Amphenicols are a class of antibiotics with a phenylpropanoid structure They function by blocking the enzyme peptidyl transferase on the 50S ribosome subunit of bacteria
Examples of amphenicols include chloramphenicol, thiamphenicol, azidamfenicol and florfenicol The first-in-class compound was chloramphenicol, introduced in 1949 Chloramphenicol was initially discovered as a natural product, but all amphenicols are now made by chemical synthesis
- ^ APVMA: Florfenicol
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