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21-Deoxycortisone


21-Deoxycortisone, also known as 21-desoxycortisone, 11-keto-17α-hydroxyprogesterone, or 17α-hydroxypregn-4-ene-3,11,20-trione, is a naturally occurring, endogenous steroid and minor intermediate and metabolite in corticosteroid metabolism It is related to 21-deoxycortisol 11β,17α-dihydroxyprogesterone and is reversibly formed from it by 11β-hydroxysteroid dehydrogenase, analogously to the reversible formation of cortisone from cortisol 21-Deoxycortisone can be transformed into cortisone by 21-hydroxylase

See also

  • 11-Dehydrocorticosterone
  • 11-Ketoprogesterone
  • 17α-Hydroxyprogesterone

References

  1. ^ Homma K, Hasegawa T, Takeshita E, Watanabe K, Anzo M, Toyoura T, Jinno K, Ohashi T, Hamajima T, Takahashi Y, Takahashi T, Matsuo N 2004 "Elevated urine pregnanetriolone definitively establishes the diagnosis of classical 21-hydroxylase deficiency in term and preterm neonates" J Clin Endocrinol Metab 89 12: 6087–91 doi:101210/jc2004-0473 PMID 15579762 
  2. ^ ROSENFELD G, UNGAR F, DORFMAN RI, PINCUS G 1955 "Irradiation and adrenal steroidogenesis: steroid transformations by irradiated isolated perfused calf adrenals" Endocrinology 56 1: 24–9 doi:101210/endo-56-1-24 PMID 13220521 





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