Sun . 19 May 2019

20α,22R-Dihydroxycholesterol


20α,22R-Dihydroxycholesterol, or 3β-cholest-5-ene-3,20,22-triol is an endogenous, metabolic intermediate in the biosynthesis of the steroid hormones from cholesterol Cholesterol 3β-cholest-5-en-3-ol is hydroxylated by cholesterol side-chain cleavage enzyme P450scc to form 22R-hydroxycholesterol, which is subsequently hydroxlated again by P450scc to form 20α,22R-dihydroxycholesterol, and finally the bond between carbons 20 and 22 is cleaved by P450scc to form pregnenolone 3β-3-hydroxypregn-5-en-20-one, the precursor to the steroid hormones

See also

  • 22R-Hydroxycholesterol
  • 27-Hydroxycholesterol

References

  1. ^ a b CHAUDHURI AC, HARADA Y, SHIMIZU K, GUT M, DORFMAN RI March 1962 "Biosynthesis of pregnenolone from 22-hydroxycholesterol" The Journal of Biological Chemistry 237: 703–4 PMID 13878470 
  2. ^ a b Hume R, Kelly RW, Taylor PL, Boyd GS May 1984 "The catalytic cycle of cytochrome P-450scc and intermediates in the conversion of cholesterol to pregnenolone" European Journal of Biochemistry / FEBS 140 3: 583–91 doi:101111/j1432-10331984tb08142x PMID 6723652 



20α,22R-Dihydroxycholesterol Information about

20α,22R-Dihydroxycholesterol


  • user icon

    20α,22R-Dihydroxycholesterol beatiful post thanks!

    29.10.2014


20α,22R-Dihydroxycholesterol
20α,22R-Dihydroxycholesterol
20α,22R-Dihydroxycholesterol viewing the topic.
20α,22R-Dihydroxycholesterol what, 20α,22R-Dihydroxycholesterol who, 20α,22R-Dihydroxycholesterol explanation

There are excerpts from wikipedia on this article and video

Random Posts

La Porte, Indiana

La Porte, Indiana

La Porte French for "The Door" is a city in LaPorte County, Indiana, United States, of which it is t...
Fernando Montes de Oca Fencing Hall

Fernando Montes de Oca Fencing Hall

The Fernando Montes de Oca Fencing Hall is an indoor sports venue located in the Magdalena Mixhuca S...
My Everything (The Grace song)

My Everything (The Grace song)

"My Everything" was Grace's 3rd single under the SM Entertainment, released on November 6, 2006 Unli...
Turkish Straits

Turkish Straits

The Turkish Straits Turkish: Türk Boğazları are a series of internationally significant waterways in...