Mon . Mon Jul 2018

Androstadienol


Androstadienol, or androsta-5,16-dien-3β-ol, is an endogenous steroid, pheromone, and chemical intermediate to several other pheromones that is found in the sweat of both men and women

Androstadienol and androstadienone are odorless compounds secreted by the apocrine glands, and via conversion into the more powerfully-odorous androstenone and androstenol catalyzed by aerobic corynebacteria, particularly Corynebacterium xerosis, in men, and Micrococcaceae spp in women, are considered to be mainly responsible for the "musky" component of axillary underarm odor Androstadienol is synthesized from pregnenolone by the 16-ene-synthetase activity of CYP17A1, and is converted into androstadienone by 3β-hydroxysteroid dehydrogenase Male sweat contains approximately five times as much androstenone as does female sweat, which can be explained by sex differences in androstadienol and androstadienone production

Androstadienone, which is produced from androstadienol, has been found to affect brain activity Specifically, it has been found to activate the hypothalamus, most maximally the medial preoptic and anterior hypothalamic areas, in heterosexual women and homosexual men, but not in heterosexual men who instead experienced hypothalamic activation in response to smelling estratetraenol, an estrogen-related pheromone, while heterosexual women and homosexual men did not It has also been found to activate the anterior area of the inferior lateral prefrontal cortex, the superior temporal cortex, and olfactory areas The affected brain areas are thought to be involved in sexual behavior, attention, visual perception/recognition, and social cognition

See also

  • List of neurosteroids § Pheromones and pherines

References

  1. ^ a b c J Stephan Jellinek 6 December 2012 The Psychological Basis of Perfumery Springer Science & Business Media pp 179– ISBN 978-94-009-1567-1 
  2. ^ a b c Fatik Baran Mandal 17 January 2012 Textbook of Animal Behaviour PHI Learning Pvt Ltd pp 296– ISBN 978-81-203-4519-5 
  3. ^ Michael Wilson 2005 Microbial Inhabitants of Humans: Their Ecology and Role in Health and Disease Cambridge University Press pp 104– ISBN 978-0-521-84158-0 
  4. ^ Kaminski, R M 2006 "The Pheromone Androstenol 5 -Androst-16-en-3 -ol Is a Neurosteroid Positive Modulator of GABAA Receptors" Journal of Pharmacology and Experimental Therapeutics 317 2: 694–703 doi:101124/jpet105098319 ISSN 0022-3565 PMID 16415088 
  5. ^ Joseph Johannes; Agnes Maria Weusten 1989 Biochemical pathways in human testicular steroidogenesis PDF Pressa Trajectina 
  6. ^ a b c d Christopher H Hawkes; Richard L Doty 12 February 2009 The Neurology of Olfaction Cambridge University Press pp 37– ISBN 978-0-521-68216-9 





Androstadienol Information about


Androstadienol
Androstadienol
Androstadienol viewing the topic.
Androstadienol what, Androstadienol who, Androstadienol explanation

There are excerpts from wikipedia on this article and video

Random Posts

2007 BCS National Championship Game

2007 BCS National Championship Game

The 2007 Tostitos BCS National Championship Game was an American football game played at the Univers...
Christ Church Meadow, Oxford

Christ Church Meadow, Oxford

Christ Church Meadow is a well-known flood-meadow, and popular walking and picnic spot in Oxford, En...
Politico

Politico

Politico is an American political-journalism organization based in Arlington County, Virginia, that ...
Wayne State University

Wayne State University

Wayne State University WSU is an American public research university located in the Midtown Cultural...