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11β-Hydroxyprogesterone


11β-Hydroxyprogesterone 11β-OHP, also known as 21-deoxycorticosterone, as well as 11β-hydroxypregn-4-ene-3,20-dione, is a naturally occurring, endogenous steroid and derivative of progesterone It is a potent mineralocorticoid Increased levels of 11β-OHP occur in 21-hydroxylase deficiency

Along with its epimer 11α-hydroxyprogesterone 11α-OHP, 11β-OHP has been identified as a very potent competitive inhibitor of both isoforms 1 and 2 of 11β-hydroxysteroid dehydrogenase 11β-HSD

See also

  • 21-Deoxycortisol 11β,17α-dihydroxyprogesterone
  • 11-Deoxycorticosterone 21-hydroxyprogesterone
  • Corticosterone 11β,21-dihydroxyprogesterone
  • Cortisol 11β,17α,21-trihydroxyprogesterone
  • 11-Deoxycortisol 17α,21-dihydroxyprogesterone
  • 9α-Bromo-11-ketoprogesterone

References

  1. ^ a b c "Human Metabolome Database: Showing metabocard for 11b-Hydroxyprogesterone HMDB04031" hmdbca Retrieved 2016-12-16 
  2. ^ Souness GW, Latif SA, Laurenzo JL, Morris DJ 1995 "11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of 11 beta-hydroxysteroid dehydrogenase isoforms 1 and 2, confer marked mineralocorticoid activity on corticosterone in the ADX rat" Endocrinology 136 4: 1809–12 doi:101210/endo13647895695 PMID 7895695 
  3. ^ Souness GW, Morris DJ 1996 "11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of 11 beta-hydroxysteroid dehydrogenase, possess hypertensinogenic activity in the rat" Hypertension 27 3 Pt 1: 421–5 PMID 8698448 

External links

  • Metabocard for 11β-Hydroxyprogesterone HMDB04031 - Human Metabolome Database




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