patients With AML
  • ^ A Study of BGB324 in Combination With Erlotinib in Patients With Non-Small Cell Lung Cancer
  • ^ Hafizi S, Alindri F, Karlsson R, Dahlbäck B Dec 2002 "Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin" Biochemical and Biophysical Research Communications 299 5: 793–800 PMID 12470648 doi:101016/S0006-291X0202718-3 
  • Further readingedit

    • Neubauer A, Burchert A, Maiwald C, Gruss HJ, Serke S, Huhn D, Wittig B, Liu E Mar 1997 "Recent progress on the role of Axl, a receptor tyrosine kinase, in malignant transformation of myeloid leukemias" Leukemia & Lymphoma 25 1-2: 91–6 PMID 9130617 doi:103109/10428199709042499 
    • Bergsagel PL, Victor-Kobrin C, Timblin CR, Trepel J, Kuehl WM Jan 1992 "A murine cDNA encodes a pan-epithelial glycoprotein that is also expressed on plasma cells" Journal of Immunology 148 2: 590–6 PMID 1729376 
    • Partanen J, Mäkelä TP, Alitalo R, Lehväslaiho H, Alitalo K Nov 1990 "Putative tyrosine kinases expressed in K-562 human leukemia cells" Proceedings of the National Academy of Sciences of the United States of America 87 22: 8913–7 PMC 55070  PMID 2247464 doi:101073/pnas87228913 
    • Neubauer A, Fiebeler A, Graham DK, O'Bryan JP, Schmidt CA, Barckow P, Serke S, Siegert W, Snodgrass HR, Huhn D Sep 1994 "Expression of axl, a transforming receptor tyrosine kinase, in normal and malignant hematopoiesis" Blood 84 6: 1931–41 PMID 7521695 
    • O'Bryan JP, Fridell YW, Koski R, Varnum B, Liu ET Jan 1995 "The transforming receptor tyrosine kinase, Axl, is post-translationally regulated by proteolytic cleavage" The Journal of Biological Chemistry 270 2: 551–7 PMID 7822279 doi:101074/jbc2702551 
    • Lee ST, Strunk KM, Spritz RA Dec 1993 "A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes" Oncogene 8 12: 3403–10 PMID 8247543 
    • Schulz AS, Schleithoff L, Faust M, Bartram CR, Janssen JW Feb 1993 "The genomic structure of the human UFO receptor" Oncogene 8 2: 509–13 PMID 8381225 
    • O'Bryan JP, Songyang Z, Cantley L, Der CJ, Pawson T Apr 1996 "A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain" Proceedings of the National Academy of Sciences of the United States of America 93 7: 2729–34 PMC 39699  PMID 8610109 doi:101073/pnas9372729 
    • Mark MR, Chen J, Hammonds RG, Sadick M, Godowsk PJ Apr 1996 "Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl" The Journal of Biological Chemistry 271 16: 9785–9 PMID 8621659 doi:101074/jbc271169785 
    • Braunger J, Schleithoff L, Schulz AS, Kessler H, Lammers R, Ullrich A, Bartram CR, Janssen JW Jun 1997 "Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site" Oncogene 14 22: 2619–31 PMID 9178760 doi:101038/sjonc1201123 
    • Tanaka K, Nagayama Y, Nakano T, Takamura N, Namba H, Fukada S, Kuma K, Yamashita S, Niwa M Mar 1998 "Expression profile of receptor-type protein tyrosine kinase genes in the human thyroid" Endocrinology 139 3: 852–8 PMID 9492013 doi:101210/en1393852 
    • Yanagita M, Arai H, Ishii K, Nakano T, Ohashi K, Mizuno K, Varnum B, Fukatsu A, Doi T, Kita T Apr 2001 "Gas6 regulates mesangial cell proliferation through Axl in experimental glomerulonephritis" The American Journal of Pathology 158 4: 1423–32 PMC 1891897  PMID 11290560 doi:101016/S0002-94401064093-X 
    • Sun WS, Misao R, Iwagaki S, Fujimoto J, Tamaya T Jun 2002 "Coexpression of growth arrest-specific gene 6 and receptor tyrosine kinases, Axl and Sky, in human uterine endometrium and ovarian endometriosis" Molecular Human Reproduction 8 6: 552–8 PMID 12029073 doi:101093/molehr/86552 
    • D'Arcangelo D, Gaetano C, Capogrossi MC Oct 2002 "Acidification prevents endothelial cell apoptosis by Axl activation" Circulation Research 91 7: e4–12 PMID 12364394 doi:101161/01RES000003675350601E9 
    • Hafizi S, Alindri F, Karlsson R, Dahlbäck B Dec 2002 "Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin" Biochemical and Biophysical Research Communications 299 5: 793–800 PMID 12470648 doi:101016/S0006-291X0202718-3 
    • Ito M, Nakashima M, Nakayama T, Ohtsuru A, Nagayama Y, Takamura N, Demedchik EP, Sekine I, Yamashita S Nov 2002 "Expression of receptor-type tyrosine kinase, Axl, and its ligand, Gas6, in pediatric thyroid carcinomas around chernobyl" Thyroid 12 11: 971–5 PMID 12490074 doi:101089/105072502320908303 

    External linksedit

    • Human AXL genome location and AXL gene details page in the UCSC Genome Browser
    • Molecular and Cellular Biology portal

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      AXL receptor tyrosine kinase beatiful post thanks!

      29.10.2014


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