Sat . 20 Jul 2020
TR | RU | UK | KK | BE |

Anti-mitochondrial antibody

anti-mitochondrial antibody, anti-mitochondrial antibody and anti-smooth muscle antibody
Anti-mitochondrial antibodies AMA are autoantibodies, consisting of immunoglobulins formed against mitochondria, primarily the mitochondria in cells of the liver

The presence of AMA in the blood or serum of a person may be indicative of the presence of, or the potential to develop, the autoimmune disease primary biliary cirrhosis PBC; also known as primary biliary cholangitis PBC causes scarring of liver tissue, confined primarily to the bile duct drainage system AMA is present in about 95% of cases PBC is seen primarily in middle-aged women, and in those afflicted with other autoimmune diseases

Immunofluorescence staining pattern of AMA shown on stomach top left, liver top right, kidney bottom left and hep-20-10 cells bottom right


  • 1 Antigens
  • 2 Disease associations
  • 3 Development
  • 4 See also
  • 5 References


Several of the antigens associated with anti-mitochondrial antibodies have been identified

  • M1 – cardiolipin
  • M2 – branched-chain alpha-keto acid dehydrogenase complex
  • M3 – outer mitochondrial membrane
  • M4 – sulfite oxidase
  • M5 – outer mitochondrial membrane
  • M6 – outer mitochondrial membrane
  • M7 – sarcosine dehydrogenase
  • M8 – outer mitochondrial membrane
  • M9 – glycogen phosphorylase

Disease associations

Antibodies to these specific antigens have been associated with a number of conditions: anti M2, M4, M8, and M9 are associated with primary bilary cirrhosis; M2 – autoimmune hepatitis; M1 – syphilis; M3 – drug-induced lupus erythematosus; M6 – drug-induced hepatitis; M7 – cardiomyopathy, myocarditis; M5 – systemic lupus erythematosus and undifferentiated collagenosis, autoimmune haemolytic anaemia These associations are not completely specific and should not be relied upon solely for diagnosis

Antimitochondrial antibodies can also be detected in Sjögren's syndrome, systemic sclerosis, asymptomatic recurrent bacteriuria in women, pulmonary tuberculosis, and leprosy

Anti-cardiolipin antibodies are another type of AMA, and cardiolipin is found on the inner mitochondrial membrane


A cause of AMA has been postulated to be that xenobiotic-induced and/or oxidative modification of mitochondrial autoantigens is a critical step leading to loss of tolerance In acute liver failure AMA are found against all major liver antigens

  • Pyruvate dehydrogenase, E2 subunits
  • 2-Oxo-glutarate dehydrogenase
  • Branched-chain 2-oxo-acid dehydrogenase

Around 40% of acute liver failure patients were found to have elevated AMA, although a larger proportion 57% had anti-transglutaminase antibodies, usually associated with coeliac disease

See also

  • Antibodies
  • Mitochondrion


  1. ^ MedlinePlus Encyclopedia 003529
  2. ^ Oertelt S, Rieger R, Selmi C, Invernizzi P, Ansari A, Coppel R, Podda M, Leung P, Gershwin M 2007 "A sensitive bead assay for antimitochondrial antibodies: Chipping away at AMA-negative primary biliary cirrhosis" Hepatology 45 3: 659–65 doi:101002/hep21583 PMID 17326160 
  3. ^ Berg PA, Klein R 1992 Antimitochondrial antibodies in primary biliary cirrhosis and other disorders: definition and clinical relevance Dig Dis 102:85-101
  4. ^ a b Berg PA, Klein R 1986 Mitochondrial antigens and autoantibodies: from anti-M1 to anti-M9 Klin Wochenschr 6419:897-909
  5. ^ Labro MT, Andrieu MC, Weber M, Homberg JC 1976 A new pattern of non-organ- and non-species-specific anti-organelle antibody detected by immunofluorescence: the mitochondrial antibody number 5 Clin Exp Immunol 313:357-366
  6. ^ a b Leung PS, Rossaro L, Davis PA, et al 2007 "Antimitochondrial antibodies in acute liver failure: Implications for primary biliary cirrhosis" Hepatology 46 5: 1436–42 doi:101002/hep21828 PMC 3731127  PMID 17657817 

anti mitochondrial antibody diagnosis for, anti mitochondrial antibody liver, anti mitochondrial antibody test quest, anti mitochondrial antibody test results, anti-mitochondrial antibody, anti-mitochondrial antibody (ama), anti-mitochondrial antibody (ama) blood test, anti-mitochondrial antibody and anti-smooth muscle antibody, anti-mitochondrial antibody negative, anti-mitochondrial antibody titer

Anti-mitochondrial antibody Information about

Anti-mitochondrial antibody

  • user icon

    Anti-mitochondrial antibody beatiful post thanks!


Anti-mitochondrial antibody
Anti-mitochondrial antibody
Anti-mitochondrial antibody viewing the topic.
Anti-mitochondrial antibody what, Anti-mitochondrial antibody who, Anti-mitochondrial antibody explanation

There are excerpts from wikipedia on this article and video

Random Posts

La Porte, Indiana

La Porte, Indiana

La Porte French for "The Door" is a city in LaPorte County, Indiana, United States, of which it is t...
Fernando Montes de Oca Fencing Hall

Fernando Montes de Oca Fencing Hall

The Fernando Montes de Oca Fencing Hall is an indoor sports venue located in the Magdalena Mixhuca S...
My Everything (The Grace song)

My Everything (The Grace song)

"My Everything" was Grace's 3rd single under the SM Entertainment, released on November 6, 2006 Unli...
Turkish Straits

Turkish Straits

The Turkish Straits Turkish: Türk Boğazları are a series of internationally significant waterways in...