Anti-centromere antibodiesanti centromere antibodies, ana and anti-centromere antibodies positive
Anti-centromere antibodies ACAs; often styled solid, anticentromere are autoantibodies specific to centromere and kinetochore function They occur in some autoimmune diseases, frequently in limited systemic scleroderma formerly called CREST syndrome, and occasionally in the diffuse form of scleroderma They are rare in other rheumatic conditions and in healthy persons
Anti-centromere antibodies are found in approximately 60% of patients with limited systemic scleroderma and in 15% of those with the diffuse form of scleroderma The specificity of this test is >98% Thus, a positive anti-centromere antibody finding is strongly suggestive of limited systemic scleroderma Anti-centromere antibodies present early in the course of disease and are notably predictive of limited cutaneous involvement and a decreased likelihood of aggressive internal organ involvement, such as fibrosis in the lungs
When present in primary biliary cirrhosis, ACAs are prognostic of portal hypertension such that serum ACA levels correlate with the severity of portal hypertension
- ^ JB Imboden, DB Hellmann, JH Stone Current Rheumatology Diagnosis & Treatment, Second Edition McGraw-Hill, 2007
- ^ Nakamura M, Kondo H, Mori T, et al 2007 "Anti-gp210 and anti-centromere antibodies are different risk factors for the progression of primary biliary cirrhosis" Hepatology 45 1: 118–27 doi:101002/hep21472 PMID 17187436
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