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16α-Hydroxyandrostenedione


16α-Hydroxyandrostenedione 16α-OH-A4, also known as 16α-hydroxyandrost-4-ene-3,17-dione, is an endogenous and naturally occurring steroid and metabolic intermediate in the biosynthesis of estriol during pregnancy It is produced from dehydroepiandrosterone DHEA, which is converted into 16α-hydroxy-DHEA sulfate, then desulfated and aromatized into 16α-hydroxyestrone, and finally converted into estriol by 17β-hydroxysteroid dehydrogenase

See also

  • 15α-Hydroxydehydroepiandrosterone
  • Androstenedione
  • 11β-Hydroxyandrostenedione

References

  1. ^ a b Rodney Rhoades; David R Bell 2009 Medical Physiology: Principles for Clinical Medicine Lippincott Williams & Wilkins pp 713–714 ISBN 978-0-7817-6852-8 
  2. ^ a b Charles Graham 2 December 2012 Reproductive Biology of the Great Apes: Comparative and Biomedical Perspectives Elsevier pp 56– ISBN 978-0-323-14971-6 
  3. ^ Vitamins and Hormones Academic Press 7 September 2005 pp 282– ISBN 978-0-08-045978-3 




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16α-Hydroxyandrostenedione


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