Anti-sp100 antibodiesanti sp 100 antibodies in blood, anti sp 100 antibodies definition
Anti-sp100 antibodies are found in association with primary biliary cirrhosis The autoimmune target of anti-sp100 is the sp100 nuclear antigen which was identified by its association with primary biliary cirrhosis 20-30% of patients suffering from primary biliary cirrhosis have sp100 Abs The sera of these patients exhibit a characteristic "nuclear dots" pattern in indirect immunofluorescence IIF on Hep-2 cells
Immunodominant regions of sp100
- Antigenic region 1 - positions 296-311 - Sequence I K K E K P F S N S K V E C Q A
- Antigenic region 2 - positions 332-351 - Sequence E G S T D V D E P L E V F I S A P R S E
Bolded areas represent the core epitope
- ^ Szostecki C, Guldner HH, Netter HJ, Will H 1990 "Isolation and characterization of cDNA encoding a human nuclear antigen predominantly recognized by autoantibodies from patients with primary biliary cirrhosis" J Immunol 145 12: 4338–47 PMID 2258622
- ^ Blüthner M, Schäfer C, Schneider C, Bautz FA 1999 "Identification of major linear epitopes on the sp100 nuclear PBC autoantigen by the gene-fragment phage-display technology" Autoimmunity 29 1: 33–42 doi:103109/08916939908995970 PMID 10052683
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