Sat . Sat Jul 2018

Adrenal ferredoxin


3N9Y, 3N9Z, 3NA0, 3NA1, 3P1M

Identifiers Aliases FDX1, ADX, FDX, LOH11CR1D, Adrenal ferredoxin, ferredoxin 1 External IDs MGI: 103224 HomoloGene: 31216 GeneCards: FDX1
Gene location Human
Chr Chromosome 11 human
Band 11q223 Start 110,429,883 bp
End 110,464,881 bp
RNA expression pattern


More reference expression data
Orthologs Species Human Mouse Entrez
Ensembl
UniProt
RefSeq mRNA

NM_004109

NM_001301728
NM_007996

RefSeq protein

NP_004100

NP_001288657
NP_032022

Location UCSC Chr 11: 11043 – 11046 Mb Chr 9: 5194 – 5196 Mb PubMed search Wikidata
^ "Mouse PubMed Reference:" 
  • ^ Mittal S, Zhu YZ, Vickery LE Sep 1988 "Molecular cloning and sequence analysis of human placental ferredoxin" Arch Biochem Biophys 264 2: 383–91 doi:101016/0003-98618890303-7 PMID 2969697 
  • ^ a b "Entrez Gene: FDX1 ferredoxin 1" 
  • Further reading

    • Grinberg AV, Hannemann F, Schiffler B, et al 2000 "Adrenodoxin: structure, stability, and electron transfer properties" Proteins 40 4: 590–612 doi:101002/1097-01342000090140:4<590::AID-PROT50>30CO;2-P PMID 10899784 
    • Wada A, Waterman MR 1992 "Identification by site-directed mutagenesis of two lysine residues in cholesterol side chain cleavage cytochrome P450 that are essential for adrenodoxin binding" J Biol Chem 267 32: 22877–82 PMID 1429635 
    • Sparkes RS, Klisak I, Miller WL 1991 "Regional mapping of genes encoding human steroidogenic enzymes: P450scc to 15q23-q24, adrenodoxin to 11q22; adrenodoxin reductase to 17q24-q25; and P450c17 to 10q24-q25" DNA Cell Biol 10 5: 359–65 doi:101089/dna199110359 PMID 1863359 
    • Skjeldal L, Markley JL, Coghlan VM, Vickery LE 1991 "1H NMR spectra of vertebrate ferredoxins Hyperfine resonances suggest different electron delocalization patterns from plant ferredoxins" Biochemistry 30 37: 9078–83 doi:101021/bi00101a024 PMID 1909889 
    • Coghlan VM, Vickery LE 1991 "Site-specific mutations in human ferredoxin that affect binding to ferredoxin reductase and cytochrome P450scc" J Biol Chem 266 28: 18606–12 PMID 1917982 
    • Chang CY, Wu DA, Mohandas TK, Chung BC 1990 "Structure, sequence, chromosomal location, and evolution of the human ferredoxin gene family" DNA Cell Biol 9 3: 205–12 doi:101089/dna19909205 PMID 2340092 
    • Chang CY, Wu DA, Lai CC, et al 1989 "Cloning and structure of the human adrenodoxin gene" DNA 7 9: 609–15 doi:101089/dna19887609 PMID 3229285 
    • Voutilainen R, Picado-Leonard J, DiBlasio AM, Miller WL 1988 "Hormonal and developmental regulation of adrenodoxin messenger ribonucleic acid in steroidogenic tissues" J Clin Endocrinol Metab 66 2: 383–8 doi:101210/jcem-66-2-383 PMID 3339111 
    • Picado-Leonard J, Voutilainen R, Kao LC, et al 1988 "Human adrenodoxin: cloning of three cDNAs and cycloheximide enhancement in JEG-3 cells" J Biol Chem 263 7: 3240–4 PMID 3343244 
    • Martsev SP, Chashchin VL, Akhrem AA 1985 "" Biokhimiia 50 2: 243–57 PMID 3872685 
    • Geren LM, Millett F 1981 "Fluorescence energy transfer studies of the interaction between adrenodoxin and cytochrome c" J Biol Chem 256 20: 10485–9 PMID 6270113 
    • Pikuleva IA, Cao C, Waterman MR 1999 "An additional electrostatic interaction between adrenodoxin and P450c27 CYP27A1 results in tighter binding than between adrenodoxin and p450scc CYP11A1" J Biol Chem 274 4: 2045–52 doi:101074/jbc27442045 PMID 9890963 
    • Kostic M, Pochapsky SS, Obenauer J, et al 2002 "Comparison of functional domains in vertebrate-type ferredoxins" Biochemistry 41 19: 5978–89 doi:101021/bi0200256 PMID 11993992 
    • Strausberg RL, Feingold EA, Grouse LH, et al 2003 "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" Proc Natl Acad Sci USA 99 26: 16899–903 doi:101073/pnas242603899 PMC 139241  PMID 12477932 
    • Johnson D, Norman S, Tuckey RC, Martin LL 2004 "Electrochemical behaviour of human adrenodoxin on a pyrolytic graphite electrode" Bioelectrochemistry Amsterdam, Netherlands 59 1–2: 41–7 doi:101016/s1567-53940200188-3 PMID 12699818 
    • Araya Z, Hosseinpour F, Bodin K, Wikvall K 2003 "Metabolism of 25-hydroxyvitamin D3 by microsomal and mitochondrial vitamin D3 25-hydroxylases CYP2D25 and CYP27A1: a novel reaction by CYP27A1" Biochim Biophys Acta 1632 1–3: 40–7 doi:101016/S1388-19810300062-3 PMID 12782149 
    • Gerhard DS, Wagner L, Feingold EA, et al 2004 "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection MGC" Genome Res 14 10B: 2121–7 doi:101101/gr2596504 PMC 528928  PMID 15489334 
    • Derouet-Hümbert E, Roemer K, Bureik M 2005 "Adrenodoxin Adx and CYP11A1 P450scc induce apoptosis by the generation of reactive oxygen species in mitochondria" Biol Chem 386 5: 453–61 doi:101515/BC2005054 PMID 15927889 

    External links

    • Human FDX1 genome location and FDX1 gene details page in the UCSC Genome Browser




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