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Annexin A1

annex in a1, annex in a1 endocytosis egf
1QLS, 1AIN, 1BO9

Identifiers Aliases ANXA1, ANX1, LPC1, annexin A1 External IDs OMIM: 151690 MGI: 96819 HomoloGene: 563 GeneCards: ANXA1
Gene location Human
Chr Chromosome 9 human
Band 9q2113 Start 73,151,757 bp
End 73,170,393 bp
RNA expression pattern
More reference expression data
Orthologs Species Human Mouse Entrez
RefSeq mRNA



RefSeq protein



Location UCSC Chr 9: 7315 – 7317 Mb Chr 19: 2037 – 2039 Mb PubMed search Wikidata
^ "Mouse PubMed Reference:" 
  • ^ Wallner BP, Mattaliano RJ, Hession C, Cate RL, Tizard R, Sinclair LK, Foeller C, Chow EP, Browing JL, Ramachandran KL 1986 "Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity" Nature 320 6057: 77–81 doi:101038/320077a0 PMID 2936963 
  • ^ a b "Entrez Gene: ANXA1 annexin A1" 
  • ^ Rhen T, Cidlowski JA October 2005 "Antiinflammatory action of glucocorticoids--new mechanisms for old drugs" N Engl J Med 353 16: 1711–23 doi:101056/NEJMra050541 PMID 16236742 
  • ^ a b c Perretti M, D'Acquisto F January 2009 "Annexin A1 and glucocorticoids as effectors of the resolution of inflammation" Nat Rev Immunol 9 1: 62–70 doi:101038/nri2470 PMID 19104500 
  • ^ Goppelt-Struebe M, Wolter D, Resch K December 1989 "Glucocorticoids inhibit prostaglandin synthesis not only at the level of phospholipase A2 but also at the level of cyclo-oxygenase/PGE isomerase" Br J Pharmacol 98 4: 1287–95 doi:101111/j1476-53811989tb12676x PMC 1854794  PMID 2514948 
  • ^ Peers SH, Smillie F, Elderfield AJ, Flower RJ January 1993 "Glucocorticoid-and non-glucocorticoid induction of lipocortins annexins 1 and 2 in rat peritoneal leucocytes in vivo" British Journal of Pharmacology 108 1: 66–72 doi:101111/j1476-53811993tb13441x PMC 1907693  PMID 8428216 
  • ^ Zhang Z, Huang L, Zhao W, Rigas B March 2010 "Annexin 1 induced by anti-inflammatory drugs binds to NF-kappaB and inhibits its activation: anticancer effects in vitro and in vivo" Cancer Res 70 6: 2379–88 doi:101158/0008-5472CAN-09-4204 PMC 2953961  PMID 20215502 
  • ^ Falini B, Tiacci E, Liso A, Basso K, Sabattini E, Pacini R, Foa R, Pulsoni A, Dalla Favera R, Pileri S June 2004 "Simple diagnostic assay for hairy cell leukaemia by immunocytochemical detection of annexin A1 ANXA1" Lancet 363 9424: 1869–70 doi:101016/S0140-67360416356-3 PMID 15183626 
  • ^ Tu Y, Johnstone CN, Stewart AG 2017 "Annexin A1 influences in breast cancer: Controversies on contributions to tumour, host and immunoediting processes" Pharmacological Research 119: 278–288 doi:101016/jphrs201702011 PMID 28212890 
  • ^ Ang EZ, Nguyen HT, Sim HL, Putti TC, Lim LH February 2009 "Annexin-1 regulates growth arrest induced by high levels of estrogen in MCF-7 breast cancer cells" Molecular Cancer Research 7 2: 266–74 doi:101158/1541-7786MCR-08-0147 PMID 19208747 
  • ^ Nair S, Hande MP, Lim LH August 2010 "Annexin-1 protects MCF7 breast cancer cells against heat-induced growth arrest and DNA damage" Cancer Letters 294 1: 111–7 doi:101016/jcanlet201001026 PMID 20163912 
  • ^ Berns K, Sonnenblick A, Gennissen A, Brohée S, Hijmans EM, Evers B, Fumagalli D, Desmedt C, Loibl S, Denkert C, Neven P, Guo W, Zhang F, Knijnenburg TA, Bosse T, van der Heijden MS, Hindriksen S, Nijkamp W, Wessels LF, Joensuu H, Mills GB, Beijersbergen RL, Sotiriou C, Bernards R November 2016 "Loss of ARID1A Activates ANXA1, which Serves as a Predictive Biomarker for Trastuzumab Resistance" Clinical Cancer Research 22 21: 5238–5248 doi:101158/1078-0432CCR-15-2996 PMID 27172896 
  • ^ Sonnenblick A, Brohée S, Fumagalli D, Rothé F, Vincent D, Ignatiadis M, Desmedt C, Salgado R, Sirtaine N, Loi S, Neven P, Loibl S, Denkert C, Joensuu H, Piccart M, Sotiriou C October 2015 "Integrative proteomic and gene expression analysis identify potential biomarkers for adjuvant trastuzumab resistance: analysis from the Fin-her phase III randomized trial" Oncotarget 6 30: 30306–16 doi:1018632/oncotarget5080 PMC 4745800  PMID 26358523 
  • Further reading

    • Crompton MR, Moss SE, Crumpton MJ 1988 "Diversity in the lipocortin/calpactin family" Cell 55 1: 1–3 doi:101016/0092-86748890002-5 PMID 2971450 
    • Lim LH, Pervaiz S 2007 "Annexin 1: the new face of an old molecule" FASEB J 21 4: 968–75 doi:101096/fj06-7464rev PMID 17215481 
    • Dawson SJ, White LA 1992 "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin" J Infect 24 3: 317–20 doi:101016/S0163-44530580037-4 PMID 1602151 
    • Ando Y, Imamura S, Owada MK, Kannagi R 1991 "Calcium-induced intracellular cross-linking of lipocortin I by tissue transglutaminase in A431 cells Augmentation by membrane phospholipids" J Biol Chem 266 2: 1101–8 PMID 1670773 
    • Kovacic RT, Tizard R, Cate RL, et al 1991 "Correlation of gene and protein structure of rat and human lipocortin I" Biochemistry 30 37: 9015–21 doi:101021/bi00101a015 PMID 1832554 
    • Varticovski L, Chahwala SB, Whitman M, et al 1988 "Location of sites in human lipocortin I that are phosphorylated by protein tyrosine kinases and protein kinases A and C" Biochemistry 27 10: 3682–90 doi:101021/bi00410a024 PMID 2457390 
    • Pepinsky RB, Sinclair LK, Chow EP, O'Brine-Greco B 1990 "A dimeric form of lipocortin-1 in human placenta" Biochem J 263 1: 97–103 PMC 1133395  PMID 2532504 
    • Kaplan R, Jaye M, Burgess WH, et al 1988 "Cloning and expression of cDNA for human endonexin II, a Ca2+ and phospholipid binding protein" J Biol Chem 263 17: 8037–43 PMID 2967291 
    • Huebner K, Cannizzaro LA, Frey AZ, et al 1988 "Chromosomal localization of the human genes for lipocortin I and lipocortin II" Oncogene Res 2 4: 299–310 PMID 2969496 
    • Biemann K, Scoble HA 1987 "Characterization by tandem mass spectrometry of structural modifications in proteins" Science 237 4818: 992–8 doi:101126/science3303336 PMID 3303336 
    • Arcone R, Arpaia G, Ruoppolo M, et al 1993 "Structural characterization of a biologically active human lipocortin 1 expressed in Escherichia coli" Eur J Biochem 211 1–2: 347–55 doi:101111/j1432-10331993tb19904x PMID 8425544 
    • Weng X, Luecke H, Song IS, et al 1993 "Crystal structure of human annexin I at 25 A resolution" Protein Sci 2 3: 448–58 doi:101002/pro5560020317 PMC 2142391  PMID 8453382 
    • Mailliard WS, Haigler HT, Schlaepfer DD 1996 "Calcium-dependent binding of S100C to the N-terminal domain of annexin I" J Biol Chem 271 2: 719–25 doi:101074/jbc2712719 PMID 8557678 
    • Morgan RO, Fernández MP 1996 "A BC200-derived element and Z-DNA as structural markers in annexin I genes: relevance to Alu evolution and annexin tetrad formation" J Mol Evol 41 6: 979–85 doi:101007/bf00173179 PMID 8587144 
    • Almawi WY, Saouda MS, Stevens AC, et al 1997 "Partial mediation of glucocorticoid antiproliferative effects by lipocortins" J Immunol 157 12: 5231–9 PMID 8955167 
    • Croxtall JD, Wu HL, Yang HY, et al 1998 "Lipocortin 1 co-associates with cytokeratins 8 and 18 in A549 cells via the N-terminal domain" Biochim Biophys Acta 1401 1: 39–51 doi:101016/S0167-48899700120-1 PMID 9459484 
    • Gao J, Li Y, Yan H 1999 "NMR solution structure of domain 1 of human annexin I shows an autonomous folding unit" J Biol Chem 274 5: 2971–7 doi:101074/jbc27452971 PMID 9915835 
    • Manda R, Kohno T, Matsuno Y, et al 1999 "Identification of genes SPON2 and C20orf2 differentially expressed between cancerous and noncancerous lung cells by mRNA differential display" Genomics 61 1: 5–14 doi:101006/geno19995939 PMID 10512675 

    External links

    • Annexin A1 at the US National Library of Medicine Medical Subject Headings MeSH
    • Human ANXA1 genome location and ANXA1 gene details page in the UCSC Genome Browser

    This article incorporates text from the United States National Library of Medicine, which is in the public domain

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    Annexin A1

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