5β-Dihydrotestosterone 5β-DHT, also known as 5β-androstan-17β-ol-3-one or as etiocholan-17β-ol-3-one, is an etiocholane 5β-androstane steroid as well as an inactive metabolite of testosterone formed by 5β-reductase in the liver and bone marrow and an intermediate in the formation of 3α,5β-androstanediol and 3β,5β-androstanediol by 3α- and 3β-hydroxysteroid dehydrogenase and, from them, respectively, etiocholanolone and epietiocholanolone by 17β-hydroxysteroid dehydrogenase Unlike its isomer 5α-dihydrotestosterone 5α-DHT or simply DHT, 5β-DHT either does not bind to or binds only very weakly to the androgen receptor 5β-DHT is notable among metabolites of testosterone in that, due to the fusion of the A and B rings in the cis orientation, it has an extremely angular molecular shape, and this could be related to its lack of androgenic activity 5β-DHT, unlike 5α-DHT, is also inactive in terms of neurosteroid activity, although its metabolite, etiocholanolone, does possess such activity
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