Alpha 1-antichymotrypsinalpha 1 antichymotrypsin, elevated fecal alpha 1 antichymotrypsin
1AS4, 1QMN, 2ACH, 3CAA, 3DLW, 4CAA
|Gene location Human|
|Chr||Chromosome 14 human|
|Gene location Mouse|
|Chr||Chromosome 12 mouse|
|Band||12 E|12 5399 cM||Start||104,338,486 bp|
|RNA expression pattern|
|More reference expression data|
|Molecular function|| peptidase inhibitor activity|
serine-type endopeptidase inhibitor activity
|Cellular component|| blood microparticle|
platelet alpha granule lumen
secretory granule lumen
azurophil granule lumen
|Biological process|| regulation of lipid metabolic process|
negative regulation of peptidase activity
maintenance of gastrointestinal epithelium
negative regulation of endopeptidase activity
|Sources:Amigo / QuickGO|
Alpha 1-antichymotrypsin inhibits the activity of certain enzymes called proteases, such as cathepsin G that is found in neutrophils, and chymases found in mast cells, by cleaving them into a different shape or conformation This activity protects some tissues, such as the lower respiratory tract, from damage caused by proteolytic enzymes
This protein is produced in the liver, and is an acute phase protein that is induced during inflammation
Deficiency of this protein has been associated with liver disease Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease
Alpha 1-antichymotrypsin is also associated with the pathogenesis of Alzheimer's disease as it enhances the formation of amyloid-fibrils in this disease
Alpha 1-antichymotrypsin has been shown to interact with DNAJC1
alpha 1 antichymotrypsin, alpha 1 antichymotrypsin elevated, alpha 1 antichymotrypsin stool, elevated fecal alpha 1 antichymotrypsin
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