Thu . Thu Jul 2018


5β-Dihydrotestosterone 5β-DHT, also known as 5β-androstan-17β-ol-3-one or as etiocholan-17β-ol-3-one, is an etiocholane 5β-androstane steroid as well as an inactive metabolite of testosterone formed by 5β-reductase in the liver and bone marrow and an intermediate in the formation of 3α,5β-androstanediol and 3β,5β-androstanediol by 3α- and 3β-hydroxysteroid dehydrogenase and, from them, respectively, etiocholanolone and epietiocholanolone by 17β-hydroxysteroid dehydrogenase Unlike its isomer 5α-dihydrotestosterone 5α-DHT or simply DHT, 5β-DHT either does not bind to or binds only very weakly to the androgen receptor 5β-DHT is notable among metabolites of testosterone in that, due to the fusion of the A and B rings in the cis orientation, it has an extremely angular molecular shape, and this could be related to its lack of androgenic activity 5β-DHT, unlike 5α-DHT, is also inactive in terms of neurosteroid activity, although its metabolite, etiocholanolone, does possess such activity

See also

  • 3α-Androstanediol
  • 3β-Androstanediol
  • Androsterone
  • Epiandrosterone


  1. ^ a b Hormones, Brain and Behavior Online Academic Press 18 June 2002 pp 2262– ISBN 978-0-08-088783-8 
  2. ^ H-J Bandmann; R Breit; E Perwein 6 December 2012 Klinefelter’s Syndrome Springer Science & Business Media pp 293– ISBN 978-3-642-69644-2 
  3. ^ Shlomo Melmed; Kenneth S Polonsky; P Reed Larsen; Henry M Kronenberg 30 November 2015 Williams Textbook of Endocrinology Elsevier Health Sciences pp 711– ISBN 978-0-323-29738-7 
  4. ^ Anita H Payne; Matthew P Hardy 28 October 2007 The Leydig Cell in Health and Disease Springer Science & Business Media pp 186– ISBN 978-1-59745-453-7 
  5. ^ BA Cooke; HJ Van Der Molen; RJB King 1 November 1988 Hormones and their Actions Elsevier pp 173– ISBN 978-0-08-086077-0 
  6. ^ Current Topics in Membranes and Transport Academic Press 1 February 1988 pp 169– ISBN 978-0-08-058502-4 
  7. ^ Abraham Weizman 1 February 2008 Neuroactive Steroids in Brain Function, Behavior and Neuropsychiatric Disorders: Novel Strategies for Research and Treatment Springer Science & Business Media pp 210– ISBN 978-1-4020-6854-6 
  8. ^ Li P, Bracamontes J, Katona BW, Covey DF, Steinbach JH, Akk G June 2007 "Natural and enantiomeric etiocholanolone interact with distinct sites on the rat alpha1beta2gamma2L GABAA receptor" Mol Pharmacol 71 6: 1582–90 doi:101124/mol106033407 PMID 17341652 
  9. ^ Kaminski RM, Marini H, Kim WJ, Rogawski MA June 2005 "Anticonvulsant activity of androsterone and etiocholanolone" Epilepsia 46 6: 819–27 doi:101111/j1528-1167200500705x PMC 1181535  PMID 15946323 

5β-Dihydrotestosterone Information about

5β-Dihydrotestosterone viewing the topic.
5β-Dihydrotestosterone what, 5β-Dihydrotestosterone who, 5β-Dihydrotestosterone explanation

There are excerpts from wikipedia on this article and video

Random Posts

Outline of Northern Ireland

Outline of Northern Ireland

The following outline is provided as an overview of and topical guide to Northern Ireland Northern I...
Manner (confectionery)

Manner (confectionery)

Manner German pronunciation: ˈmanɐ  listen is a line of confectionery from the Austrian conglom...


Frederiksværk is a town with a population of 12,076 1 January 2015 in Halsnæs Municipality on Zealan...
Kalleby Runestone

Kalleby Runestone

The Kalleby Runestone is an enigmatic Iron Age runestone inscribed in Proto-Norse with the Elder Fut...